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10篇 您的检索式：作者名="Waithman"

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		题名	作者	年代	出处	被引量
	1	T cells recognizing a llmer influenza peptide complexed to H-2D(b) show promiscuity for peptide length 显示文摘	Zanker D Quinn K Waithman J	2015	Immunol Cell Biol2015，93，5：	1
	2	Dendritic cell induced memory T cell activation in nonlymphoid tissues显示文摘	Wakim LM Waithman J van Rooijen N	2008	Science2008，319，5860：	1
	3	Dendritic cell-induced memory T cell activation in non-lymphoid tissues显示文摘	Wakim L M Waithman J Rooijen N	2008	Science2008，319，5860：	1
	4	Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL priming显示文摘	Allan RS Waithman J Bedoui S	2006	Immunity2006，25，1：	1
	5	Cognate CD4+T cell licensing of dendritic cells in CD8 +T cell immunity显示文摘	SMITH C M WILSON N S WAITHMAN J	2004	Nat Immuno12004，5，：	1
	6	Cutting edge: enhanced IL-2 signaling can convert self-specific T cell response from Tolerance to Autoimmunity 显示文摘	Waithman J Gebhardt T Davey GM	2008	J Immunol2008，180，9：	1
	7	Influenza A infection enhances cross-priming of CD8+ T cells to cell-associated antigens in a TLR7-and type I IFN-dependent fashion显示文摘	Wei J Waithman J Lata R		0，，10：	1
	8	Cognate CD4(+) T cell licensing of dendritic cells in CD8(+) T cell immunity显示文摘	Smith CM Wilson NS Waithman J	2004	Nat Immunol2004，5，11：	1
	9	Cognate CD4 ( + ) T cell licensing of dendritic ceils in CD8 ( + ) T cell immunity显示文摘	Smith C M Wilson N S Waithman J	2004	Nat Immunol2004，5，：	1
	10	Non-severe burn injury increases cancer incidence in mice and has long-term impacts on the activation and function of T cells显示文摘Background:Recent evidence suggests that burn patients are at increased risk of hospital admission for infection,mental health conditions,cardiovascular disease and cancer for many years after discharge for the burn injury itself.Burn injury has also been shown to induce sustained immune system dysfunction.This change to immune function may contribute to the increased risk of chronic disease observed.However,the mechanisms that disrupt long-term immune function in response to burn trauma,and their link to long-term morbidity,remain unknown.In this study we investigated changes to immune function after burn injury using a murine model of non-severe injury.Methods:An established mouse model of non-severe burn injury(full thickness burn equivalent to 8%total body surface area)was used in combination with an orthotopic model of B16 melanoma to investigate the link between burns and cancer.Considering that CD8^(+)T cells are important drivers of effective tumour suppression in this model,we also investigated potential dysregulation of this immune population using mouse models of burn injury in combination with herpes simplex virus infection.Flow cytometry was used to detect and quantify cell populations of interest and changes in immune function.Results:We demonstrate that 4 weeks after a non-severe burn injury,mice were significantly more susceptible to tumour development than controls using an orthotopic model of B16 melanoma.In addition,our results reveal that CD8^(+)T cell expansion,differentiation and memory potential is significantly impaired at 1 month post-burn.Conclusions:Our data suggests that CD8^(+)T cell-mediated immunity may be dysfunctional for a sustained period after even non-severe burn injury.Further studies in patients to validate these findings may support clinical intervention to restore or protect immunity in patients after burn injury and reduce the increased risk of secondary morbidities observed.	Lucy W.Barrett Vanessa S.Fear Bree Foley Katherine Audsley Samantha Barnes Hannah Newnes Alison McDonnell Fiona M.Wood Mark W.Fear Jason Waithman	2022	Burns & Trauma2022，10，1：	0

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