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| 1 | Vitamin D deficiency: Correlation to interleukin-17, interleukin-23 and PⅢNP in hepatitis C virus genotype 4显示文摘AIM: To assess vitamin D (Vit D) abnormalities in hepatitis C infected patients and their relationship with interleukin (IL)-17, IL-23 and N-terminal propeptide of type Ⅲ pro-collagen (PⅢNP) as immune response mediators. METHODS: The study was conducted on 50 Egyptian patients (36 male, 14 female) with hepatitis C virus (HCV) infection, who visited the Hepatology Outpatient Clinic in the Endemic Disease Hospital at Cairo University. Patients were compared with 25 ageand sexmatched healthy individuals. Inclusion criteria were based on a history of liver disease with HCV genotype 4 (HCV-4) infection (as new patients or under followup). Based on ultrasonography, patients were classified into four subgroups; 14 with bright hepatomegaly; 11 with perihepatic fibrosis; 11 with hepatic cirrhosis; and 14 with cirrhosis and hepatocellular carcinoma (HCC).Total Vit D (i.e., 25-OH-Vit D) and active Vit D [i.e., 1,25-(OH) 2 -Vit D] assays were carried out using commercial kits. IL-17, IL-23 and PⅢNP levels were assayed using enzyme linked immunosorbent assay kits, while HCV virus was measured by quantitative and qualitative polymerase chain reaction. RESULTS: Levels of Vit D and its active form were significantly lower in advanced liver disease (hepatic cirrhosis and/or carcinoma) patients, compared to those with bright hepatomegaly and perihepatic fibrosis. IL-17, IL-23 and PⅢNP levels were markedly increased in HCV patients and correlated with the progression of hepatic damage. The decrease in Vit D and active Vit D was concomitant with an increase in viral load, as well as levels of IL-17, IL-23 and PⅢNP among all subgroups of HCV-infected patients, compared to normal healthy controls. A significant negative correlation was evident between active Vit D and each of IL-17, IL-23 and PⅢNP (r = -0.679, -0.801 and -0.920 at P < 0.001, respectively). HCV-infected men and women showed no differences with respect to Vit D levels. The viral load was negatively correlated with Vit D and active Vit D (r = -0.084 and -0.846 at P < 0.001, respectively), and positively correlated with IL-17, IL-23 and PⅢNP (r = 0.951, 0.922 and 0.94 at P < 0.001, respectively). Whether the deficiency in Vit D was related to HCVinduced chronic liver disease or was a predisposing factor for a higher viral load remains to be elucidated. CONCLUSION: The negative correlations between Vit D and IL-17, IL-23 and PⅢNP highlight their involvement in the immune response in patients with HCV-4related liver diseases in Egypt. | Mona F Schaalan Waleed A Mohamed Hesham H Amin | 2012 | World Journal of Gastroenterology2012，18，28： | 12 |
| 2 | Mechanisms of fibrinolysis resistance and potential targets for thrombolysis in acute ischaemic stroke: lessons from retrieved stroke emboli显示文摘There has been growing interest and insight into the histological composition of retrieved stroke emboli.One of the main focuses of the stroke clot analysis literature has been the implications of clot composition on mechanical thrombectomy procedures.However,the holy grail of clot analysis may not be in the field of clot-device interaction,but rather,in understanding mechanisms of fibrinolysis resistance.The mechanisms underlying the low response to fibrinolytic therapy,even with the newer,more powerful agents,remain poorly understood.While factors such as embolus size,location and collateral status influence alteplase delivery and recanalisation rates;compositional analyses focused on histological and ultrastructural characteristics offer unique insights into mechanisms of alteplase resistance.In this review,we strive to provide comprehensive review of current knowledge on clot composition and ultrastructural analyses that help explain resistance to fibrinolysis. | Waleed Brinjikji Oana Madalina Mereuta Daying Dai David F Kallmes Luis Savastano Yang Liu Shahid M Nimjee Raul G Nogueira Mehdi Abbasi Ramanathan Kadirvel | 2021 | Stroke & Vascular Neurology2021，6，4： | 2 |
