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| 1 | In vivo and in vitro antiviral activity of hyperoside extracted from Abelmoschus manihot (L) medik显示文摘瞄准:为了估计反肝炎 B 病毒(HBV ) ,从 Abelmoschus manihot (L) medik.Methods hyperosideextracted 完成:人的 hepatoma Hep G2.2.15 房间 culturesystem 和鸭肝炎 B 病毒(DHBV ) 感染模型被用作在 vivo 并且在 vitro 模型 toevaluate anti-HBV effects.Results:在房间模型, hyperosidewas 的50%有毒的集中 0.115 g/L ;最大的无毒的集中是 0.05 g/L.On 最大的 nontoxicconcentrations ,在 2.2.15 个房间的 HBeAg 和 HBsAg 上的 hyperoside 的抑制率是 第86.41%a 82.27%在 d 上 8 , respectively.In DHBV 感染模型, DHBV-DNA 在中心点 kg-1centre 点 d-1 剂量 hyperoside 组织的 0.05 g 中心点 kg-1 中心点 d-1 和 0.10 g 的处理 decreasedsignificantly 铺平( P > 0.01 )山峰 o 的 .The 抑制这些结果建议 hyperoside 在感染 HBV 的鸭模型是在 2.2.15 个房间和 DHBV-DNA 层次的强壮的禁止者 ofHBsAg 和 HBeAg 分泌物。 | Lin-lin WO Xin-bo YANG Zheng-ming HUANG He-zhi LIU Guang-xia WO | 2007 | Acta Pharmacologica Sinica2007，28，3： | 33 |
| 2 | Livestock-carrying capacity and overgrazing status of alpine grassland in the Three-River Headwaters region, China显示文摘在中国的三河的 Headwaters 区域是为中流和下游的区域提供环境保护和地区性的持续开发的一个生态的障碍,它也在中国在畜牧起一个重要作用。这研究基于 MODIS NPP 数据在三河的 Headwaters 区域估计了草地收益,并且计算了草地的合适的带家畜的能力。我们通过在实际、合适的带家畜的能力之间的数据比较分析了过度放牧的数字和它的空间分发特征。结果显示出下列:(1 ) 在三河的 Headwaters 区域的全部的草地产量(干草) 与 465.70 kg/hm2 的平均草地收益是在 2010 的 1096 万吨(空间分发接着从东方和东南介绍一个减少的趋势给西方和西北) ;( 2 )在三河的 Headwaters 区域的合适的带家畜的能力是1219万个绵羊单位(此后描述了为苏),并且平均袜子能力是 51.27 苏[合适的带能力在在东方县的 100 SU/km2 上面,在中央县的 60 SU/km2 (除了 Madoi 县),并且在西方的县的 30 SU/km2 ];并且(3 ) 全部的过度放牧数字是在在 2010 的三河的 Headwaters 区域的 652 万苏,与过度放牧的一般水准, 67.88% 的比率和过度放牧的一般水准 27.43 SU/km2 数。更高的过度放牧比率发生在 Tongde, Xinghai, Yushu,河南省和 Z ? 甠据牥慴湩祴漠 ? 桴 ? 慣楬牢瑡潩 ? 敲?瑬 ? 慷 ? 癥污慵整 ? 祢瀠牥潦浲湩 ? 档牡吗?? | ZHANG Jiping | 2014 | Journal of Geographical Sciences2014，24，2： | 25 |
| 3 | 无创血流动力学监护系统在高危外科患者复苏治疗中的应用显示文摘目的 :探讨在急诊条件下早期应用无创血流动力学监护系统的必要性和可行性 ,评估其早期揭示循环功能不良和在早期高危急诊外科患者复苏治疗中的指导作用。方法 :用无创血流动力学监护系统监测 1 5 6例高危急诊外科患者 ,对其中 4 8例同时进行了有创血流动力学监护系统 (Swan Ganz法 )的观察 ,并将两种方法所得结果进行比较。结果 :无创血流动力学监护系统所获得的心排血量 (CO)和心脏指数 (CI)值与有创血流动力学监护系统所获得的值非常接近 ,在急诊条件下 ,r=0 .6 9,r2 =0 .87,P<0 .0 0 1 ;偏差和精确度为 (0 .6 2±0 .38) L· min- 1 · m- 2 。在 ICU条件下进一步比较两种方法所得结果 :r=0 .84 ,r2 =0 .93,P<0 .0 0 1 ;偏差和精确度为 (0 .36± 0 .1 5 ) L· m in- 1· m- 2。结论 :在急诊条件下应用无创血流动力学监护系统可显示创伤初期和复苏早期阶段的低血压、低 CI、低经皮氧张力 (Ptc O2 )、低血氧饱和度 (Sa O2 )和高经皮二氧化碳张力 (Ptc CO2 )的变化过程 ,并且为早期复苏治疗提供直观、可靠、连续性的依据 ,对预防由于长时间组织低血流量和低灌注所致的休克。 | 卢君强 李春盛 杨佳勇 Jay Zhu Charles Wo William C.Shoemaker | 2003 | 中国危重病急救医学2003，15，12： | 24 |
| 4 | Sleep-related hypoxemia aggravates systematic inflammation in emphysematous rats显示文摘背景睡觉骚乱在有肺气肿的病人是普通的。这研究试图带着老鼠在肺气肿( SRHIE )开发睡觉相关的血氧不足( SRH )的一个新奇模型,并且在肺探索 SRHIE 的煽动性的地位,肝,胰,七十五只男 Wistar 老鼠根据暴露条件每组与 15 被分到 5 个组的颈动脉动脉和整个 blood.Methods 。协议与组织缺氧暴露的度和肺气肿由香烟烟暴露引起了的先存在的严厉变化了:( 1 ) SRH 控制( SRHCtrl )组,假冒的烟暴露(烟暴露,暴露了每天 15 支香烟吸烟两次, 16 个星期)并且 SRH 暴露(12.5% O2 , 3 个小时, SRH 暴露,均匀地把全部的组织缺氧时间( 1.5 个小时或 3 个小时)划分成 4 个时期( 22.5 分钟或 45 分钟)并且均匀地散布这些组织缺氧时期直到脑电图识别的老鼠的生理的睡觉时间,到星期 16 的星期 9 );(2 ) 肺气肿控制(ECtrl ) 组,烟暴露和假冒的 SRH 暴露(21% O2, 3 个小时) ;(3 ) 在肺气肿(SRHShort ) 的短 SRH 组,烟暴露和短 SRH 暴露(12.5% O2, 1.5 个小时) ;(4 ) 在肺气肿(SRHMild ) 的温和 SRH 组,烟暴露和温和 SRH 暴露(15% O2, 3 个小时) ;(5 ) 在肺气肿(SRHStand ) 的标准 SRH 组,烟暴露和 SRH 暴露(12.5% O2, 3 个小时) 。