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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Strengthening mecha-nisms of bone bonding to crystallinc hydroxyapatite in Vivo显示文摘 | Chen QZ Wong CT Lu WW | 2004 | Biomaterials2004，25，18： | 1 |
| 3 | In vivo cancellous bone remodeling on a Strontium-containing hydroxyapatiteCSr-HA) bioactive cement显示文摘 | Wong CT Lu WW Chan WK | 2004 | Biomed Mater Res2004，68，3： | 1 |
| 4 | Galphal6 interacts with Class I A phosphatidylinositol 3-kinases and inhibits Akt signaling显示文摘 | Yeung WW Wong YH | 2010 | Cell Signal2010，22，9： | 1 |
| 5 | CED3 protease nomenclature显示文摘 | Alnemri ES Wong WW | 1996 | Cell1996，87，： | 1 |
| 6 | Monitoring childhood obesity: as?sessment of the weight/height index显示文摘 | Ellis KJ Abrams SA Wong WW | 1999 | AmJ Epidemiol1999，，： | 1 |
| 7 | Bcl-2 family proteins:the sentinels of the mitochondrial apoptosis pathway显示文摘 | Wong WW Puthalakath H | 2008 | IUBMB Life2008，60，6： | 1 |
| 8 | Epidemiology of community-Acquired Staphylococcus aureus bacteremia显示文摘 | Chi CY Wong WW Fung CP | 2004 | J Microbiol Immunol Infect2004，37，1： | 1 |
| 9 | Clinical analysis of mycobacterium tuberculosis infection in patients with acquired immunodeficiency syndrome 显示文摘 | Chiu CP Wong WW Kuo B | 1999 | J Microbiol Immunol Infect1999，32，： | 1 |
| 10 | Drug adherence and the incidence of coronary heart disease-and stroke-specific mortality among 218,047 patients newly prescribed an antihypertensive medication'a five-year cohort study显示文摘 | Wong MC1 Tam WW Cheung CS | 2013 | Int J Cardiol2013，168，2： | 1 |
| 11 | Progression of middle cerebral artery occlusive disease and its relationship with further vascular events after stroke显示文摘 | Wong KS Lam WW Chan YL | 2002 | Stroke2002，33，2： | 1 |
| 12 | Central venous catheter-related Stenotrophomonas maltophilia bacteraemia and associated relapsing bacteraemia in haematology and oncology patients显示文摘 | Lai CH Wong WW Chin C | 2006 | Clin Microbiol Infect2006，12，10： | 1 |
| 13 | Craniofacial growth in untreated skeletal Class Ⅱ subjects:a longitudinal study显示文摘 | Chung CH Wong WW | 2002 | Am J Orthod Dentofacial Orthop2002，122，6： | 1 |
| 14 | Endothelial dysfunction:The com- mon consequence in diabetes and hypertension 显示文摘 | Tak WW Wong Ling S etal | 2010 | Cardiovasc Pharmacol2010，55，： | 1 |
| 15 | Analysis of outcome in patients reirradiated for brain metastases显示文摘 | Wong WW schild SE Sawyer TE | 1996 | Int J Radiat Biol phys1996，34，： | 1 |
| 16 | Middle cerebral artery atherosclerosis:histological comparison between plaques associated with and not associated with infarct in a postmortem study显示文摘 | Chert XY Wong KS Lam WW | 2008 | Cerebrovasc Dis2008，25，： | 1 |
| 17 | Primary non-Hodgkin lymphoma of the breast: The Mayo Clinic Experience 显示文摘 | Wong WW Schild SE Halyard MY | 2002 | J Surg Oncol2002，80，1： | 1 |
| 18 | Validation of the Chinese version of the short - form Supportive Care Needs Survey Questionnaire ( SCNS - SF34 - C) 显示文摘 | AU A Lam WW Wong A | 2011 | Psycho - Oncology2011，20，12： | 1 |
| 19 | Primary non Hodgkin lymphoma of the breast:the Mayo clinic experience显示文摘 | Wong WW Schild SE Halyard MY | 2002 | J Surg Oncol2002，80，1： | 1 |
| 20 | Synergism in replication of cymbidiym mosaic potexvirus(CymMV)and odontoglossum ringspot tobamovirus(ORSV)RNA in orchid protoplasts显示文摘 | Hu WW Wong SM Goh CJ | 1998 | Arch Virol1998，143，7： | 1 |
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