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| 1 | 皮质下小血管病诊断的共识声明显示文摘血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病(Binswanger's disease, BD)的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组,存在缺氧缺血、腔隙性梗死和炎症,它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物,这将有助于诊断以及将来协作性治疗试验的患者选择。 | Gary A Rosenberg Anders Wallin Joanna M Wardlaw Hugh S Markus Joan Montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel Martin Dichgans Marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师 张劼 陈涵丰 俞娅美 徐子奇 罗本燕 | 2016 | 国际脑血管病杂志2016，24，6： | 18 |
| 2 | Roles of micro RNA-140 in stem cell-associated early stage breast cancer显示文摘An increasing body of evidence supports a stepwise model for progression of breast cancer from ductal carcinoma in situ(DCIS) to invasive ductal carcinoma(IDC). Due to the high level of DCIS heterogeneity, we cannot currently predict which patients are at highest risk for disease recurrence or progression. The mechanisms of progression are still largely unknown, however cancer stem cell populations in DCIS lesions may serve as malignant precursor cells intimately involved in progression. While genetic and epigenetic alterations found in DCIS are often shared by IDC, m RNA and mi RNA expression profiles are significantly altered. Therapeutic targeting of cancer stem cell pathways and differentially expressed mi RNA could have significant clinical benefit. As tumor grade increases, mi RNA-140 is progressively downregulated. mi R-140 plays an important tumor suppressive role in the Wnt, SOX2 and SOX9 stem cell regulator pathways. Downregulation of mi R-140 removes inhibition of these pathways, leading to higher cancer stem cell populations and breast cancer progression. mi R-140 downregulation is mediated through both an estrogen response element in the mi R-140 promoter region and differential methylation of Cp G islands. These mechanisms are novel targets for epigenetic therapy to activate tumor suppressor signaling via mi R-140. Additionally, we briefly explored the emerging role of exosomes in mediating intercellular mi R-140 signaling. The purpose of this review is to examine the cancer stem cell signaling pathways involved in breast cancer progression, and the role of dysregulation of mi R-140 in regulating DCIS to IDC transition. | Benjamin Wolfson Gabriel Eades Qun Zhou | 2014 | World Journal of Stem Cells2014，6，5： | 11 |
| 3 | Nitric Oxide:from a mysterious labile factor to the molecule of the Nobel Prize Recent progress in nitric oxide research显示文摘NO is now known to be an important messenger molecule in biology.It regulates a variety of functions within cells and tissues including vasodilation, neurotransmission and immunological process. This review will focus on the nitric oxide synthase gene family and recent progress on molecular genetic analysis of NOS1, NOS2 and N0S3 genes. | XU WEI MING LI ZHI LIU (The Wolfson Institute for Biomedical Research, The Rayne Institute, University College London, 5 University Street,London WC1E 6JJ) | 1998 | Cell Research1998，8，4： | 11 |
| 4 | Mechanisms of the alternative activation of macrophages and non-coding RNAs in the development of radiation-induced lung fibrosis显示文摘Radiation-induced lung fibrosis(RILF) is a common side effect of thoracic irradiation therapy and leads to high mortality rates after cancer treatment. Radiation injury induces inflammatory M1 macrophage polarization leading to radiation pneumonitis, the first stage of RILF progression. Fibrosis occurs due to the transition of M1 macrophages to the anti-inflammatory pro-fibrotic M2 phenotype, and the resulting imbalance of