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| 1 | 酒精相关性肝病的研究进展和临床现状显示文摘酒精相关性肝病的研究进展和临床现状张育明,段芳龄,吴醒民JameswWoodJosephRBertino酒精问题目有人类文字记载以来就已存在,唯其与肝病的关系只是从17世纪才引起人们的注意(4-7)。肝硬化在酗酒人群中的发病率高于非饮酒人群七倍以上(... | 张育明 段芳龄 吴醒民 James w wood Joseph R Bertinno | 1996 | 胃肠病学和肝病学杂志1996，5，3： | 8 |
| 2 | Blood glucose changes surrounding initiation of tumor-necrosis factor inhibitors and conventional disease-modifying anti-rheumatic drugs in veterans with rheumatoid arthritis显示文摘AIM To determine the scope of acute hypoglycemic effects for certain anti-rheumatic medications in a large retrospective observational study. METHODS Patients enrolled in the Veterans Affairs Rheumatoid Arthritis (VARA) registry were selected who, during follow-up, initiated treatment with tumor necrosis factor inhibitors (TNFi's, including etanercept, adalimumab, infliximab, golimumab, or certolizumab), prednisone, or conventional disease-modifying anti-rheumatic drugs(DMARDs), and for whom proximate random blood glucose (RBG) measurements were available within a window 2-wk prior to, and 6 mo following, medication initiation. Similar data were obtained for patients with proximate values available for glycosylated hemoglobin A1C values within a window 2 mo preceding, and 12 mo following, medication initiation. RBG and A1C measurements were compared before and after initiation events using paired t-tests, and multivariate regression analysis was performed including established comorbidities and demographics.RESULTS Two thousands one hundred and eleven patients contributed at least one proximate measurement surrounding the initiation of any examined medication. A significant decrease in RBG was noted surrounding 653 individual hydroxychloroquine-initiation events(-3.68 mg/dL, P = 0.04), while an increase was noted for RBG surrounding 665 prednisone-initiation events(+5.85 mg/d L, P < 0.01). A statistically significant decrease in A1C was noted for sulfasalazine initiation, as measured by 49 individual initiation events(-0.70%, P < 0.01). Multivariate regression analyses, using methotrexate as the referent, suggest sulfasalazine (β =-0.58, P = 0.01) and hydroxychloroquine(β =-5.78, P = 0.01) use as predictors of lower post-medicationinitiation RBG and A1C values, respectively. Analysis by drug class suggested prednisone (or glucocorticoids) as predictive of higher medication-initiation event RBG among all start events as compared to DMARDs, while this analysis did not show any drug class-level effect for TNFi. A diagnosis of congestive heart failure(β = 4.69, P = 0.03) was predictive for higher post-initiation RBG values among all medication-initiation events.CONCLUSION No statistically significant hypoglycemic effects surrounding TNFi initiation were observed in this large cohort. Sulfasalazine and hydroxychloroquine may have epidemiologically significant acute hypoglycemic effects. | Patrick R Wood Evan Manning Joshua F Baker Bryant England Lisa Davis Grant W Cannon Ted R Mikuls Liron Caplan | 2018 | World Journal of Diabetes2018，9，2： | 8 |
| 3 | Utilization of longitudinal ultrasound to quantify joint soft-tissue changes in a mouse model of posttraumatic osteoarthritis显示文摘To assess the utility of longitudinal ultrasound(US) to quantify volumetric changes in joint soft tissues during the progression of posttraumatic osteoarthritis(PTOA) in mice, and validate the US results with histological findings. A longitudinal cohort of 3-month-old wild-type C57 BL/6 male mice received the Hulth-Telhag surgical procedure on right knee to induce PTOA, and sham surgery on their left knee as control. US scans were performed on both knees before, 2, 4, 6, and 8 weeks post-surgery. Joint space volume and Power-Doppler(PD) volume were obtained from US images via Amira software. A parallel cross-sectional cohort of mice was killed at each US time point, and knee joints were subjected to histological analysis to obtain synovial soft-tissue area and OARSI scores. The correlation between US joint space volume and histological synovial soft-tissue area or OARSI score was assessed via linear regression analysis. US images indicated increased joint space volume in PTOA joints over time, which was associated with synovial inflammation and cartilage damage by histology. These changes started from 2 weeks post-surgery and gradually became more severe. No change was detected in sham joints. Increased joint space volume was significantly correlated with increased synovial soft-tissue area and the OARSI score(P o 0.001). PD signal was detected in the joint space of PTOA joints at 6 weeks post-surgery, which was consistent with the location of blood vessels that stained positively for CD31 and alpha-smooth muscle actin in the synovium.This study indicates that US is a cost-effective longitudinal outcome measure of volumetric and vascular changes in joint soft tissues during PTOA progression in mice, which positively correlates with synovial inflammation and cartilage damage. | Hao Xu Echoe M Bouta Ronald W Wood Edward M Schwarz Yongjun Wang Lianping Xing | 2017 | Bone Research2017，5，3： | 7 |
