|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Alcoholic pancreatitis:New insights into the pathogenesisand treatment显示文摘Acute pancreatitis is a necro-inflammatory disease of the exocrine pancreas that is characterized by inappropriate activation of zymogens, infiltration of the pancreas by inflammatory cells, and destruction of the pancreatic exocrine cells. Acute pancreatitis can progress to a severe life-threatening disease. Currently there is no pharmacotherapy to prevent or treat acute pancreatitis. One of the more common factors associated with acute pancreatitis is alcohol abuse. Although commonly associated with pancreatitis alcohol alone is unable to cause pancreatitis. Instead, it appears that alcohol and its metabolic by-products predispose the pancreas to damage from agents that normally do not cause pancreatitis, or to more severe disease from agents that normally cause mild pancreatic damage. Over the last 10 to 20 years, a tremendous amount of work has defined a number of alcohol-mediated biochemical changes in pancreatic cells. Among these changes are: Sustained levels of intracellular calcium, activation of the mitochondrial permeability transition pore, endoplasmic reticulum stress, impairment in autophagy, alteration in the activity of transcriptional activators, and colocalization of lysosomal and pancreatic digestive enzymes. Elucidation of these changes has led to a deeper understanding of the mechanisms by which ethanol predisposes acinar cells to damage. This greater understanding has revealed a number of promising targets for therapeutic intervention. It is hoped that further investigation of these targets will lead to the development of pharmacotherapy that is effective in treating and preventing the progression of acute pancreatitis. | Dahn L Clemens Katrina J Schneider Christopher K Arkfeld Jaclyn R Grode Mark A Wells Shailender Singh | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 10 |
| 2 | Considerations for measuring ground CO2 effluxes with chambers显示文摘 | Welles J M Demetriades-Shah T H MeDermitt D K | 2001 | Chemical Geology2001，177，： | 1 |
| 3 | Evaluation of time- temperature related quality changes in icecream during storage 显示文摘 | DOLAN K D SINGH R P WELLS J H | 1985 | Journal of Food Processing and Preservation1985，9，： | 1 |
| 4 | Calculating controller area network (CAN) message response times显示文摘 | Tindell K Bums A Wellings A J | 1995 | Control Engineering Practice1995，3，8： | 1 |
| 5 | Comparative finite element analysis of the stress-strain states in three different bonded solid oxide fuel cell seal designs显示文摘 | Well K S Koeppel B J | 2008 | Joumal of Power Sources2008，180，1： | 1 |
| 6 | New empirical relationships among magnitude,rupture length,rupture width,rapture area,and surface displacement显示文摘 | WELLS D L COPPERSMITH K J | | 0，，04： | 1 |
| 7 | Polymyxin B and doxycycline use in patients with multidrug-resistant Acinetobacter baumannii infections in the intensive care unit显示文摘 | Holloway K P Rouphael N G Wells J B | 2006 | Ann Pharrnacother2006，40，11： | 1 |
| 8 | The Interaction of a Humic Acid with Heavy Metals显示文摘 | Spark K M Wells J D Johnson B B | 1997 | Austrlian Journey of Soil Research1997，35，1： | 1 |
| 9 | Estimating nuclear DNAcontent in peach and related diploid species using laser flow cytome-try and DNA hybridization显示文摘 | BAIRD W V ESTAGER A S WELLS J K | 1994 | Journal of the American Society forHorticultural Science1994，119，6： | 1 |
| 10 | Tallow aleohol sultates, properties in relation to chemical modification 显示文摘 | well J K Stirton A J Bistlire R G | 1959 | JAOCS1959，36，6： | 1 |
| 11 | Rotation of 3D Volumes by Fourier-interpolated Shears显示文摘 | Welling J S Eddy W F Young T K | 2006 | Graphical Models2006，68，4： | 1 |
| 12 | 显示文摘 | Well K S Hardy J S Rice J P | 2006 | Fuel2006，85，： | 1 |
| 13 | Sorption of heavy metals by mineral-humic acid substrates显示文摘 | Spark K M Wells J D Johnson B B | 1997 | Aust J Soil Res1997，35，： | 1 |
| 14 | Sorption of heavy metals by mineral-humic acid and substances显示文摘 | Spark K M Wells J D Johnson B B | 1997 | Soil Res1997，35，： | 1 |
| 15 | New empirical relationships among magnitude, rupture length, rup ture width, rupture area, and surface displacement显示文摘 | Wells D L Coppersmith K J | 1995 | Bull Seismol Soc Am1995，84，4： | 1 |
| 16 | Physical properties of blends of soap and lime soap dispersants 显示文摘 | WElL J K LINFIELD W M | 1979 | Journal of the American Oil Chemists'' Society1979，56，2： | 1 |
| 17 | Calculating controller area network (CAN) message response times显示文摘 | TINDELL K BURNS A WELLINGS A J | 1995 | Control Engi- neering Practice1995，3，8： | 1 |
| 18 | Clinical utilisation of a rapid low-pass whole genome sequencing technique for the diagnosis of aneuploidy in human embryos prior to implantation显示文摘 | Wells D Kaur K Grifo J | 2014 | J Meal Genet2014，51，8： | 1 |
| 19 | The distribution of colloidal and particulate bioactive metals in Narragansett Bay, RI显示文摘 | Smith G J Bruland K W | 2000 | Marine Chemistry2000，71，： | 1 |
| 20 | Calculating controller area network (CAN) message response times 显示文摘 | Tindell K Burns A Wellings A J | 1995 | Software Engineering Journal1995，21，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员