macrophage regulated inflammatory signaling. Non-coding RNA signaling has been shown to play a large role in the regulation of the M2 mediated signaling pathways that are associated with the development and progression of fibrosis. While many studies show the link between M2 macrophages and fibrosis, there are only a few that explore their distinct role and the regulation of their signaling by non-coding RNA in RILF. In this review we summarize the current body of knowledge describing the roles of M2 macrophages in RILF, with an emphasis on the expression and functions of non-coding RNAs. | Nadire Duru Benjamin Wolfson Qun Zhou | 2016 | World Journal of Biological Chemistry2016，7，4： | 9 |
| 5 | Adipocyte activation of cancer stem cell signaling in breast cancer显示文摘Signaling within the tumor microenvironment has a critical role in cancer initiation and progression. Adipocytes, one of the major components of the breast microenvironment,have been shown to provide pro-tumorigenic signals that promote cancer cell proliferation and invasiveness in vitro and tumorigenicity in vivo. Adipocyte secreted factors such as leptin and interleukin-6(IL-6) have a paracrine effect on breast cancer cells. In adipocyte-adjacent breast cancer cells, the leptin and IL-6 signaling pathways activate janus kinase 2/signal transducer and activatorof transcription 5, promoting the epithelial-mesenchymal transition, and upregulating stemness regulators such as Notch, Wnt and the Sex determining region Y-box 2/octamer binding transcription factor 4/Nanog signaling axis. In this review we will summarize the major signaling pathways that regulate cancer stem cells in breast cancer and describe the effects that adipocyte secreted IL-6 and leptin have on breast cancer stem cell signaling. Finally we will introduce a new potential treatment paradigm of inhibiting the adipocyte-breast cancer cell signaling via targeting the IL-6 or leptin pathways. | Benjamin Wolfson Gabriel Eades Qun Zhou | 2015 | World Journal of Biological Chemistry2015，6，2： | 6 |
| 6 | Cellular, physiological and pathological aspects of the long non-coding RNA NEAT1显示文摘哺乳动物的染色体的多数被发现了被抄录进非编码的 RNA 的背景。非编码的 RNA 的一个范畴基于他们比 200 核苷酸大的抄本尺寸作为长非编码的 RNA (lncRNAs ) 被分类。成长证据证明了 lncRNAs 不是垃圾抄本并且在生物过程的多重方面起规章的作用。lncRNA 表示的 Dysregulation 也被连接了到疾病,特别地癌症。因此, lncRNAs 的研究在医药研究的领域里吸引了重要兴趣。原子充实的丰富的抄本 1 (NEAT1 ) ,原子 lncRNA,最近作为涉及各种各样的细胞的过程,生理的回答,发展过程,和疾病开发和前进的一个关键管理者出现了。这评论将总结并且讨论的目的关于在原子 paraspeckle,细胞的小径,和生理的回答和进程的函数的 NEAT1 的角色的最近的调查结果。特别地,大多数最近报导关于在癌症的 deregulated NEAT1 的病理学的角色的研究在这评论被加亮。我们执行了系统的文学的方法用 Pubmed 搜索引擎寻找。在过去的 8 年出版的研究(在 2009 年 1 月和 2016 年 8 月之间) 是文学评论的来源。下列关键词被使用:原子充实的丰富的抄本 1, NEAT1,和 paraspeckles。结果 Pubmed 搜索识别了与评论的话题有关的 34 篇文章。在识别文学之中, 13 篇文章报导与 NEAT1 和八篇文章的细胞的功能有关的调查结果是 NEAT1 的生理的功能的调查。留下 13 篇文章是在癌症的 NEAT1 的角色的研究。在 NEAT1 研究的结论最近的进展在各种各样的生物过程揭示 NEAT1 的多功能的角色,它在它在原子 paraspeckles 的角色以外。最近的研究也显示 NEAT1 功能的 dysregulation 贡献各种各样的癌症的发展和前进。更多的调查将被需要探讨考虑 NEAT1 怎么执行它的细胞、生理的功能并且 NEAT1 dysregulation 怎么导致 tumorigenesis 的详细机制,并且在癌症诊断,预后和治疗作为一个目标探索 NEAT1 的潜力。 | Pang-Kuo Lo Benjamin Wolfson Qun Zhou | 2016 | Frontiers in Biology2016，11，6： | 5 |