ECtrl, SRHShort, SRHMild 和 SRHStand 组是有 emphysematous 老鼠的组。在暴露的结束前的二天,在每个组的 5 只老鼠随机为动脉的血气体分析被选择。在在各个的 10 只老鼠组织的剩余的,我们为平淡的测试获得了血样品和 bronchoalveolar lavage 液体(BALF ) 。我们也为病理学的得分和肝的大小获得了肺,肝,胰,和正确颈动脉动脉的织物块氧化应力(测量肝的氧化压力酶, superoxide dismutase (草皮)活动,过氧化氢酶(猫)活动和 malondialdehyde ( MDA )集中) .Results Emphysematous 组有更高的平均数线性拦截( MLI )并且吝啬的牙槽的数字(人)价值比 SRHCtrl 组。在 SRHStand 组的 MLI 价值是最高(生病 P 0.05 ) 。在 SRHStand 老鼠的 O2Sat SRH 暴露是什么时候(83.45 ? 韴 ?( | FENG Jing Ambrose An-Po Chiang WU Qi CHEN Bao-yuan CUI Lin-yang LIANG Dong-chun ZHANG Ze-li YAO Wo | 2010 | Chinese Medical Journal2010，，17： | 15 |
| 5 | Cyclooxygenase-2 and epithelial growth factor receptor up-regulation during progression of Barrett's esophagus to adenocarcinoma显示文摘瞄准:在整个 Barretts 食管的前进调查 cyclooxygenase-2 (COX-2 ) 和上皮的生长因素受体(EGFR ) 的表示() 。方法:COX-2 和 EGFR 蛋白质表情被使用免疫检测组织化学的方法。详细 cytomorphological 改变的 A 是坚定的。COX-2 和 EGFR 表示的区域被使用计算机成像系统确定。结果:COX-2 和 EGFR 的表情与前进一起增加了从到食管腺癌(EAC ) 。积极关联在 COX-2 表示和 EGFR 表示之间被发现。结论:COX-2 和 EGFR 可能在逐步的前进从是合作的到 EAC,从而导致致癌作用。 | Yan Li John M Wo Mukunda B Ray Whitney Jones Ruifeng R Su Susan Ellis Robert C G Martin | 2006 | World Journal of Gastroenterology2006，12，6： | 14 |
| 6 | Rapid Detection and Identification of Infectious Pathogens Based on High-throughput Sequencing显示文摘 | Pei-Xiang Ni Xin Ding Yin-Xin Zhang Xue Yao Rui-Xue Sun Peng Wang Yan-Ping Gong Jia-Li Zhou Dong-Fang Li Hong-Long WO Xin Yi Ling Yang Yun Long | 2015 | Chinese Medical Journal2015，，7： | 13 |
| 7 | CROWN:A service grid middleware with trust management mechanism显示文摘Based on a proposed Web service-based grid architecture, a service grid middleware system called CROWN is designed in this paper. As the two kernel points of the middleware, the overlay-based distributed grid resource management mechanism is proposed, and the policy-based distributed access control mechanism with the capability of automatic negotiation of the access control policy and trust management and negotia- tion is also discussed in this paper. Experience of CROWN testbed deployment and ap- plication development shows that the middleware can support the typical scenarios such as computing-intensive applications, data-intensive applications and mass information processing applications. | HUAI Jinpeng HU Chunming LI Jianxin SUN Hailong WO Tianyu | 2006 | Science in China(Series F)2006，49，6： | 8 |
| 8 | Decentralized robust guaranteed cost control for a class of interconnected singular large-scale systems with time-delay and parameter uncertainty显示文摘The decentralized robust guaranteed cost control problem is studied for a class of interconnected singular large-scale systems with time-delay and norm-bounded time-invariant parameter uncertainty under a given quadratic cost performance function. The problem that is addressed in this study is to design a decentralized robust guaranteed cost state feedback controller such that the closed-loop system