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| 1 | Keratinocytes costimulate naive human T cells via CD2: a potential target to prevent the development of proinflammatory Th1 cells in the skin显示文摘The interplay between keratinocytes and immune cells,especially T cells,plays an important role in the pathogenesis of chronic inflammatory skin diseases.During psoriasis,keratinocytes attract T cells by releasing chemokines,while skin-infiltrating selfreactive T cells secrete proinflammatory cytokines,e.g.,IFN γand IL-17A,that cause epidermal hyperplasia.Similarly,in chronic graftversus-host disease,allogenic IFN γ-producing Th1/Tc1 and IL-17-producing Th17/Tc17 cells are recruited by keratinocyte-derived chemokines and accumulate in the skin.However,whether keratinocytes act as nonprofessional antigen-presenting cells to directly activate naive human T cells in the epidermis remains unknown.Here,we demonstrate that under proinflammatory conditions,primary human keratinocytes indeed activate naive human T cells.This activation required cell contact and costimulatory signaling via CD58/CD2 and CD54/LFA-1.Naive T cells costimulated by keratinocytes selectively differentiated into Th1 and Th17 cells.In particular,keratinocyte-initiated Th1 differentiation was dependent on costimulation through CD58/CD2.The latter molecule initiated STAT1 signaling and IFN γproduction in T cells.Costimulation of T cells by keratinocytes resulting in Th1 and Th17 differentiation represents a new explanation for the local enrichment of Th1 and Th17 cells in the skin of patients with a chronic inflammatory skin disease.Consequently,local interference with T cell–keratinocyte interactions may represent a novel strategy for the treatment of Th1 and Th17 cell-driven skin diseases. | Christian Orlik Daniel Deibel Johanna Küblbeck Emre Balta Sabina Ganskih Jüri Habicht Beate Niesler Jutta Schröder-Braunstein Knut Schäkel Guido Wabnitz Yvonne Samstag | 2020 | Cellular & Molecular Immunology2020，17，4： | 4 |
| 2 | Advances in femtosecond laser direct writing of fiber Bragg gratings in multicore fibers:technology,sensor and laser applications显示文摘In this article,we review recent advances in the technology of writing fiber Bragg gratings(FBGs)in selected cores of multicore fibers(MCFs)by using femtosecond laser pulses.The writing technology of such a key element as the FBG opens up wide opportunities for the creation of next generation fiber lasers and sensors based on MCFs.The advantages of the technology are shown by using the examples of 3D shape sensors,acoustic emission sensors with spatially multiplexed channels,as well as multicore fiber Raman lasers. | Alexey Wolf Alexander Dostovalov Kirill Bronnikov Mikhail Skvortsov Stefan Wabnitz Sergey Babin | 2022 | Opto-Electronic Advances2022，5，4： | 2 |
| 3 | Modulational polarization instability of light in a nonlinear birefingent dispersive medium显示文摘 | Wabnitz S | 1998 | Physical Review A1998，38，4： | 1 |
| 4 | Correlation between preo- perative symptom scores, quality-of-life questionnaires and staging with computed tomography in patients with chronic rhinosinusitis 显示文摘 | Wabnitz DA Nair S Wormald PJ | 2005 | Am J Rhinol2005，19，1： | 1 |
| 5 | Correlation between preoperative symptom scores,quality-oflife questionnaires,and staging with computed tomography in patients with chronic rhinosinusitis显示文摘 | WABNITZ D A NAIR S WORMALD P J | 2005 | Am J Rhinol2005，19，： | 1 |
| 6 | Pathway leading to the formation of anthocyanin-vinylphenol adducts and related pigments in red wines显示文摘 | Schwarz M Wabnitz T C Winterhalter P | 2003 | Journal of Agricultural and Food Chemistry2003，，51： | 1 |
| 7 | Non-invasive simultaneous recording of neuronal and vascular signals in subacute ischemic stroke显示文摘 | Leistner S Sander-Thoemmes T Wabnitz H | 2011 | Biomed Tech (Berl)2011，56，2： | 1 |
| 8 | Correlation between preoperative symptom scores, quality-of-life questionnaires, and staging with computed tomography in patients with chronic rhinosinusitis 显示文摘 | WABNITZ D A NAIR S WORMALD P J | 2005 | Am J Rhinol2005，19，1： | 1 |
| 9 | Convenient synthesis of Cbz- protected fl-amino ketones by a copper-catalyzed conju- gate addition reaction 显示文摘 | Wabnitz T C Spencer J B | 2002 | Tetrahedron Lett2002，43，： | 1 |
| 10 | Ultrashort train generation through induced modulation polarization instability in a birefringent Kerr-like medium 显示文摘 | TRILLO S WABNITZ S | 1989 | J O S A1989，6，2： | 1 |
| 11 | Pulse self-switching in optical fiber Bragg gratings 显示文摘 | S Wabnitz | 1995 | Optics Communications1995，114，： | 1 |
| 12 | Functional analysis of bispecific antibody (EpCAMxCD3)-mediated T-lymphocyte and cancer cell interaction by single-cell force spectroscopy显示文摘 | Hoffmann S C Wabnitz G H Samstag Y | | 0，，09： | 1 |
| 13 | Costimulation induced phosphorylation of L-plastin facilitates surface transport of the T cell activation molecules CD69 and CD25显示文摘 | Wabnitz GH Kocher T Lohneia P | 2007 | Euro J Immunology2007，37，： | 1 |
| 14 | Multiple ionization of atom clusters by intense soft X-ray from a free-electron laser显示文摘 | Wabnitz H Bitmer L | 2002 | Nature2002，420，6915： | 1 |
| 15 | Postoperative pain followingcoblation tonsillectomy : randomized clinical trial 显示文摘 | Polites N Joniau S Wabnitz D | 2006 | ANZ J Surg2006，76，4： | 1 |
| 16 | Modulation polarization instability of light in a nonlinear birefringence dispersive medium 显示文摘 | STEFAN WABNITZ | 1988 | Physical Review A1988，38，4： | 1 |
| 17 | Modulation polarization instability of light in a nonlinear birefringent dispersive medium显示文摘 | Stefan Wabnitz | 1988 | Physical Review A1988，38，4： | 1 |
| 18 | Modulational polarzation instability of light in a nonlinear birefringent dispersive medium显示文摘 | Stefan Wabnitz | 1988 | Physical Review A1988，38，4： | 1 |
| 19 | Drug screening of pharmaceutical discovery compounds by micro-size exclusion chromatography/mass spectrometry 显示文摘 | Wabnitz PA Loo JA | 2002 | Rapid Commun Mass Spectrom2002，16，2： | 1 |
| 20 | Soliton switching in fiber nonlinear directional couplers显示文摘 | Trillo S Wabnitz S Wright E M | 1988 | Optics Letters1988，13，8： | 1 |
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