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| 1 | 美国临床药学学科60年发展概况显示文摘目的介绍美国临床药学领域进展情况,为我国临床药学学科发展提供借鉴参考。方法通过Pubmed、中国知网等工具检索介绍美国临床药学教育、毕业后培训以及临床药学实践相关文献,结合美国专家学术报告内容,了解美国临床药学学科进展情况。结果经过60年发展,美国临床药学教育、毕业后培训及临床药学实践已形成较完善体系。Pharm.D已成为药师从业的唯一准入学位。美国药学教育越来越重视对学生能力的培养,注重药学实践的实际需求。完成PGY1项目培训已被作为从事临床药学实践的基本要求,完成PGY2项目培训并取得专业资格证书已逐渐成为在特殊专业领域工作的必需要求。药学实践不断实现专科化、标准化。临床药学研究主要针对临床药学服务及相关问题,而不是进行基础性药学科学研究。临床药学研究促进了临床药学学科发展和临床药学服务的有效实施。通过药学专业委员会(BPS)的专业资格认证保证了临床药师的专业胜任力。结论美国临床药学学科体系经过60年发展已趋于完善,相关经验值得我们学习和借鉴。 | 余自成 Gary C YEE 朱珠 Wafa Y.DAHDAL | 2019 | 中国临床药学杂志2019，28，3： | 14 |
| 2 | Air/CO2 cooling garment: Description and benefits of use for subjects exposed to a hot and humid climate during physical activities显示文摘The severity of the hot and humid conditions to which miners are exposed increases as the depth of the work site increases.This can cause heat stress that can greatly affect the health and safety of workers.To resolve this,a cooling garment has been developed that uses an atmospheric discharge of liquid CO2 to create a cool microclimate with an average temperature of 12.5(±0.4)℃ beneath the garment.To evaluate the garment's cooling efficiency,19 male subjects participated in an experimental procedure.The two modes,cooling on and off,were compared.Significant physiological differences were found between the two modes after minute 27(p<0.05)until the end of the recovery phase for the heart rate(maximum difference of 10 beats per minute)and the internal body temperature(maximum difference of 0.33℃).It was found that the modes also affected the subjects'perceptions.The ON-mode was associated with better well-being and thermal comfort,and reduced humidity sensation.Perceptions of exertion were lower in the ON-mode condition from minute 2.The findings provide strong evidence of the ability of this cooling garment to reduce heat stress in hot and humid conditions similar to those encountered in deep mines. | Chady Al Sayed Ludwig Vinches Olivier Dupuy Wafa Douzi Benoit Dugue Stephane Halle | 2019 | International Journal of Mining Science and Technology2019，29，6： | 10 |
| 3 | Comparison of perceived pain and patients’ satisfaction with traditional local anesthesia and single tooth anesthesia: A randomized clinical trial显示文摘BACKGROUND Contemporary innovations in the area of local anesthesia have attempted to provide an absolutely pain free experience for patients.Since the introduction of Computer-Controlled Local Anesthetic Delivery Systems to dentistry,many studies have compared its efficacy and safety to conventional anesthesia.However,very few studies have compared single tooth anesthesia(STA)and traditional local anesthesia.AIM To compare pain rating,changes in blood pressure,and heart rate during the local anesthetic injection.The secondary objectives were to measure the patients’level of satisfaction and the differences in anesthetic efficiency between the STA system and traditional local infiltration.METHODS A randomized controlled trial was conducted and a total of 80 patients with dental restorative needs were enrolled for the study.The patients were evaluated for their general physical status and oral clinical findings before enrollment.Information regarding perceived pain,changes in heart rate and blood pressure,and patients’satisfaction was collected using an electronic data form and was analyzed using paired and unpaired t-tests.RESULTS No significant difference was noted in perceived pain(P=0.59)and systolic blood pressure(P=0.09)during anesthetic injection using both traditional and STA techniques.STA patients had a significantly higher heart rate during anesthesia,although a statistically significant difference was noted among the traditional anesthesia and the STA groups even before anesthesia.During the restorative procedure,less pain was perceived by STA patients on the Wong-Baker FACES pain scale,which was statistically significant(P<0.001).Analyses of post-procedure patient responses showed that STA patients had a significantly better treatment experience and preferred to have the same method of injection in the future(P=0.04).CONCLUSION STA system can provide less painful and more comfortable restorative treatment procedures in comparison to the traditional infiltration technique. | Mohammad I Al-Obaida Mehdiya Haider Rawan Hashim Wafa AlGheriri Sree Lalita Celur Samar A Al-Saleh Ebtissam M Al-Madi | 2019 | World Journal of Clinical Cases2019，7，19： | 8 |
