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| 1 | 非甾体抗炎药应用中,环氧合酶2、不对称二甲基精氨酸与心血管危害的关系显示文摘已有大规模、安慰剂对照试验确定了非甾体类抗炎药(nonsteroidal anti—inflammatory drugs,NSAIDs)具有心血管危害性:这归因于环氧合酶2(cyclooxygenase,COX-2)的心脏保护产物受到抑制,尤其是前列环素(prostacyclin,PG12)。NSAID降低心脏保护作用的另一种机制可能是通过增强肾脏中甲基精氨酸的形成来限制一氧化氮在整个脉管系统中的作用。 | Ricciotti E Castro C Tang SY Briggs WTE West JA Malik D Rhoades SD Meng H Li X Lahens NF Sparks JA Karlson EW Weljie AM Griffin JL FitzGerald GA6 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 3 |
| 2 | Enhanced caveolin-1 expression in smooth muscle cells: Possible prelude to neointima formation显示文摘AIM: To study the genesis of neointima formation in pulmonary hypertension(PH), we investigated the role of caveolin-1 and related proteins. METHODS: Male Sprague Dawley rats were given monocrotaline(M, 40 mg/kg) or subjected to hypobaric hypoxia(H) to induce PH. Another group was given M and subjected to H to accelerate the disease process(M + H). Right ventricular systolic pressure, right ventricular hypertrophy, lung histology for medial hypertrophy and the presence of neointimal lesions were examined at 2 and 4 wk. The expression of caveolin-1 and its regulatory protein peroxisome proliferator-activated receptor(PPAR) γ, caveolin-2, proliferative and antiapoptotic factors(PY-STAT3, p-Erk, Bcl-x L), endothelial nitric oxide synthase(e NOS) and heat shock protein(HSP) 90 in the lungs were analyzed, and the results from M + H group were compared with the controls, M and H groups. Double immunofluorescence technique was used to identify the localization of caveolin-1 in pulmonary arteries in rat lungs and in human PH lung tissue. RESULTS: In the M + H group, PH was more severe compared with M or H group. In the 4 wk M+H group, several arteries with reduced caveolin-1 expression in endothelial layer coupled with an increased expression in smooth muscle cells(SMC), exhibited neointimal lesions. Neointima was present only in the arteries exhibiting enhanced caveolin-1 expression in SMC. Lung tissue obtained from patients with PH also revealed neointimal lesions only in the arteries exhibiting endothelial caveolin-1 loss accompanied by an increased caveolin-1 expression in SMC. Reduction in e NOS and HSP90 expression was present in the M groups(2 and 4 wk), but not in the M + H groups. In both M groups and in the M + H group at 2 wk, endothelial caveolin-1 loss was accompanied by an increase in PPARγ expression. In the M + H group at 4 wk, increase in caveolin-1 expression was accompanied by a reduction in the PPARγ expression. In the H group, there was neither a loss of endothelial caveolin-1, eNOS or HSP 90, nor an increase in SMC caveolin-1 expression; or any alteration in PPARγ expression. Proliferative pathways were activated in all experimental groups. CONCLUSION: Enhanced caveolin-1 expression in SMC follows extensive endothelial caveolin-1 loss with subsequent neointima formation. Increased caveolin-1 expression in SMC, thus, may be a prelude to neointima formation. | Jing Huang John H Wolk Michael H Gewitz James E Loyd James West Eric D Austin Rajamma Mathew | 2015 | World Journal of Cardiology2015，7，10： | 2 |
| 3 | Forest succession models显示文摘 | WEST D C | 1980 | Bioscience1980，30，： | 1 |
| 4 | Characterization of H13 steel produced via electron beam melting显示文摘 | Cormier D Harrysson O West H | 2004 | Rapid Prototyping Journal2004，10，1： | 1 |
| 5 | A general model for the structure and allometry of plant vascular systems 显示文摘 | West G B Brown J H Enquist B J | 1999 | Nature1999，400，： | 1 |
| 6 | Development of Kimchi recipes suitable for British consumers and determination of vitamin C changes in Kimchi during storage显示文摘 | C H Ryu A West | 2000 | Food Science and Technology Today2000，14，2： | 1 |
| 7 | 显示文摘 | West J H Hench L L | 1991 | Bioceramics1991，5，： | 1 |
| 8 | Gefitinib (ZD1839) therapy for advanced brochioalverlar lung cancer (BAC) : Southwest Oncology Group (SWOG) Study S0126显示文摘 | West H Franklin WA Gumerlock PH | 2004 | Proc Am Soc Clin Oncol2004，23，： | 1 |
| 9 | When promoting positive feelings pays:Aggregate job satisfaction,work design features,and innovation in manufacturing organizations显示文摘 | Shipton H J West M A Parkes C L | 2006 | European Journal of Work and Organizational Psychology2006，15，4： | 1 |
| 10 | Characterization of H13 Steel Produced via Electron Beam Melting显示文摘 | CormIer D Harry sson 0 West H | 2004 | Rapid Pmtotyping2004，10，： | 1 |
| 11 | Structural basis for HIV-1 gp120 recognition by a germ-line version of a broadly neutralizing antibody显示文摘 | Scharf L West A P Jr Gao H | | 0，，： | 1 |
| 12 | 7_2)6474 in combination with carboplatin and paclitaxel as first-line treatment in patients with NSCLC:Results of the run-in phase of a two-part randomized phase Ⅱ study显示文摘 | Heymach J West H Kerr R | 2005 | Lung Cancer2005，49，2： | 1 |
| 13 | Cloning and Overexpression in Escherichia coli of the Gene Encoding Citrate Synthase from the Hyperthermophilic Archaeon Sulfolobus solfataricus显示文摘 | Clnnaris H West S M Hough D W | 1998 | Extremophiles1998，2，2： | 1 |
| 14 | Validity of the relative-dose- response test and the modified-relative-dose-response test as indicators of vitamin A stores in liver显示文摘 | VERHOEF H WEST C E | 2005 | Am J Clin Nutr2005，81，4： | 1 |
| 15 | Nitric oxide synthase(NOS)gene transfer modifies venous bypass graft remodeling:effects on vascular smooth muscle cell differentiation and superoxide production显示文摘 | West NE Qian H Guzik TJ | 2001 | Circulation2001，104，13： | 1 |
| 16 | Mycoardits and abortion associated with intrauterine infection of sows with porcine circovirus 2显示文摘 | West K H Bystrom J M Wojnarowicz C | 1999 | J Vet Diagnostic Invest1999，11，6： | 1 |
| 17 | Coloniza- tion of winter oilseed rape tissues by A/Tox + and B/ Tox0 Leptosphaeria maculans (phoma stem canker)in France and England 显示文摘 | West J S Balesdent M H T Rouxel J P | 2002 | Plant Pathology2002，，51： | 1 |
| 18 | Nitric Oxide Synthase (nNOS) Gene Transfer Modifies Venous Bypass Graft Remodeling显示文摘 | West NE Qian H Guzik TJ | 2001 | Circulation2001，104，13： | 1 |
| 19 | Understanding optimal colonic cancer surgery:comparison of Japanese D3 resec- tion and European complete mesocolic excision with central vascular ligation 显示文摘 | West N P Kobayashi H Takahashi K | 2012 | Journal of Clinical Oncology2012，30，15： | 1 |
| 20 | ZD6474 in combination with carboplatin and paclitaxel as first line treatment in patients with NSCLC :Results of the run - in phase of a two - part randomized phase Ⅱ study显示文摘 | Heymach J West H Kerr R | 2005 | Lung Cancer2005，49，12： | 1 |
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