is not only regular, impulse-free and stable, but also guarantees an adequate level of performance for all admissible uncertainties. A sufficient condition for the existence of the decentralized robust guaranteed cost state feedback controllers is proposed in terms of a linear matrix inequality (LMI) via LMI approach. When this condition is feasible, the desired state feedback decentralized robust guaranteed cost controller gain matrices can be obtained. Finally, an illustrative example is provided to demonstrate the effectiveness of the proposed approach. | Wo Songlin Shi Guodong Zou Yun | 2007 | Journal of Systems Engineering and Electronics2007，18，1： | 8 |
| 9 | Mutations in precore and core promoter region of HBV in patients with hepatic failure显示文摘Objective: To clarify the association of hepatitis Bvirus mutants in precore and core promoter regions inpatients with hepatic failure and HBeAg state.Methods: Precore and core promoter regions of 25HBV isolates from the patients with hepatic failurewere analyzed by polymerase chain reaction (PCR)direct sequencing approach.Results: Precore G-to-A1896 mutants were identified in16 (64%) of the 25 isolates. The 'hot spot' mutationsat A-to-T1762 and G-to-A1764 were present together in19 (76%) of the 25 isolates, while C-to-T1653 and T-to-C1753 existed in a mutually exclusive manner andmore frequently in hepatic failure with liver cirrhosisgroup than in hepatic failure with chronic hepatitisgroup (100% vs 50%). Both A1896 and T1762-A1764could be found frequently in HBeAg-positive subjects(77.8% and 88.9%), whereas T1653/C1753 was moreprevalent in anti-HBe-positive subjects than inHBeAg-positive subjects (93.8% vs 33.3%).Conclusions: The whole frequency of mutations in pre-core and core promoter gene will become more fre-quent as HBV infection is to be persistent. Mutationto T1653/C1753 may be useful as a marker for hepaticfailure. It requires further study whether the mixedinfection of mutants and wilds will develop and affectthe condition of HBeAg in serum along the progres-sion of liver disease. | Reinhard H. Dennin Jian-Er Wo | 2002 | Hepatobiliary & Pancreatic Diseases International2002，1，1： | 7 |
| 10 | Controls of Late Jurassic-Early Cretaceous tectonic event on source rocks and seals in marine sequences,South China显示文摘Thermal evolution of source rocks and dynamic sealing evolution of cap rocks are both subjected to tectonic evolution.The marine sequences in South China have experienced superposed structural deformation from multiple tectonic events.To investigate the effectiveness of preservation conditions,it is of great importance to understand the controls of key tectonic events on the dynamic evolution of cap rocks.This paper discusses the controls of Late Jurassic-Early Cretaceous(J3-K1) tectonic event on source and cap rocks in marine sequences in South China based on the relationships between J3-K1 tectonic event and the burial history types of the marine sequences,the hydrocarbon generation processes of marine