| 7 | Cancer stem cells and early stage basal-like breast cancer显示文摘Ductal carcinoma in situ(DCIS) is a category of early stage, non-invasive breast tumor defined by the intraductal proliferation of malignant breast epithelial cells. DCIS is a heterogeneous disease composed of multiple molecular subtypes including luminal, HER2 and basal-like types, which are characterized by immunohistochemical analyses and gene expression profiling. Following surgical and radiation therapies, patients with luminal-type, estrogen receptor-positive DCIS breast tumors can benefit from adjuvant endocrine-based treatment. However, there are no available targeted therapies for patients with basal-like DCIS(BL-DCIS) tumors due to their frequent lack of endocrine receptors and HER2 amplification, rendering them potentially susceptible to recurrence. Moreover, multiple lines of evidence suggest that DCIS is a non-obligate precursor of invasive breast carcinoma. This raises the possibility that targeting precursor BL-DCIS is a promising strategy to prevent BL-DCIS patients from the development of invasive basal-like breast cancer. An accumulating body of evidence demonstrates the existence of cancer stemlike cells(CSCs) in BL-DCIS, which potentially determine the features of BL-DCIS and their ability to progress into invasive cancer. This review encompasses the current knowledge in regard to the characteristics of BL-DCIS, identification of CSCs, and their biological properties in BL-DCIS. We summarize recently discovered relevant molecular signaling alterations that promote the generation of CSCs in BL-DCIS and the progression of BLDCIS to invasive breast cancer, as well as the influence of the tissue microenvironment on CSCs and the invasive transition. Finally, we discuss the translational implications of these findings for the prognosis and prevention of BL-DCIS relapse and progression. | Pang-Kuo Lo Benjamin Wolfson Qun Zhou | 2016 | World Journal of Obstetrics and Gynecology2016，5，2： | 3 |
| 8 | Research in high flow therapy: Mechanisms of action显示文摘 | Kevin Dysart Thomas L. Miller Marla R. Wolfson Thomas H. Shaffer | 2009 | Respiratory Medicine2009，，10： | 2 |
| 9 | The signaling hubs at the crossroad of longevity and age-related disease networks显示文摘 | Wolfson M Budovsky A Tacutu R | 2009 | Int J Biochem Cell Biol2009，41，3： | 1 |
| 10 | Updating and Querying Databases That Track Mobile Units显示文摘 | Wolfson O Sistla A P Chamberlain S | 1999 | Distributed and Parallel Databases1999，7，3： | 1 |
| 11 | A phase I study of docetaxel as a radio-sensitizer for locally advanced squamous cell cervical cancer显示文摘 | Alvarez E A Wolfson A H Pearson J M | 2009 | Gynecol Oncol2009，113，2： | 1 |
| 12 | Cutting edge:interleukin 17 signals through a heteromeric receptor complex显示文摘 | Toy D Kugler D Wolfson M | | 0，，01： | 1 |
| 13 | Lyso- somal amino acid transporter SLC38A9 signals argi- nine sufficiency to mTORC1 显示文摘 | WANG S Y TSUN Z Y WOLFSON R L | 2015 | Science2015，347，6218： | 1 |
| 14 | Association of unmet need with selfrated health in a community dwelling cohort of disabled seniors 75 years of age and over显示文摘 | Quai J Addona V Wolfson C | 2007 | Eur J Ageing2007，4，1： | 1 |
| 15 | The relationship of knee and ankle weakness to falls in nursing home residents:an isokinetic study显示文摘 | Whipple Wolfson and Amerman | 1987 | J Am Geriatr Soc1987，35，1： | 1 |
| 16 | Testosterone,territoriality,and the ‘home advantage'显示文摘 | NEAVE N WOLFSON S | 2003 | Physiol Behav2003，78，： | 1 |
| 17 | Geometric hashing an overview 显示文摘 | Wolfson H J Rigoutsos I | 1997 | IEEE on Computational Science & Engineering1997，4，4： | 1 |
| 18 | Transient isolated lesion of the splenium associated with clinically mild influenza encephalitis显示文摘 | Ganapathy S Elizabeth HE Wolfson BJ | 2008 | Pediatr Radiol2008，38，11： | 1 |
| 19 | Geometric Hashing:An Overview显示文摘 | Wolfson H J Rigoutsos I | | 0，，04： | 1 |
| 20 | Burden of disease caused by Haemophilus influenzae type b in children younger than 5 years : glob- al estimates 显示文摘 | Watt JP Wolfson LJ O'Brlen KL | 2009 | Lancet2009，374，9693： | 1 |
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