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| 1 | 血液ALT和AST活性降低的毒理学意义显示文摘血液ALT(丙氨酸转氨酶)和AST(天门冬氨酸转氨酶)活性的测定,在毒理学实验中具有重要意义。损伤的肝细胞释放入血液的转氨酶测定已成为评价肝中毒最有用的工具。转氨酶活性增高的临床意义是众所周知的,而ALT和AST活性降低的意义却知之甚少。本文综述了已知与这两种酶活性降低的有关研究及其变化的生物学意义。 | Waner T. 宋晓平 | 1992 | 国外兽医学(畜禽疾病)1992，13，1： | 7 |
| 2 | Surveying brain tumor heterogeneity by single-cell RNA-sequencing of multi-sector biopsies显示文摘Brain tumors are among the most challenging human tumors for which the mechanisms driving progression and heterogeneity remain poorly understood.We combined single-cell RNA-seq with multi-sector biopsies to sample and analyze single-cell expression profiles of gliomas from 13 Chinese patients.After classifying individual cells;we generated a spatial and temporal landscape of glioma that revealed the patterns of invasion between the different sub-regions of gliomas.We also used single-cell inferred copy number variations and pseudotime trajectories to inform on the crucial branches that dominate tumor progression.The dynamic cell components of the multi-region biopsy analysis allowed us to spatially deconvolute with unprecedented accuracy the transcriptomic features of the core and those of the periphery of glioma at single-cell level.Through this rich and geographically detailed dataset,we were also able to characterize and construct the chemokine and chemokine receptor interactions that exist among different tumor and non-tumor cells.This study provides the first spatial-level analysis of the cellular states that characterize human gliomas.It also presents an initial molecular map of the cross-talks between glioma cells and the surrounding microenvironment with single-cell resolution. | Kai Yu Yuqiong Hu Fan Wu Qiufang Guo Zenghui Qian Waner Hu Jing Chen Kuanyu Wang Xiaoying Fan Xinglong Wu John EJ Rasko Xiaolong Fan Antonio lavarone Tao Jiang Fuchou Tang Xiao-Dong Su | 2020 | National Science Review2020，7，8： | 4 |
| 3 | Antagonism between coral pathogen Vibrio coralliilyticus and other bacteria in the gastric cavity of scleractinian coral Galaxea fascicularis显示文摘Scleractinian corals host numerous microbial symbionts with different types of interactions. The gastric cavity of scleractinian coral, as a semiclosed subenvironment with distinct chemical characteristics(e.g., dissolved O2, pH, alkalinity, and nutrients), harbors a distinct microbial community and a diverse array of bacteria that can be pathogenic or beneficial. Galaxea fascicularis is one of the dominant massive scleractinian coral species on inshore fringing reefs in the northern South China Sea.Although the abundance of coral-associated bacteria has been investigated in G. fascicularis, less is known about the microorganisms in the gastric cavity. In this study, we specially isolated cultivable bacterial strains from the gastric cavity of G.fascicularis collected from Hainan Island using a noninvasive sampling approach. Among the 101 representative bacterial strains, one Vibrio coralliilyticus strain, SCSIO 43001, was found to be a temperature-dependent opportunistic pathogen of G.fascicularis. The antagonistic activity between the 100 strains and V. coralliilyticus SCSIO 43001 was tested using a modified Burkholder diffusion assay. Our results showed that V. coralliilyticus SCSIO 43001 inhibits the growth of Erythrobacter flavus and Sphingomonas yabuuchiae. Additionally, we found that three Pseudoalteromonas strains showed moderate to high antibacterial activity against V. coralliilyticus SCSIO 43001 and several other coral-associated Gram-negative bacterial strains.These results suggest that competition between the coral pathogen and other bacteria also occurs in the gastric cavity of coral, and Pseudoalteromonas strains in the gastric cavity of G. fascicularis may provide a protective role in the defense against coinhabiting coral pathogens at elevated temperature. | Kaihao TANG Waner ZHAN Yiqing ZHOU Tao XU Xiaoqing CHEN Weiquan WANG Zhenshun ZENG Yan WANG Xiaoxue WANG | 2020 | Science China Earth Sciences2020，63，1： | 2 |
| 4 | Management of congenital vascular lesions of the head and neck显示文摘 | Waner M Suen JY | 1995 | Oncology( Williston Park )1995，9，8： | 1 |
| 5 | GLUT1 : a newly discov- ered immunohistochemical marker for juvenile hemangiomas 显示文摘 | North PE Waner M Mizeracki A | 2000 | Hum Pathol2000，31，1： | 1 |
| 6 | Vascular tumors of infancy and child-hood: beyond capillary hemangioma显示文摘 | North P E Waner M Buckmiller L | 2006 | Cardiovasc Pathol2006，15，6： | 1 |
| 7 | Immunoperoxidase study of the endolymphatic sac in Meniere' s disease显示文摘 | DORNHOFFER J L WANER M ARENBRG I K | 1993 | Laryngoscope1993，103，9： | 1 |
| 8 | Vascular tumors of infancy and childhood: beyond capillary hemangioma 显示文摘 | North PE Waner M Buckmiller L | 2006 | Cardiovasc Pathol2006，15，6： | 1 |
| 9 | Hemangiomas of the nose: surgical management using a modified subunit approach显示文摘 | Waner M Kastenbaum J Scherer K | 2008 | Arch Facial Plast Surg2008，10，5： | 1 |
| 10 | somatic mutations of vascular endothelial growth factor receptors in juvenile hemangioma显示文摘 | Walter Jw North PE Waner M | | 0，，03： | 1 |
| 11 | A unique microvascular phenotype shared by juvenile hemangiomas and human placenta显示文摘 | NORTH P E WANER M MIZERACKI A | 2001 | Arch Dermatol2001，137，5： | 1 |
| 12 | Exercise therapy across the lung cancer continuum显示文摘 | Jones LW Eves ND Waner E | 2009 | Curr Oncol Rep2009，11，4： | 1 |
| 13 | GLUT1:a newly discovered immunohistochemical marker for juvenile hemangiomas显示文摘 | North PE Waner M Mizeracki A | 2000 | Hum Pathol2000，31，1： | 1 |
| 14 | Somatic mutation of vascular endothelial growth factor receptors in juvenile he- mangioma显示文摘 | Walter J W North P E Waner M | 2002 | Genes Chromosomes Cancer2002，33，3： | 1 |
| 15 | Enantiomeric separation use of calixarene EKC显示文摘 | Pena M S Zhang Y L Waner I M | 1997 | Anal Chem1997，，69： | 1 |
| 16 | Stability of peakons显示文摘 | Adrian Constantin Waner A Atrauss | | 0，，： | 1 |
| 17 | Vascular anomalies of the head and neck:a review of genetics显示文摘 | Yadav P De Castro D K Waner M | 2013 | Semin Ophthal- mol2013，28，56： | 1 |
| 18 | Effect of cadmium on bone repair in young rats 显示文摘 | Gur E Waner T Barushka-Eizik O | 1995 | Toxicol Enviro Health1995，45，3： | 1 |
| 19 | Glutl: a newly discovered immunohistochemical marker for juvenile hemangiomas显示文摘 | North PE Waner M Mizeracki A | 2000 | Hum Pathol2000，31，1： | 1 |
| 20 | Congenital nonprogressive hemang ioma:a distinct clinicopathoiogic entity unlike infantile hemangioma显示文摘 | North PE Waner M James CA | 2001 | Arch Dermatol2001，137，： | 1 |
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