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| 1 | Computed tomography overestimation of esophageal tumor length: Implications for radiotherapy planning显示文摘AIM:To assess the relationship between preoperative computed tomography(CT)and postoperative pathological measurements of esophageal tumor length and the prognostic significance of CT tumor length data.METHODS:A retrospective study was carried out in 56 patients who underwent curative esophagogastrectomy.Tumor lengths were measured on the immediate preoperative CT and on the post-operative resection specimens.Inter-and intra-observer variations in CT measurements were assessed.Survival data were collected.RESULTS:There was a weak correlation between CT and pathological tumor length(r=0.30,P=0.025).CT lengths were longer than pathological lengths in 68%(38/56)of patients with a mean difference of 1.67 cm(95%CI:1.18-2.97).The mean difference in measurements by two radiologists was 0.39 cm(95% CI:-0.59-1.44).The mean difference between repeat CT measured tumor length(intra-observer variation) were 0.04 cm(95%CI:-0.59-0.66)and 0.47 cm (95%CI:-0.53-1.47).When stratified,patients not receiving neoadjuvant chemotherapy showed a strong correlation between CT and pathological tumor length(r =0.69,P=0.0014,n=37)than patients that did(r= 0.13,P=0.43,n=19).Median survival with CT tumor length>5.6 cm was poorer than with smaller tumors,but the difference was not statistically significant.CONCLUSION:Esophageal tumor length assessed using CT does not reflect pathological tumor extent and should not be the only modality used for management decisions,particularly for planning radiotherapy. | Karim Sillah Luke R Williams Hans-Ulrich Laasch Azeem Saleem Gillian Watkins Susan A Pritchard Patricia M Price Catharine M West Ian M Welch | 2010 | World Journal of Gastrointestinal Oncology2010，2，4： | 10 |
| 2 | Heme in intestinal epithelial cell turnover, differentiation, detoxification, inflammation, carcinogenesis, absorption and motility显示文摘胃肠道被经历包含两极分裂,区别和细胞死亡的经常的更新的一张单层上皮衬里。另外,上皮的衬里分开由保护上皮免受被突破的伤害的防御机制从内部周围的无菌的环境发生在肠的腔的消化和吸收的敌对过程。对这些防御过程中央是合成他我和它的分解代谢由他我氧合酶(惊讶) 。饮食他我也是为被收起的身体的铁的重要来源由 enterocyte 未经触动。这评论在肠道在 heme/HO 的多样的性质上描述最近的文学。在房间 cycle/apoptosis, xenobiotics 的 detoxification,氧化压力,发炎,结肠癌的发展, heme 铁吸收和肠的活动性的规定的 heme/HO 的角色明确地被检验。 | Phillip S Oates Adrian R West | 2006 | World Journal of Gastroenterology2006，12，27： | 8 |
| 3 | Mechanisms of heme iron absorption:Current questions and controversies显示文摘Iron is a critical micronutrient, and iron derived from heme contributes a large proportion of the total iron absorbed in a typical Western diet. Heme iron is absorbed by different mechanisms than non-heme iron, but despite considerable study over many years these mechanisms remain poorly understood. This review provides an overview of the importance of heme iron in the diet and discusses the two prevailing hypotheses of heme absorption; namely receptor mediated endocytosis of heme, and direct transport into the intestinal enterocyte by recently discovered heme transporters. A specific emphasis is placed on the questions surrounding the site of heme catabolism and the identity of the enzyme that performs this task. Additionally, we present the hypothesis that a non-heme iron transport protein may be required for heme iron absorption and discuss the experiences of our laboratory in examining this hypothesis. | Adrian R West Phillip S Oates | 2008 | World Journal of Gastroenterology2008，14，26： | 5 |
| 4 | 系统性药物治疗儿童银屑病的安全性显示文摘银屑病是一种常见的慢性炎症性皮肤病。成年人的发病率为2%~3%,其中大约有三分之一的患者在18岁之前发病。在儿童期,该病的发病率呈线性增长。从1970年至2000年,儿童银屑病的发病率增加了一倍多。尽管对许多轻度银屑病患儿而言,局部治疗已足够,但对更多可能影响生活质量的重度或顽固性的银屑病患儿,则往往需要系统性治疗。 | bronckers imgj seyger mmb west dp lara-corrales i tollefson m tom wl hogeling m belazarian l zachariae c mahé e siegfried e philipp s szalai z vleugels ra holland k murphy r baselga e cordoro k lambert j alexopoulos a mrowietz u kievit w paller as 邓婕(编译) 张锡宝(审校) 无 | 2017 | 皮肤性病诊疗学杂志2017，24，5： | 3 |
| 5 | Venous thromboembolism during active disease and remission in inflammatory bowel disease: a cohort study显示文摘 | Matthew J Grainge Joe West Timothy R Card | 2010 | The Lancet2010，，9715： | 3 |
