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| 1 | Role of observation of live cases done by Japanese experts in the acquisition of ESD skills by a western endoscopist显示文摘AIM:To evaluate the role of observation of experts performing endoscopic submucosal dissection(ESD)in the acquisition of ESD skills.METHODS:This prospective study is documenting the learning curve of one Western endoscopist.The study consisted of three periods.In the first period(preobservation),the trainee performed ESDs in animal models in his home institution in the United States.The second period(observation)consisted of visit to Japan and observation of live ESD cases done by experts.The observation of cases occurred over a 5-wk period.During the third period(post-observation),the trainee performed ESD in animal models in a similar fashion as in the first period.Three animal models were used:live40-50 kg Yorkshire pig,explanted pig stomach model,and explanted pig rectum model.The outcomes from the ESDs done in the animal models before and after observation of live human cases(main study intervention)were compared.Statistical analysis of the data included:Fisher’s exact test to compare distributions of a categorical variable,Wilcoxon rank sum test to compare distributions of a continuous variable between the two groups(pre-observation and post-observation),and Kruskal-Wallis test to evaluate the impact of lesion location and type of model(ex-vivo vs live pig)on lesion removal time.RESULTS:The trainee performed 38 ESDs in animal model(29 pre-observation/9 post-observation).The removal times post-observation were significantly shorter than those pre-observation(32.7±15.0 min vs 63.5±9.8 min,P<0.001).To minimize the impact of improving physician skill,the 9 lesions post-observation were compared to the last 9 lesions pre-observation and the removal times remained significantly shorter(32.7±15.0 min vs 61.0±7.4 min,P=0.0011).Regression analysis showed that ESD observation significantly reduced removal time when controlling for the sequence of lesion removal(P=0.025).Furthermore,it was also noted a trend towards decrease in failure to remove lesions and decrease in complications after the period of observation.This study did not find a significant difference in the time needed to remove lesions in different animal models.This finding could have important implications in designing training programs due to the substantial difference in cost between live animal and explanted organ models.The main limitation of this study is that it reflects the experience of a single endoscopist.CONCLUSION:Observation of experts performing ESD over short period of time can significantly contribute to the acquisition of ESD skills. | Peter V Draganov Myron Chang Roxana M Coman Mihir S Wagh Qi An Takuji Gotoda | 2014 | World Journal of Gastroenterology2014，20，16： | 3 |
| 2 | On measuring the Pancharatnam phase显示文摘 | WAGH A G RAKHECHA V C | 1995 | Phys Lett A1995，197，： | 1 |
| 3 | Chemoprotective mechanism of the natural compounds, epigallocatechin-3- O-gallate,quercetin and curcumin against cancer and car- diovascular diseases 显示文摘 | Jagtap S Meganathan K Wagh V | 2009 | Current Medicinal Chemistry2009，16，12： | 1 |
| 4 | Prospective e- valuation of the use of fully covered self-expanding metal stents for EUS-guided transmural drainage of pancreatic pseudocysts显示文摘 | Penn D E Draganov P V Wagh M S | 2012 | Gastrointest Endose2012，76，3： | 1 |
| 5 | Prospective evaluation of the use of fully covered self-expanding metal stents for EUS-guided transmural drainage of pancreatic pseudo- cysts显示文摘 | Penn D E Draganov P V Wagh M S Forsmark C E Gupte A R Chauhan S S | 2012 | Gastrointest Endosc2012，76，： | 1 |
| 6 | Heseheler J and Sachinidis A:Chemoprotective mechanism of the natural compounds,epigallocatechin -3 -o -gallate,quercetin and curcumin against cancer and cardiovascular diseases 显示文摘 | Jagtap S Meganathan K Wagh V | 2009 | Curr Med Chem2009，16，12： | 1 |
| 7 | Identification of thalidomide-specific transcriptomies and proteomics signatures during differentiation of human embryonic stem cells显示文摘 | Meganathan K Jagtap S Wagh V | 2012 | PLoS One2012，7，44： | 1 |
| 8 | Chemoprotective mechanism of the natural compounds, epigallocatechin- 3-0-gallate, quercetin and curcumin against cancer and cardiovascular diseases显示文摘 | JAGTAP S MEGANATHAN K WAGH V | 2009 | Curr Med Chern2009，16，12： | 1 |
| 9 | Gas holdup in a two-phase reversed flow jet loop reactor显示文摘 | S M Wagh K V Koranne R B Mankar | 2010 | The Canadian Journal of Chemical Engineering2010，88，5： | 1 |
| 10 | Experimental and modeling studies on microwave-assisted extraction of thymol from seeds of Trachyspermum ammi (TA)显示文摘 | GUJAR J WAGH S GAIKAR V | 2010 | Separation and Purification Technology2010，70，： | 1 |
| 11 | Development and evalua- tion of tamarind seed xyloglucan - based mucoadhesive buccal films of rizatriptan benzoate 显示文摘 | AVACHAT A M GUJAR K N WAGH K V | 2013 | Carbohydrate Polymers2013，91，2： | 1 |
| 12 | Hirayama's disease: the importance of flexion magnetic resonance imaging显示文摘 | Jakhere S Wagh V | 2011 | J Postgrad Med2011，57，1： | 1 |
| 13 | Tissue expansion: Concepts, techniques and unfavourable results显示文摘 | Wagh MS Dixit V | 2013 | Indian J Plast Surg2013，46，2： | 1 |
| 14 | Comparison of some physicochemical properties of hydrophilic and hydrophobic silica aerogels显示文摘 | Wagh P B Ingale S V | 2002 | Ceramics International2002，28，： | 1 |
| 15 | Diagnostic accuracy of conventional and cholangioscopy-guided sam-piing of indeterminate biliary lesions at the time of ERCP:a prospective,long-term follow-up study 显示文摘 | Draganov P V Chauhan S Wagh M S | 2012 | Gastrointest Endosc2012，75，2： | 1 |
| 16 | Synthesis and micro struc- tural investigations of titania-silica nano composite aerogels 显示文摘 | Ingale S V Sastry P U Wagh P B | 2012 | Materials Chemistry and Physics2012，135，23： | 1 |
| 17 | Comparison of some physieo- chemical properties of hydrophilic and hydrophobic silica aerogets 显示文摘 | Wagh P B lngale S V | 2002 | Ceramics International2002，28，： | 1 |
| 18 | Improving quality of apple using computer vision & image processing based grading system 显示文摘 | Sadegaonkar V D Wagh K H | 2015 | International Journal of Science and Research2015，4，4： | 1 |
| 19 | Automatic sorting u- sing computer vision & image processing for improving apple quality显示文摘 | Sadegaonkar V D Wagh K H | 2015 | International Journal of Innovative Re- search & Development2015，4，1： | 1 |
| 20 | Chemoprotective mechanism of the natural compounds ,epigallocatech in-3- O-gallate, quercetin and curcumin against cancer and car- diovascular diseases 显示文摘 | Jagtap S Meganathan K Wagh V | 2009 | Current Medicinal Chemistry2009，16，12： | 1 |
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