| 4 | Hepatitis B and C infection and liver disease trends among human immunodeficiency virus-infected individuals显示文摘AIM:To examine trends in and correlates of liver disease and viral hepatitis in an human immunodeficiency virus (HIV)-infected cohort. METHODS:The multi-site adult/adolescent spectrum of HIV-related diseases (ASD) followed 29 490 HIVinfected individuals receiving medical care in 11 U.S. metropolitan areas for an average of 2.4 years,and a total of 69 487 person-years,between 1998 and 2004. ASD collected data on the presentation,treatment,and outcomes of HIV,including liver disease,hepatitis screening,and hepatitis diagnoses. RESULTS:Incident liver disease,chronic hepatitis B virus (HBV),and hepatitis C virus (HCV) were diagnosed in 0.9,1.8,and 4.7 per 100 person-years. HBV and HCV screening increased from fewer than 20% to over 60% during this period of observation (P < 0.001). Deaths occurred in 57% of those diagnosed with liver disease relative to 15% overall (P < 0.001). Overall 10% of deaths occurred among individuals with a diagnosis of liver disease. Despite care guidelines promoting screening and vaccination for HBV and screening for HCV,screening and vaccination were not universally conducted or,if conducted,not documented. CONCLUSION:Due to high rates of incident liver disease,viral hepatitis screening,vaccination,and treatment among HIV-infected individuals should be a priority. | Susan E Buskin Elizabeth A Barash John D Scott David M Aboulafia Robert W Wood | 2011 | World Journal of Gastroenterology2011，17，14： | 2 |
| 5 | Novel and economical purification of recombinant proteins:intein-mediated protein purification using in vivo polyhydroxybutyrate (PHB) matrix association显示文摘 | BANKI M R GERNGROSS T U WOOD D W | 2005 | Protein Science2005，14，： | 1 |
| 6 | Clinical evaluation of the BDProbe Tec ET system for rapid detection of My- cobacterium tuberculosis 显示文摘 | Bergmann JS Keating W E Woods GL | 2000 | J Clin Microbiol2000，38，2： | 1 |
| 7 | Effect of feeding organic acids on selected intestinal content measurements at varying times postweaning in pigs显示文摘 | Risley C R Kornegay E T Lindemann M D Wood C M Eigel W N | 1992 | Journal of Animal Science1992，70，： | 1 |
| 8 | Genotyping Taenia tapeworms by singles-trand conformation pol-ymorphism of mitochondrial DNA显示文摘 | GASSER R B ZHU X WOODS W | 1999 | Electrophore-sis1999，20，14： | 1 |
| 9 | Simultaneous deconvolution and wavelet inversion as a global optimization显示文摘 | Wood W T | 1999 | Geophysics1999，64，4： | 1 |
| 10 | Effects of transverse air flow on burning rates of rectangular methanol pool fires显示文摘 | Woods J A R Fleck B A Kostiuk L W | 2006 | Combustion and Flame2006，146，12： | 1 |
| 11 | An alpha modication of Newmark's method显示文摘 | Wood W L Bossak M Zienkiewicz O C | 1980 | International Journal for Numerical Methods in Engineering1980，15，： | 1 |
| 12 | Suppression of tu- morigenicity of breast cancer cells by an epithelial cell adhe- sion molecule (C-CAM1): the adhesion and growth suppression are mediated by different domains显示文摘 | LUO W WOOD C G EARLEY K | 1997 | Oncngene1997，14，14： | 1 |
| 13 | Decision-based Con-ceptual Design:Modeling and Navigating Hetero-geneous Design Spaces显示文摘 | Wood W H Agogino A M | 2005 | Transactions of theASME Journal of Mechanical Design2005，127，1： | 1 |
| 14 | ASCO/SSO re-view of current role of risk-reducing surgery in common he-reditary cancer syndromes显示文摘 | Guillem J G Wood W C Moley J F | 2006 | J Clin Oncol2006，24，28： | 1 |
| 15 | A filter based bit allocation scheme for sub-band compression of HDTV显示文摘 | J W Woods T Naveen | 1992 | IEEE Transactions on Image Processing1992，1，3： | 1 |
| 16 | Effect of calcium and starch additions on ration digestibility by steers 显示文摘 | Varner L W Woods W | 1972 | J Anim Sci1972，35，： | 1 |
| 17 | Characterization of Arabidopsis AtAMT2, a high-affinity ammonium transporter of the plasma membrane 显示文摘 | Sohlenkamp C Wood C C Roeb G W | 2002 | Plant Physiology2002，130，4： | 1 |
| 18 | An avian influenza vires of H10 subtype that is highly pathogenic for chickens, but lacks multiple basic amino acids at the haemagglutinin cleavage site 显示文摘 | Wood G W Banks J Strong I | 1996 | Avian Pathol1996，25，4： | 1 |
| 19 | Development of industrial-medium-required elimination of the 2,3-butanediol fermentation pathway to maintain ethanol yield in an ethanologenic strain of Klebsiella oxytoca显示文摘 | WOOD B E YOMANO L P YORK S W | 2005 | Biotechnology Progress2005，21，5： | 1 |
| 20 | Simple bioseparations using self-cleaving elastin-like polypeptide tags 显示文摘 | BANKI M R FENG L WOOD D W | 2005 | Nature Methods2005，2，： | 1 |
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