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| 1 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 2 | 重组卡介苗表达的MalE蛋白T细胞表位的鉴定显示文摘目的 鉴定重组卡介苗表达的MalE蛋白T细胞表位。方法 用抗原提呈试验、T细胞增殖试验、ELISPOT试验和表位作图测试重组MalE蛋白的T细胞表位。结果 重组BCG MalE功能性表达了MalE蛋白的 4种H 2 d 限制性T细胞表位。结论 在 4种表位中 ,p6 8~ 82是重组MalE蛋白的主要T细胞表位 ,而其余 | 焦新安 Richard Lo-man Edith Driaud Sophie Burgaud Brigitte Gicquel Nathalie Winter Claude Leclerc 刘秀梵 | 2002 | 中华微生物学和免疫学杂志2002，22，1： | 3 |
| 3 | 重组卡介苗感染树突细胞的研究显示文摘在体内外试验中 ,树突细胞 (DC)均能摄取表达大肠杆菌麦芽糖结合蛋白 (MalE)的重组卡介苗 (rBCG·MalE)。应用流式细胞术测得荧光标记的rBCG·MalE在体内感染DC的水平在 1 % 2 % ,与感染巨噬细胞 (MΦ)的水平相当。体外抗原提呈试验结果显示 ,DC和MΦ能吞噬、加工rBCG·MalE并向T细胞杂交瘤FBU·B1 1提呈MalE蛋白抗原表位 ,而在体内试验中 ,从rBCG·MalE免疫小鼠脾脏中纯化的DC ,可检测到MalE表位MHCⅡ复合物 ,而纯化的MΦs却测不到。这表明DC在起始抗分枝杆菌的免疫保护中发挥关键作用。 | 焦新安 Richard Lo-Man Pierre Guermonprez Edith Dériaud Brigitte Gicquel Nathalie Winter Claude Leclerc 刘秀梵 | 2002 | 扬州大学学报(农业与生命科学版)2002，23，1： | 2 |
| 4 | Soil microarthropods in longterm no-tillage and conventional corn production显示文摘 | Winter J P Voroney R P Ainsworth D A | 1990 | Canadian Journal of Soil Science1990，70，： | 1 |
| 5 | Three-dimensional wave instability near a critical layer显示文摘 | Winters K B D' asaro E A | 1994 | Joumal of Fluid Mechanics1994，272，： | 1 |
| 6 | Quality-of-life assessment of pa-tients after ileal pouch-anal anastomosis for slow-transit constipation withrectal inertia显示文摘 | Kalbassi MR Winter DC D^asyJM | 2003 | Dis Colon Rectum2003，46，11： | 1 |
| 7 | Kinetic analysis of the lower limbsduring walking:What information can be gained from athree-dimensional model显示文摘 | Eng J J Winter D A | 1995 | Biomech1995，28，6： | 1 |
| 8 | Thrombomodulin expression in colorectal carcinoma is protective and correlates with survival显示文摘 | HANLY A M REDMOND M WINTER D C | 2006 | Br J Cancer2006，94，9： | 1 |
| 9 | Respiratory syncytial virus infectionand G and/or SH protein expression contribute to substance P,which mediates inflammation and enhanced pulmonary disease in Balb/c mice显示文摘 | Tripp RA Moore D Winter J | 2000 | J Virol2000，74，： | 1 |
| 10 | Molecular identification of a volume regulated chloride channel显示文摘 | Duan D Winter C Cowley S | 1997 | Nature1997，390，： | 1 |
| 11 | Management of severe spondylolisthesis in children and adolescents 显示文摘 | Boxall D Bradford DS Winter RB | 1979 | Bone Joint surg Am1979，61，： | 1 |
| 12 | A simplified tumor re- gression grade correlates with survival in locally advanced rectal carcinoma treated with neoadjuvant chemoradiotherapy显示文摘 | Beddy D Hyland JM Winter DC | 2008 | Ann Surg Oncol2008，15，： | 1 |
| 13 | The valueof auditor assurance:Evidence from loan pricing 显示文摘 | Blackwell D W Noland T R Winter D B | 1998 | Journal ofAccounting Research1998，36，01： | 1 |
| 14 | An 'electronic fluorescent pictograph' browser for exploring and analyzing large-scale biological data sets显示文摘 | Winter D Vinegar B Nahal H Ammar R Wilson GV Provart N J | 2007 | PLoS One2007，2，8： | 1 |
| 15 | Modern triage in the e- mergency department显示文摘 | Christ M Grossmann F Winter D et ul | 2010 | Dtsch Arztebl Int2010，107，50： | 1 |
| 16 | Lung Injury in Acute Pancreatitis: Mechanisms, Prevention, and Therapy显示文摘 | Shields C J Winter D C Redmond H P | 2002 | Curr Opin Crit Care2002，8，2： | 1 |
| 17 | Methane gas hydrate effect on sediment acoustic and strength properties显示文摘 | Winters W J Waite W F Mason D H | 2007 | Journal of Petroleum Science and Engineering2007，56，： | 1 |
| 18 | Photochemical generation of nitrenium ions from protonated 1,1- diarylhydrazines 显示文摘 | Winter A H Thomas S L Falvey D E | 2004 | Org Lett2004，6，25： | 1 |
| 19 | Is human fracture hematoma inherently angiogenic?显示文摘 | Street J Winter D Wang JH | 2000 | Clin Orthop2000，，378： | 1 |
| 20 | The impact of antenna diversity on the capacity of wireless cormmunication systern显示文摘 | Winters J H Salz J Gitlin R D | 1994 | IEEE Trons Commun1994，42，234： | 1 |
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