| 4 | Mitochondrial dysfunction,oxidative stress and apoptotic induction in microglial BV-2 cells treated with sodium arsenate显示文摘The treatment of microglial BV-2 cells with sodium arsenate(As(V):0.1-400 μmol/L — 48 hr)induces a dose-dependent response.The neurotoxic effects of high concentrations of As(V)(100,200 and 400 μmol/L) are characterized by increased levels of mitochondrial complexesⅠ,Ⅱ,and Ⅳ followed by increased superoxide anion generation.Moreover,As(V) triggers an apoptotic mode of cell death,demonstrated by an apoptotic SubG1 peak,associated with an alteration of plasma membrane integrity.There is also a decrease in transmembrane mitochondrial potential and mitochondrial adenosine triphosphate ATP.It is therefore tempting to speculate that As(V) triggers mitochondrial dysfunction,which may lead to defective oxidative phosphorylation subsequently causing mitochondrial oxidative damage,which in turn induces an apoptotic mode of cell death. | Wafa Kharroubi Samia Hai Ahmed Thomas Nury Pierre Andreoletti Rachid Sakly Mohamed Hammami Gerard Lizard | 2017 | Journal of Environmental Sciences2017，29，1： | 5 |
| 5 | Determination of calorie and protein intake among acute and sub-acute traumatic brain injury patients显示文摘Purpose:Malnutrition is a common problem among hospitalized patients,especially among traumatic brain injury(TBI)patients.It is developed from hypermetabolism and the condition may worsen under the circumstance of underfeeding or incompatible dietary management.However,the data of nutrient intake especially calorie and protein among TBI patients were scarce.Hence,this study aimed to determine the calorie and protein intake among acute and sub-acute TBI patients receiving medical nutrition therapy in hospital Sultanah Nur Zahirah,Terengganu.Methods:This observational study involved 50 patients recruited from the neurosurgical ward.Method of 24 h dietary recall was utilized and combined with self-administered food diaries for 2-8 days.Food consumptions including calorie intake and protein intake were analyzed using Nutritionist PRO™(Woodinville,USA)and manual calculation based on the Malaysian food composition database(2015).Results:Patients consisted of 56%males and 44%females with the median age of 28.0(IQR=22.8-36.5)years,of which 92%were diagnosed as mild TBI and the remaining(8%)as moderate TBI.The Glasgow coma scale(GCS)was adopted to classify TBI severity with the score 13-15 being mild and 9-12 being moderate.The median length of hospital stay was 2(IQR=2.0e3.3)days.Calorie and protein intake improved significantly from day 1 to discharge day.However,the intake during discharge day was still considered as suboptimal,i.e.75%of calorie requirement,whilst the median protein intake was only 61.3%relative to protein requirement.Moreover,the average percentages of calorie and protein intakes throughout hospitalization were remarkably lower,i.e.52.2%and 41.0%,respectively.Conclusion:Although the calorie and protein intakes had increased from baseline,hospitalized TBI patients were still at a risk to develop malnutrition as the average intakes were considerably low as compared to their requirements.Optimum nutrient intakes especially calorie and protein are crucial to ensure optimum recovery process as well as to minimize risks of infection and complications. | Mohd Ibrahim Abdullah Aryati Ahmad Sharifah Wajihah Wafa Syed Saadun Tarek Wafa Ahmad Zubaidi Abdul Latif Noor Aini Mohd Yusoff Muhammad Khalis Jasmiad Nujaimin Udin Kartini Abdul Karim | 2020 | Chinese Journal of Traumatology2020，23，5： | 3 |