source rocks,the sealing evolution of cap rocks,the preservation of hydrocarbon accumulations,and the destruction of paleo-oil pools.The study has the following findings.In the continuously subsiding and deeply buried areas during the J3-K1 period,marine source rocks had been generating hydrocarbons for over a long period of time and hydrocarbon generation ended relatively late.At the same time,the sealing capacity of the overburden cap rocks had been constantly strengthened so that hydrocarbons could be preserved.In the areas which suffered compressional deformation,folding and thrusting,uplifting and denudation in J3-K1,the burial history was characterized by an early uplifting and the hydrocarbon generation by marine source rocks ended(or suspended) during the J3-K1 period.The sealing capacity of the cap rocks was weakened or even vanished.Thus the conditions for preserving the hydrocarbon accumulations were destroyed.The continuously subsiding and deeply buried areas during the J3-K1 period are the strategic precincts of the petroleum exploration in marine sequences in South China. | JIN ZhiJun YUAN YuSong LIU QuanYou WO YuJin | 2013 | Science China Earth Sciences2013，56，2： | 6 |
| 11 | 材料杨氏模量的纳米压入识别显示文摘通过对非理想Berkovich压头压入弹塑性固体的加、卸载曲线所进行的近似解析分析和数值分析表明,在材料杨氏模量与压入参数间存在新的近似函数关系,该关系把名义硬度和综合杨氏模量的比值与卸载功和压入总功的比值联系起来.其中名义硬度Hn被定义为最大压入载荷Pm除以压头对应于最大压入深度hm时的横截面积A(hm),即Hn=Pm/A(hm).结果材料杨氏模量的识别可以通过仅仅测定压头的最大压入载荷、最大压入深度以及压入功来实现,而不必利用初始卸载斜率和投影接触面积.因此将该方法称为纯能量方法.经5种材料杨氏模量的纳米压入识别实验证明,纯能量方法较现有方法具有较高的识别精度. | 马德军 刘建敏 Chung Wo Ong 何家文 | 2004 | 中国科学(E辑)2004，34，5： | 6 |
| 12 | Abnormal Expression of Eukaryotic Translation Factors in Malignant Transformed Human Bronchial Epithelial Cells Induced by Crystalline Nickel Sulfide显示文摘Objective To study the oncogenic potential of mouse translation initiation factor 3 (TIF3) and elongation factor-1δ (TEF-1δ) in malignant transformed human bronchial epithelial cells induced by crystalline nickel sulfide (NiS). Methods Abnormal expressions of human TIF3 and TEF-1δ genes in two kinds of NiS-transformed cells and NiS-tumorigenic cell lines were investigated and analyzed by the reverse transcript polymerase chain reaction (RT-PCR) and fluorescent quantitative polymerase chain reaction (FQ-PCR), respectively. Results RT-PCR analysis primarily showed that both human TIF3 and TEF-1δ mRNA expressions in two kinds of NiS-transformed cells and NiS-tumorigenic cell lines were increased as compared with controls. FQ-PCR assay showed that the levels of TIF3 expressions in the transformed cells and tumorigenic cells were 3 and 4 times higher respectively, and the elevated expressions of TEF-1δ cDNA copies were 2.7- to 3.5-fold in transformed cells and 4.1- to 5.2-fold in tumorigenic cells when compared with non-transformed cells, indicating that the over-expressions of human TIF3 and TEF-1δ genes were related to malignant degree of the cells induced by nickel. Conclusions These findings demonstrate that there are markedly abnormal expressions of TIF3 and TEF-1δ genes during malignant transformation of human bronchial epithelial cell lines induced by crystalline NiS. They seem to be the molecular mechanisms potentially responsible for human carcinogensis due to nickel. | YI-XIONG LEI XUE-MIN CHEN GEN-RONG WO JIA-KUN CHEN | 2006 | Biomedical and Environmental Sciences2006，19，1： | 5 |