| 6 | Magnetic resonance imaging of hepatocellular carcinoma induced by diethylnitrosamine in Sprague-Dawley rats显示文摘Diethylnitrosamine (DENA) is able to induce various benign and malignant liver lesions in rats with a high success rate and a low mortality rate. It provides a more appropriate model that better simulates the various lesions occurring in humans than the usual model of tumor implantations. The aim of the present study was to evaluate MRI liver examination in Sprague-Dawley(SD) rats as a routine method to detect hepatocellular carcinoma (HCC) nodules induced by DENA and to follow up their growth. METHODS:Hepatic carcinogenesis was induced in 80 male SD rats using oral DENA solution. All animals were imaged for liver tumor detection with a 1.5 Tesla magnet (Siemens Sonata,Erlangen, Germany) using correspondence scan parameters and a radio-frequency knee coil. Macroscopic examinations were performed along the axial MRI sections to evaluate magnetic resonance imaging (MRI) findings, and histopathological assessment was also performed. RESULTS:No false negative results were obtained on MR images. Hepatic tumors in 72 rats were confirmed macro-scopically and 68 rats were detected by MRI till the 20th week. The smallest and the largest nodules detected by MRI were 2 mm and 37 mm in diameter respectively. The agreement rate of MRI with macroscopic observation was 39. 1% and 97. 4% respectively for 2 mm to 5 mm and more than 5 mm nodules. CONCLUSIONS:The hepatic tumor induced by DENA provides a more representative range of tumors for imaging diagnosis and interventional treatment. MRI is the best approach for scrutinizing pathological changes of rat livers in the period of observation. | Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China (Li X, Zhou XP and Guan YS) Department of Radiology, Ruijin Hospieal. Shanghai Second Medical University, Shanghai 200025 , China. Current address:Astra Zeneca R & D Alderley, Macclesfield SK 10 4 TG U. K. (Wang YX) | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 3 |
| 7 | Why evidence for the fetal origins of adult disease might be a statistical artifact: the ' reversal paradox' for the relation between birth weight and blood pressure in later life 显示文摘 | Tu YK West R Ellison GT | 2005 | AmJ Epidemiol2005，161，1： | 1 |
| 8 | Elicitation of lignin biosynthesis and iso peroxidase activity by pectic fragnents insuspension cultures caster bean显示文摘 | Bruce R J West C A | 1989 | PlantPhysiol1989，91，： | 1 |
| 9 | Supplemental vitamin h enhances the recovery from iron deficiency inrates with chronic vitamin A deficiency显示文摘 | R ROODENBURG AJ WEST CE HOVENIER | 1996 | Briti J Nutr1996，75，： | 1 |
| 10 | Syntheses in the naphthalene series显示文摘 | Soliman G West R W | 1944 | J Chem Soc1944，，： | 1 |
| 11 | Study of the capacity fading mechanism for Fe-substitute LiCoO2 positive electrode显示文摘 | Mclaren V L West A R Tabuchi M | 2004 | J Electrochem Soc2004，151，5： | 1 |
| 12 | Modulation of the prospective and retrospective components of memory for intentions in younger and older adults 显示文摘 | COHEN A L WEST R CRAIK F | 2001 | Aging Neuropsychol Cognition2001，，8： | 1 |
| 13 | New frontiers in food enzymology: recombinant lipoxygenases显示文摘 | Casey R West S I Hardy D David S Robinson Zecai W u Richard K Hughes | 1999 | Trends in Food Science & Technology1999，10，： | 1 |
| 14 | Corrosion and embrittlement in high-strength wires of suspension bridge cables 显示文摘 | BETTI R WEST A C VERMAAS G | 2005 | Journal of Bridge Engineering ASCE2005，10，2： | 1 |
| 15 | Genetically elevated non- fasting triglycerides and calculated remnant chalesteral as causal risk factors for myocardial infarction显示文摘 | JORGENSEN AB FRIKKE-SCHMIDT R WEST AS | 2013 | Eur Heart J2013，34，24： | 1 |
| 16 | Geography and vintage predicted by a novel GIS model of wine δ18O显示文摘 | West J B Ehleringer J R Cerling T E | 2007 | Journal of agricultural and food chemistry2007，55，17： | 1 |
| 17 | Behavioral correlates of individual differences in road traffic rash risk: an examination of methods and findings 显示文摘 | ELANDER J WEST R FRENCH D | 1993 | Psychology Bull1993，113，： | 1 |
| 18 | 7_2)6474 in combination with carboplatin and paclitaxel as first-line treatment in patients with NSCLC:Results of the run-in phase of a two-part randomized phase Ⅱ study显示文摘 | Heymach J West H Kerr R | 2005 | Lung Cancer2005，49，2： | 1 |
| 19 | Economic significance of tourism in Queensland显示文摘 | WEST G R | 1993 | Annals of Tourism Research1993，20，3： | 1 |
| 20 | Chemical stability enhancement of lithium conducting solid electrolyte plates using sputtered LiPON films显示文摘 | West W C Whitacre J F Lim J R | 2004 | J Power Sources2004，126，12： | 1 |
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