| 6 | ICG磁性PLGA纳米粒的制备及其在小鼠体内的脑靶向作用显示文摘目的:制备装载近红外荧光探针吲哚菁绿(ICG)的磁性聚乳酸-羟基乙酸共聚物(PLGA)纳米探针,并利用小动物活体成像技术观察ICG磁性PLGA纳米粒的脑靶向作用。方法:取ICG、PLGA和四氧化三铁纳米颗粒采用纳米沉淀法制备ICG磁性PLGA纳米粒,采用激光粒度分析仪检测其粒径、聚合物分散性指数(PDI)及Zeta电位分布,采用透射电镜观察其外貌和粒径大小,采用紫外可见吸收光谱法和原子吸收分光光度法测定ICG和四氧化三铁纳米粒的包封率和载药量;取NOD/SCID gamma(NSG)小鼠4只,其中头部放置和不放置磁铁各2只,同时尾静脉注射ICG磁性PLGA纳米粒后,采用小动物荧光成像仪观察活体及取脑前后活体动物、离体脑部的荧光成像,并利用系统自带的分子成像软件对离体脑部的近红外荧光进行定量分析。结果:本实验制备得到球形ICG磁性PLGA纳米粒,粒径为(172.77±2.14)nm,PDI为(0.225±0.015),Zeta电位为(-4.18±0.67)m V,ICG和四氧化三铁纳米粒的包封率分别为61.8%和40.1%,载药量分别为0.165%和0.042%;小动物活体荧光成像仪结果显示,ICG磁性PLGA纳米粒在磁场作用1 h后向NSG小鼠头部聚集;取脑部组织定量分析结果表明,经磁场作用的ICG磁性PLGA纳米粒在NSG小鼠头部的荧光强度约为无磁场作用NSG小鼠的1.2倍。结论:成功制备得到符合动物实验要求的球形ICG磁性PLGA纳米粒,且在磁场作用下具有一定的脑靶向作用。 | 杨畅 马广龙 张俊朗 Wafa Al-jamal 李勇军 | 2020 | 贵州医科大学学报2020，45，8： | 3 |
| 7 | Profiling cellular bioenergetics, glutathione levels, and caspase activities in stomach biopsies of patients with upper gastrointestinal symptoms显示文摘AIM: To measure biochemical parameters in stomach biopsies and test their suitability as diagnostic biomarkers for gastritis and precancerous lesions.METHODS: Biopsies were obtained from the stomachs of two groups of patients(n = 40) undergoing fiberoptic endoscopy due to upper gastrointestinal symptoms. In the first group(n = 17), only the corpus region was examined. Biopsies were processed for microscopic examination and measurement of mitochondrial O2 consumption(cellular respiration), cellular adenosine triphosphate(ATP), glutathione(GSH), and caspase activity. In the second group of patients(n = 23), both corpus and antral regions were studied. Some biopsies were processed for microscopic examination, while the others were used for measurements of cellular respiration and GSH level.RESULTS: Microscopic examinations of gastric corpus biopsies from 17 patients revealed normal mucosae in 8 patients, superficial gastritis in 7 patients, and chronic atrophic gastritis in 1 patient. In patients with normal histology, the rate(mean ± SD) of cellular respiration was 0.17 ± 0.02 μmol/L O2 min-1 mg-1, ATP content was 487 ± 493 pmol/mg, and GSH was 469 ± 98 pmol/mg. Caspase activity was detected in 3 out of 8 specimens. The values of ATP and caspase activity were highly variable. The presence of superficial gastritis had insignificant effects on the measured biomarkers. In the patient with atrophic gastritis, cellular respiration was high andATP was relatively low, suggesting uncoupling oxidative phosphorylation. In the second cohort of patients, the examined biopsies showed either normal or superficial gastritis. The rate of cellular respiration(O2. μmol/L min-1 mg-1) was slightly higher in the corpus than the antrum(0.18 ± 0.05 vs 0.15 ± 0.04, P = 0.019). The value of GSH was about the same in both tissues(310 ± 135 vs 322 ± 155, P = 0.692).CONCLUSION: The corpus mucosa was metabolically more active than the antrum tissue. The data in this study will help in understanding the pathophysiology of gastric mucosa. | Ali S Alfazari Bayan Al-Dabbagh Wafa Al-Dhaheri Mazen S Taha Ahmad A Chebli Eva M Fontagnier Zaher Koutoubi Jose Kochiyi Sherif M Karam Abdul-Kader Souid | 2015 | World Journal of Gastroenterology2015，21，2： | 2 |