| 13 | In vitro cleavage of hepatitis B virus C mRNA by 10-23 DNA enzyme显示文摘BACKGROUND: 10-23 DNA enzyme is one kind of de-oxyribozymes for RNA cleavage. The inhibition effects of 10-23 DNA enzyme on the expression of the HBV C gene in HepG2. 2. 15 cells were demonstrated previously. The aim of this study was to further explore the cleavage activities of 10-23 DNA enzyme targeting at HBV C gene mRNA in vitro. METHODS: 10-23 DNA enzyme named Drz-HBV-C-9 specific to HBV C gene ORF A1816UG was designed and synthesized. HBV C gene mRNA was obtained by the in vitro transcription method. Cleavage activities of Drz-HBV-C-9 were observed in vitro. Values of kinetic parameters including Km,Kcat and Kcat/Km were calculated accordingly. RESULTS: Under the certain cleavage conditions, Drz-HBV-C-9 could efficiently cleave target mRNA at specific sites in vitro. Cleavage products of 109nt plus 191nt were obtained. The kinetic parameters, Km,Kcat and Kcat/ Km for Drz-HBV-C-9, were 1.4 ×10-9 mol, 1.6 min-1 and 1.1 × 109 mol-1 · min-1, respectively. CONCLUSIONS: 10-23 DNA enzyme targeting at HBV C gene mRNA possesses specific cleavage activities in vitro. This would be a potent antiviral strategy with respect to HBV gene therapy. | Wei Hou, Jian-Er Wo, Min-Wei Li and Ke-Zhou Liu Institute of Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，4： | 5 |
| 14 | Study on a 5.0 W/80 K single stage Stirling type pulse tube cryocooler显示文摘A single stage Stirling pulse tube cryocooler was designed based on REGEN 3.2 and fabricated for testing. The experimental results show that the cooler can provide a cooling capacity of 5.0 W at 79.1 K, and produce a no-load temperature of 57.0 K, operating with an average pressure of 2.50 MPa and a frequency of 60 Hz, performance results that are very close to the calculated values. The cryocooler can be cooled from room temperature to 80 K in 8.5 min. The fast cooldown time is a result of the small regenerator. | Zhi-hua GAN Guo-jun LIU Ying-zhe WO Qiang CAO Li-min QIU Guo-bang CHEN J.M. PFOTENHAUER | 2008 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2008，9，9： | 5 |
| 15 | Identification and Characterization of Tumorigenic Liver Cancer Stem/Progenitor Cells显示文摘 | Stephanie Ma Kwok–Wah Chan Liang Hu Terence Kin–Wah Lee Jana Yim–Hung Wo Irene Oi–Lin Ng Bo–Jian Zheng Xin–Yuan Guan | 2007 | Gastroenterology2007，，7： | 4 |
