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| 1 | Gut microbiome in primary sclerosing cholangitis:A review显示文摘Primary sclerosing cholangitis(PSC)is a chronic cholestatic liver disease characterized by biliary inflammation and stricturing.Exploration of the pathogenesis of PSC in light of its association with inflammatory bowel disease(IBD)and the“gut-liver”axis is an emerging area of interest.A growing number of studies have begun to elucidate the role of the gut microbiota,its metabolites and its influence on host immune responses in the development of PSC and PSCIBD.Studies of the fecal microbiota have highlighted enriched levels of certain species,including Veillonella,Streptococcus and Enterococcus,among others.A heightened immune response to enteric dysbiosis and bacterial translocation have also been implicated.For example,Klebsiella pneumoniae strains derived from gnotobiotic mice transplanted with PSC-IBD microbiota were found to induce pore formation in human intestinal epithelial cells and enhanced Th17 responses.Gut microbes have additionally been hypothesized to be implicated in PSC pathogenesis through their role in the synthesis of various metabolites,including bile acids(BAs),which function as signaling molecules with important gut and hepatic effects.An expanded knowledge of the gut microbiome as it relates to PSC offers critical insight into the development of microbe-altering therapeutic interventions,such as antibiotics,nutritional interventions and fecal microbial transplantation.Some of these have already shown some preliminary evidence of benefit.Despite exciting progress in the field,much work remains to be done;areas that are particularly lacking include functional characterization of the microbiome and examination of pediatric populations.In this review,we summarize studies that have investigated the microbiome in PSC and PSC-IBD as well as putative mechanisms,including the potential role of metabolites,such as BAs.We then briefly review the evidence for interventions with microbe-altering properties for treating PSC. | Rebecca Little Eytan Wine Binita M Kamath Anne M Griffiths Amanda Ricciuto | 2020 | World Journal of Gastroenterology2020，26，21： | 5 |
| 2 | CH3SH photolysis at 248nm,hydrogen atom yield and rate constant for the H+CH3SH reaction 显示文摘 | WINE P H NICOVICH J M HYNES A J | 1986 | J Phys Chem1986，90，17： | 2 |
| 3 | CFTR activation raises extracellular pH of NIH/3T3 mouse fibroblasts and C127 epithelial cells显示文摘 | Luckie D B Singh C N Wine J J | 2001 | J Membr Biol2001，179，3： | 2 |
| 4 | 单细胞蛋白的研究 Ⅱ.利用酒糟生产酵母蛋白饲料显示文摘试验于1985~1987年进行,本研究课题选育的117号和136号酵母诱变株生产的酒糟酵母蛋白饲料含蛋白质28.18%,且具备牲畜必需的10种氨基酸,经高温40℃驯化的酵母菌,回复到适温28℃培养,酵母细胞增殖率明显提高,采用混合菌比单一菌生产酒糟酵母蛋白饲料,蛋白质含量增加,在发酵浪中加入糖化酶,蛋白质含量相应增加,沉淀过滤速度显著加快,酒糟酵母蛋白饲料饲养牲猪,与鱼粉对比差异显著(p>0.05) | Section of Microbiology,Hunan Agricultural College Liuyang Wine Factory | 1989 | 湖南农学院学报1989，15，1： | 2 |
| 5 | Augmened vasoconstrictor response to serotonin precede development of artherosclerosis in aorta of WHHL rabbit显示文摘 | WINES P A SCHMITZ J M PFISTER S L | 1989 | Atheriosclerosis1989，9，2： | 1 |
| 6 | Comprehensive mutation screening in a cystic fibrosis center 显示文摘 | Kuo E Hurlock G | 2001 | Pediatrics2001，107，2： | 1 |
| 7 | In vivo molecular imaging of acute and subacute thrombosis using a fibrin-binding magnetic resonance imaging contrast agent显示文摘 | Botnar RM Perez AS Wine S et a1 | 2004 | Circulation2004，109，3： | 1 |
| 8 | The mechanism underlying defective Fcgamma receptor-mediated phagocytosis by HIV-1-infected human monocyte-derived macrophages显示文摘 | LEEANSYAH E WINES B D CROWE S M | | 0，，02： | 1 |
| 9 | Atopic dermatitis: review of im- munopathogenesis and advances in immunosuppressive therapy显示文摘 | Meagher L I Wines NY Cooper AJ | 2002 | Australas J Dermato12002，43，4： | 1 |
| 10 | Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro显示文摘 | Wine J Jung C K Shackel I | 1999 | Anal Biochem1999，270，1： | 1 |
| 11 | IGF-1 and p- AKT signaling promote hippocampal CA1 neuronal survival following injury to dentate granule cells 显示文摘 | Wine R N McPherson C A Harry G J | 2009 | Neurotoxicity Research2009，16，3： | 1 |
| 12 | Computed tomography measurement of the accuracy of component version in total hip arthroplasty显示文摘 | Wines AP McNicol D | 2006 | J Arthroplasty2006，5，： | 1 |
| 13 | Atopic dermatitis review of immuno- pathogenesis and advances in immunosuppressive therpy 显示文摘 | MeagherLJ Wines NY Cooper AJ | 2002 | Australas J Demato12002，43，4： | 1 |
| 14 | Cone beam computed tomography evaluationof changes in the nasmaxillary complex associated with two types of maxil- lary expanders显示文摘 | Pangrazio-Kulbersh V Wine P Haughey M | 2012 | Angle Orthod2012，82，3： | 1 |
| 15 | Atopic dermatitis: review of immunopathogenesis and advances in immunnsuppressive therapy 显示文摘 | Meagher LJ Wines NY Cooper AJ | 2002 | Australas J Dermatol2002，43，： | 1 |
| 16 | Analysis of meal patterns with the use of supervised data mining techniques-artificial neural networks and decision trees显示文摘 | Wine P Hearty Michael J Gibney | 2008 | Am J Clinical Nutrition2008，88，6： | 1 |
| 17 | Modification of protein crystal packing by systematic mutations of surface residues:Implications on biotemplating and crysta l porosity显示文摘 | Wine Y Cohen-Hadar N Lamed R | 2009 | Biotech Bioeng2009，104，3： | 1 |
| 18 | Test Anxiety and Direction of Attention显示文摘 | WINE J | 1971 | Psy Bulletin1971，76，： | 1 |
| 19 | Determination of lignin and cellulose in acid detergent fiber with permanganate 显示文摘 | Van Soest P J Wine R H | 1968 | J Assoc Off Anal Chem1968，51，： | 1 |
| 20 | Managing the nem'opsychialricside effects of interferon-based therapy for hepatitis C显示文摘 | Crone CC Crabriel GM Wine TN | 2004 | Cleve Clin J Med2004，71，3： | 1 |
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