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| 1 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 2 | Hardware-software co-design of embedded systems显示文摘 | Wolf W | 1994 | Proceedings of the IEEE1994，82，7： | 2 |
| 3 | Comparison of Intravitreal Bevacizumab versus Triamcinolone for the Treatment of Diffuse Diabetic Macular Edema显示文摘 | Kreutzer Thomas C Al Saeidi Rashid Kook Daniel Wolf Armin Ulbig Michael W Neubauer Aljoscha S Haritoglou Christos | 2010 | Ophthalmologica2010，，4： | 2 |
| 4 | Quantitative structure-activity relationships and mixture-toxicity studies of alcohols and chlorohydrocarbons: reproducibility of effects on growth and reproduction of Daphnia magna 显示文摘 | Wolf De W Canton J H Deneer J W | 1988 | Aquatic Toxicology1988，12，1： | 1 |
| 5 | The effect of melt composition on solidification cracking of steel, with particular reference to continuous casting显示文摘 | Wolf M Kurz W | 1982 | Metallurgical and Materials Transactions B1982，13，： | 1 |
| 6 | Ribosomal protein Lll negatively regulates oncoprotein MDM2 and mediates a p53- dependent ribosomal-stress checkpoint pathway 显示文摘 | Zhang Y 'Wolf G W Bhat K | 2003 | Mol Cell Biol2003，23，23： | 1 |
| 7 | Rates of nucleotide substitution vary greatly among plant mitochondrial,chloroplast and nuclear DNAs显示文摘 | WOLFE K H LI W H SHARP P M | 1987 | Proc Natl Acad Sci USA1987，84，5： | 1 |
| 8 | The repeatability of superovulatory response and embryo recovery in sheep显示文摘 | Bari F Khalid M Wolf B Haresigh W Murray A Merrell B | 2001 | Theriogenology2001，56，1： | 1 |
| 9 | Novel findings in gene expression deteeted in human osteosarcoma by cDNA microarray 显示文摘 | Wolf M El-Rifai W Tarkanen M | 2000 | Cancer Genet Cytogenet2000，123，2： | 1 |
| 10 | Internal fixation for intraarticulardistal radius fractures 显示文摘 | Barrie K A Wolfe S W | 2002 | Tech Hand Up Extren Surg2002，6，： | 1 |
| 11 | The protective role of sparse vegetation in wind erosion显示文摘 | Wolfe S A Nickling W G | 1993 | Progress on Physical Geography1993，17，： | 1 |
| 12 | Analysis of lateral DMOS power devices under ESD stress conditions显示文摘 | MERGENS M P J WILKENING W METTLER S WOLF H SRICKER A FICHTNER W | 2000 | IEEE Transactions on Electron Devices2000，47，11： | 1 |
| 13 | Implementation-efficient Reliability Ratio based Weighted Bit-flipping Decoding for LDPC Codes显示文摘 | Lee C H Wolf W | 2005 | Electronics Letters2005，41，13： | 1 |
| 14 | Warehouse location problem显示文摘 | Baumol W Wolfe P A | 1958 | Operation Research1958，6，2： | 1 |
| 15 | Hardware/software interface codesign for embedded systems显示文摘 | Jerraya A Wolf W | 2005 | IEEE Computer Society2005，38，2： | 1 |
| 16 | Growth hormone receptor is a target for presenilin-dependent gam- ma-secretase cleavage 显示文摘 | Cowan J W Wang X D Guan R He K Jiang J Baumann G Black R A Wolfe M S Frank S J | 2005 | J Biol Chem2005，280，19： | 1 |
| 17 | Purification and stability studies of the 11 S component of soybean proreins显示文摘 | Wolf W J Babcock G E Smith A K | 1962 | Arch Biochem Biophys1962，，99： | 1 |
| 18 | Prevalence, incidence,prognosis, and predisposing conditions for atrial fibrillation: population-based estimates显示文摘 | Kannel W B Wolf P A Benjamin E J | 1998 | Am J Cardiol1998，82，8： | 1 |
| 19 | An algorithm for stem detection using digital image analysis显示文摘 | Wolfe R R Sandler W E | 1985 | Trans of the ASAE1985，28，2： | 1 |
| 20 | Soybean protein aggregation by sonication: UUtraccntrifugal analysis显示文摘 | WANG L C WOLF W | 1983 | Food Sci1983，48，： | 1 |
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