| 16 | Effect of IFNα-2a on Fas expression and apoptosis rate of peripheral blood cytotoxic T cells in patients with hepatitis B显示文摘Interferon(IFN) with antiviral and im-munomodulatory activities is one of the most important therapeutic agents for the treatment of chronic hepatitis. The apoptotic effect of IFN is influenced by cell type and the types of IFN, which suppresses proliferation and induces apoptosis in some cell types while inhibiting apoptosis in others. The aim of this study was to explore the effect of IFNα-2a on Fas expression and the apoptosis rate of peripheral blood cytotoxic T cells (CTLs) in patients with hepatitis B. METHODS:Peripheral blood mononuclear cells were isolated from 26 patients with hepatitis B including 16 patients with chronic hepatitis B and 10 patients with chronic severe hepatitis B. Fas expression and apoptosis rate of CTLs were analyzed with flow cytometry before and after IFNα-2a treatment. RESULTS:Before IFNα-2a treatment, Fas expression and apoptosis rate of CTLs from patients with chronic hepatitis B were significantly higher than those from patients with chronic severe hepatitis B and healthy controls respectively. No significant difference was observed between Fas expression and apoptosis rate of CTLs from patients with chronic severe hepatitis B and healthy controls. After IFNα-2a treatment,Fas expression and apoptosis rate of CTLs from different groups were compared with those before IFNα-2a treatment, showing no significant difference despite alternation of different degree. CONCLUSIONS:Activation induced cell death (AICD) exists in peripheral blood CTLs from patients with hepatitis B. No effect of IFNα-2a exerts on Fas expression and apoptosis rate of Fas in patients with hepatitis B. | Institute of Infectious Diseases, Zhejiang University School of Medicine, Hangzhou 310003, China (Hou W, Liu KZ, Li MW and Wo JE) | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 4 |
| 17 | Decentralized H-infinity state feedback control for discrete-time singular large-scale systems显示文摘The decentralized H-infinity control problem for discrete-time singular large-scale systems is considered. Based on the bounded real lemma of discrete-time singular systems, a sufficient condition for the existence of decentralized H-infinity controller for discrete-time singular large-scale systems is presented in terms of the solvability to a certain system of linear matrix inequalities by linear matrix inequality (LMI) approach, and the feasible solutions to the system of LMIs provide a parameterized representation of a set of decentralized H-infinity controller. The given example shows the application of the method. | Songlin WO 1 , Yun ZOU 2 , Shengyuan XU 2 (1.School of Electrical and Information Engineering, Jiangsu Teachers University of Technology, Changzhou Jiangsu 213001, China 2.School of Automation, Nanjing University of Science and Technology, Nanjing Jiangsu 210094, China) | 2010 | 控制理论与应用(英文版)2010，8，2： | 3 |
| 18 | Methodology of the Global Adult Tobacco Survey in China, 2010显示文摘INTRODUCTION The Global Adult Tobacco Survey (GATS) is a component of Global Tobacco Surveillance System (GTSS) under auspices of the Bloomberg philanthropy and the Bill and Melinda Gates Foundation. | JASON HSIA GONG-HUAN YANG QIANG LI LIN XIAO VAN YANG YAN-WEI WO SAMIRAASMA | 2010 | Biomedical and Environmental Sciences2010，23，6： | 3 |