| 8 | In vivo study of pomegranate(Punica granatum) peel extract efficacy against Giardia lamblia in infected experimental mice显示文摘Objective: To investigate the efficacy of pomegranate(Punica granatum) peel extract as an alternative treatment on the white laboratory mice against giardiasis.Methods: Experimental animals were divided into five groups, including Group A:control(infected untreated), Group B: infected and fed with pectin 7 days before infection, Group C: infected and fed with pectin starting from 7th day of infection,Group D: infected and fed with pomegranate peel extract 7 days before infection, and Group E: infected and fed with pomegranate peel extract starting from 7th day of infection.Results: Results from this study revealed that the prevention rate in the experimental groups reached approximately 50% by the 10 th day of using pomegranate peel extract.Moreover, stool cyst counts of groups showed a significant reduction in the shedding of cysts approximately 75.6% by day 20 post-infection. ELISA test showed a reduction in Giardia antigen in the stools of the experimental groups which received pomegranate peel extract. The cure rate of these groups was approximately 97.4% by 28 th day of infection.Conclusions: Our present findings indicated that the pomegranate peel extract proved to be valuable in prevention and treatment of Giardia lamblia infection. Further studies are required to determine the effective dose of pomegranate peel extract against Giardia lamblia infection. | Wafa Abdullah Al-Megrin | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，1： | 2 |
| 9 | Circle-criterion Based Nonlinear Observer Design for Sensorless Induction Motor Control显示文摘This paper deals with the design of a nonlinear observer for sensorless induction motor control. Based upon the circle criterion approach, a nonlinear observer is designed to estimate pertinent but unmeasurable state variables of the considered induction machine for sensorless control purpose. The observer gain matrices are computed as a solution of linear matrix inequalities(LMI) that ensure the stability conditions of the state observer error dynamics in the sense of Lyapunov concepts. Measured and estimated state variables can be exploited to perform a state feedback control of the machine system. The simulation results are presented to illustrate the effectiveness of the proposed approach for nonlinear observer design. | Wafa Bourbia Farid Berrezzek Bachir Bensaker | 2014 | International Journal of Automation and computing2014，11，6： | 2 |
| 10 | Differential Alterations of Lipid Status and Lipid Metabolism, Induction of Oxidative Stress by Sodium Arsenate in Female Rat's Liver and Kidney显示文摘Three groups of female rats(n=6 per group) were exposed to 1 and 10 mg/L of sodium arsenate for 90 days. The antioxidant and peroxidation parameters in kidney and liver tissues were evaluated, also the fatty acid composition were determined. In liver the synthesis pathway of n-3 polyunsaturated fatty acids(PUFA) seemed to be more affected than the n-6 PUFA, while in kidney the n-6 pathway was more affected. The Δ5 ‘desaturase index' was decreased in kidney. Both in liver and kidney an increase in the percentage of trans PUFA was observed, also we noted a disturbance in antioxidant parameters as SOD, GPx, CAT, and GSH(P<0.05). While the protein carbonyl levels increased only in liver. | Kharroubi Wafa Dhibi Madiha Chreif Imed Gérard Lizard Hammami Mohamed Sakly Rachid | 2015 | Biomedical and Environmental Sciences2015，28，11： | 2 |
| 11 | The engineering of doxorubicin-loaded liposome-quantum dot hybrids for cancer theranostics显示文摘Many studies have recently attempted to develop multifunctional nanoconstructs by integrating the superior fluorescence properties of quantum dots(QD) with therapeutic capabilities into a single vesicle for cancer theranostics. Liposomequantum dot(L-QD) hybrid vesicles have shown promising potential for the construction of multifunctional nanoconstructs for cancer imaging and therapy. To fulfil such a potential, we report here the further functionalization of L-QD hybrid vesicles with therapeutic capabilities by loading anticancer drug doxorubicin(Dox) into their aqueous core. L-QD hybrid vesicles are first engineered by the incorporation of TOPO-capped, CdSe/ZnS QD into the