| 3 | Microsurgical reconstruction of the oral cavity with free flaps from the anterolateral thigh and theradial forearm:a comparison of perioperative data from 161 cases显示文摘 | Kesting MR H(o)lzle F Wales C | 2011 | Ann Surg Oneol2011，18，7： | 1 |
| 4 | Global search method for locating general slip surface using Monte Carlo techniques显示文摘 | Abdallah I Husein Malkawi Waleed F Hassan Sarada K Sarma | 2001 | Journal of Geotechnical and Geoenvironmental Engineering ASCE2001，127，8： | 1 |
| 5 | Global Search method for locating general slip surface using Monte Carlo techniques显示文摘 | Abdallah I Husein Malkawi Waleed F Hassan Sarada K Sama | 2001 | Journal of Geotechnical and Geoenvironmental Engineering ASAE2001，127，8： | 1 |
| 6 | Uncertainty and reliability analysis applied to slope stability显示文摘 | Abdallah I Husein Malkawi Hassan Waleed F Abdulla Fayez A | 2000 | Structural Safety2000，22，2： | 1 |
| 7 | Closure to 'Global Search Method for locating general slip surface using Monte Carlo Techniques'显示文摘 | Abdallah I Husein Malkawi Waleed F | 2002 | Journal of Geotechnical and Geoenviromental Engineering2002，128，10： | 1 |
| 8 | Global search method for locating general slip surface using monte carlo techniques显示文摘 | Abdallah I Husein Malkawi Waleed F Hassan Sarada K Sarma | 2001 | Journal of Geotechnical and Geoenvironmental Engineering2001，127，8： | 1 |
| 9 | An efficient search method for finding the critical circular slip surface using the monte carlo technique显示文摘 | Abdallah I Husein Malkawi Waleed F Hassan Sarada K Sarma | 2001 | Canadian Geotechnical Journal2001，38，： | 1 |
| 10 | Sarma, Global Search method for locating general slip surface using monte carlo techniques显示文摘 | ABDALLAH I HUSEIN Malkawi WALEED F | 2001 | Journal of Geotechnical and Geoenvironmental Engineering2001，127，8： | 1 |
| 11 | Sarma global search method for locating general slip surface using Monte Carlo techniques显示文摘 | Abdallah I Husein Malkawi Waleed F Hassan Sarada K | 2001 | Journal of geotechnical and geoenvironmental engineering2001，127，68： | 1 |
| 12 | Global search method for locating general slip surface using monte carlo techniques 显示文摘 | Abdallah I Husein Malkawi Waleed F Hassan Sarada K Samla | 2001 | Journal of Geotechnical and Geoenvironmental Engineering2001，127，8： | 1 |
| 13 | An efficient search method for finding the critical circular slip surface using the monte carlo technique显示文摘 | Abdallah I Husein Malkawi Waleed F Hassan Sarada K Sarma | 2001 | Canadian Geotechnical Journal2001，38，： | 1 |
| 14 | Microsurgical recon- struction of the oral cavity with free flaps from the anterolat- eral thigh and the radial forearm:a comparison of periopera- tire data from 161 cases 显示文摘 | Kesting MR H~lzle F Wales C | 2011 | Ann Surg Oncol2011，18，： | 1 |
| 15 | The role of corticotropin- releasing faetor receptors in stress and anxiety显示文摘 | Bale T L Lee K F Wale W W | 2002 | Integr Comp Biol2002，42，3： | 1 |
| 16 | Seroprevalence of major blood-borne infections among blood donors at Felege Hiwot referral hospital, northwest Ethiopia显示文摘 | Dessie A Abera B Wale F | 2007 | Ethiop J Health Dev2007，21，1： | 1 |
| 17 | Design of FPGA based PID-like fuzzy controller for industrial ap- plications显示文摘 | MOHAMMED Y HASSAN WALEED F | 2007 | IAENG International Journal of Com- puter Science2007，34，： | 1 |
| 18 | Pathological mecha- nisms implicated in localized female trapezius myalgia显示文摘 | Kadi F Waling K Ahlgren C | 1998 | Pain1998，78，： | 1 |
| 19 | Dynamic characterisati- on of elastomeric engine mounts of different geometry used in automotive industry : simulation approach 显示文摘 | WALEED F Fads FAZIDAH Saad | 2010 | Vehicle Noise and Vibration2010，6，1： | 1 |
| 20 | First principles calculations of solubilities and doping limits: Li, Na, and N in ZnSe显示文摘 | Vande Wale C G Laks D B Neumark G F | 1993 | Phys Rev B1993，47，： | 1 |
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