| 19 | Downregulated cytotoxic CD8^(+)T-cell identifies with the NKG2A-soluble HLA-E axis as a predictive biomarker and potential therapeutic target in keloids显示文摘Keloids are an abnormal fibroproliferative wound-healing disease with a poorly understood pathogenesis,making it difficult to predict and prevent this disease in clinical settings.Identifying disease-specific signatures at the molecular and cellular levels in both the blood circulation and primary lesions is urgently needed to develop novel biomarkers for risk assessment and therapeutic targets for recurrence-free treatment.There is mounting evidence of immune cell dysregulation in keloid scarring.In this study,we aimed to profile keloid scar tissues and blood cells and found that downregulation of cytotoxic CD8^(+)T cells is a keloid signature in the peripheral blood and keloid lesions.Single-cell RNA sequencing revealed that the NKG2A/CD94 complex was specifically upregulated,which might contribute to the significant reduction in CTLs within the scar tissue boundary.In addition,the NKG2A/CD94 complex was associated with high serum levels of soluble human leukocyte antigen-E(sHLA-E).We subsequently measured sHLA-E in our hospital-based study cohort,consisting of 104 keloid patients,512 healthy donors,and 100 patients with an interfering disease.The sensitivity and specificity of sHLA-E were 83.69%(87/104)and 92.16%(564/612),respectively,and hypertrophic scars and other unrelated diseases exhibited minimal interference with the test results.Furthermore,intralesional therapy with triamcinolone combined with 5-fluorouracil drastically decreased the sHLA-E levels in keloid patients with better prognostic outcomes,while an incomplete reduction in the sHLA-E levels in patient serum was associated with higher recurrence.sHLA-E may effectively serve as a diagnostic marker for assessing the risk of keloid formation and a prognostic marker for the clinical outcomes of intralesional treatment. | Heng Xu Zhu Zhu Jian Hu Jiawei Sun Yan Wo Xianshu Wang Hongzhi Zou Bin Li Yixin Zhang | 2022 | Cellular & Molecular Immunology2022，19，4： | 3 |
| 20 | MDM2 SNP309 contributes to tumor susceptibility:A meta-analysis显示文摘潜在地功能的多型性, SNP309,在 MDM2 的倡导者区域,基因在出版研究看了不确定的结果的癌症风险,而是个人被含有。获得在 MDM2 SNP309 和癌症的风险之间的协会的更精确的估计,我们在与肿瘤和 33,046 控制的不同类型包括了 26,160 个盒子的 59 份出版物执行了 70 单个研究的元分析。概括机会比率(或) 并且相应当适当时, 95% 信心间隔(CI ) 用改正效果和随机效果的模型被估计。总的来说,变体遗传型在不同基因模型为所有癌症类型与显著地增加的癌症风险被联系(GG 对 TT:或, 1.123;95% CI, 1.0561.193;GG/GT 对 TT:或, 1.028;95% CI, 1.0061.050 ) 。在成层的分析,为大多数的研究仍然是的增加的风险癌症,亚洲人口,和医院打字 -- 在不同基因模型的 /population-based 研究,而显著地减少了,风险在前列腺癌症被发现(GG 对 TT:或, 0.606;95% CI, 0.4070.903;GG/GT 对 TT:或, 0.748;95% CI, 0.5790.968 ) 。在结论,元分析的数据建议 MDM2 SNP309 是为癌症风险的潜在的 biomarker。 | Xiaoman Wo Dong Han Haiming Sun Yang Liu Xiangning Meng Jing Bai Feng Chen Yang Yu Yan Jin Songbin Fu | 2011 | Journal of Genetics and Genomics2011，38，8： | 3 |
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