lipid bilayers of DSPC:Chol:DSPEPEG2000, followed by Dox loading using the pH-gradient technique. The loading efficiency of Dox into L-QD hybrid vesicles is achieved up to 97%, comparable to liposome control. All these evidences prove that the incorporation of QD into the lipid bilayer does not affect Dox loading through the lipid membrane of liposomes using the pH-gradient technique. Moreover, the release study shows that Dox release profile can be modulated simply by changing lipid composition.In conclusion, the Dox-loaded L-QD hybrid vesicles presented here constitute a promising multifunctional nanoconstruct capable of transporting combinations of therapeutic and diagnostic modalities. | 田博文 Wafa' T. Al-Jamal Kostas Kostarelos | 2014 | Chinese Physics B2014，23，8： | 2 |
| 12 | A Challenging Approach to Improve the Low Affinity of Acrylic Fibres to Be Successfully Dyed with a Bio-Colorant Extracted from Grape Marc显示文摘Acrylic fibres are highly crystalline and non-polar polymers,which makes their dyeing a very difficult step that poses real technical challenges.In order to overcome this concern,it is intended in this paper to modify acrylic fibers by different methods namely cationisation using the Crosscolor DRT then amidoximation using hydroxylamine hydrochloride and ammonium acetate.The resulted samples were dyed then with the bio-colorant extracted from grape marc.The effect of the pretreatment on fibers fine structure using X-ray diffraction and the scanning electron microscope(SEM)images and its correlation with the colour strength of the dyed fabrics was investigated.The dyeing parameters,such as dye bath pH and temperature on the performances of this dyeing process were studied.Good dyeing qualities and new shades varying from brown to grey and dark green have been obtained following process optimization,mordanting and modification of acrylic fibers by the technique of cationisation. | Noureddine Baaka Manel Ben Ticha Wafa Haddar Mohamed Farouk Mhenni | 2019 | Journal of Renewable Materials2019，7，3： | 2 |
| 13 | Tobacco use and risk of myocardial infarction in 52 countries in the INTERHEART study: a case-control study显示文摘 | Koon K Teo Stephanie Ounpuu Steven Hawken MR Pandey Vicent Valentin David Hunt Rafael Diaz Wafa Rashed Rosario Freeman Lixin Jiang Xiaofei Zhang Salim Yusuf | 2006 | The Lancet . 2006 (9536)2006，，9536： | 2 |
| 14 | Oral administration of Eucalyptus globulus extract reduces the alloxan-induced oxidative stress in rats显示文摘 | Soussi Ahlem Hamden Khaled Marouane Wafa Bezzine Sofiane Damak Mohamed Murat Jean-Claude El Feki Abdelfattah | 2009 | Chemico-Biological Interactions2009，，1： | 2 |
| 15 | 染色体异常致反复和后代5p12-15.3三体:一对叙利亚夫妇报道及文献复习(英文)显示文摘在本研究中,我们介绍一叙利亚夫妻发生孕早期反复流产、胎儿畸形和/或新生儿死亡。经检查,父亲表型正常,有一个平衡的染色体易位t(5;15),在无精子症因子(AZF)b座位s Y125基因发生了微缺失而且其伴有MTHFRC677T纯合子基因多态性。值得注意的是,他的妻子则伴有MTHFRA1298C纯合子基因多态性。这对夫妻经历了两次流产,有2个夭折的孩子均为严重畸形,为5号染色体短臂部分三体。夫妻结婚10年后没有任何存活后代。 | Walid AL-ACHKAR Faten Moassass Ayman Al-Ablog Thomas Liehr Xiaobo Fan Abdulsamad Wafa | 2015 | 中华男科学杂志2015，21，3： | 2 |
| 16 | Quantification of three di mensional vertebral rotation in scoliosis: What are the true values? 显示文摘 | Wafa S Francois L Jean LD | 1995 | Spine1995，20，7： | 1 |
| 17 | Massive vault necrosis with bladder fistula after uterine artery embolisation显示文摘 | Nasr El-Din MH Wafa GA | 2003 | BJOG2003，110，2： | 1 |
| 18 | Shear behavior of high-strength fiber reinforced concrete beams 显示文摘 | ASHOUR S A HASANAIN G S WAFA F F | 1992 | ACI Struct J1992，89，2： | 1 |
| 19 | Massive vault necrosis with bladder fistula after uterine artery embolization 显示文摘 | EI-Shalakany AH Nasr EI-Din MH Wafa GA | 2003 | Interventional Radiology2003，11，： | 1 |
| 20 | Prevention of transfusion-associated graft-versus-host disease by photochemical treatment显示文摘 | Wafa T Reames A | 1999 | Blood1999，93，： | 1 |
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