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| 1 | Capecitabine and irinotecan with and without bevacizumab for advanced colorectal cancer patients显示文摘AIM:To investigate the efficacy and safety of capecitabine plus irinotecan±bevacizumab in advanced or metastatic colorectal cancer patients. METHODS:Forty six patients with previously untreated,locally-advanced or metastatic colorectal cancer(mCRC) were recruited between 2001-2006 in a prospective open-label phaseⅡtrial,in German community-based outpatient clinics.Patients received a standard capecitabine plus irinotecan(CAPIRI) or CAPIRI plus bevacizumab(CAPIRI-BEV) regimen every 3 wk. Dose reductions were mandatory from the first cycle in cases of>grade 2 toxicity.The treatment choice of bevacizumab was at the discretion of the physician.Theprimary endpoints were response and toxicity and secondary endpoints included progression-free survival and overall survival. RESULTS:In the CAPIRI group vs the CAPRI-Bev group there were more female than male patients(47% vs 24%) ,and more patients had colon as the primary tumor site(58.8%vs 48.2%) with fewer patients having sigmoid colon as primary tumor site(5.9%vs 20.7%) .Grade 3/4 toxicity was higher with CAPIRI than CAPIRI-Bev:82%vs 58.6%.Partial response rates were 29.4%and 34.5%,and tumor control rates were 70.6%and 75.9%,respectively.No complete responses were observed.The median progression-free survival was 11.4 mo and 12.8 mo for CAPIRI and CAPIRI-Bev,respectively.The median overall survival for CAPIRI was 15 mo(458 d) and for CAPIRI-Bev 24 mo(733 d) .These differences were not statistically different.In the CAPIRI-Bev,group,two patients underwent a full secondary tumor resection after treatment,whereas in the CAPIRI group no cases underwent this procedure. CONCLUSION:Both regimens were well tolerated and offered effective tumor growth control in this outpatient setting.Severe gastrointestinal toxicities and thromboembolic events were rare and if observed were never fatal. | Markus Moehler Martin F Sprinzl Murad Abdelfattah Carl C Schimanski Bernd Adami Werner Godderz Klaus Majer Dimitri Flieger Andreas Teufel Juergen Siebler Thomas Hoehler Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，4： | 10 |
| 2 | Does the stock market overreact显示文摘 | Bondt De Werner F M Thaler R H | 1985 | Journal of Finance1985，40，3： | 2 |
| 3 | Further evidence on investor overreaction and stock market seasonality显示文摘 | Bondt De Werner F M Thaler R H | 1987 | Journal of Finance1987，42，3： | 2 |
| 4 | Topology design,routing and capacity dimensioning for ISL networks in broadband LEO satellite systems显示文摘 | Werner M Reings J Wauquiez F | 2001 | International Journal of Satellite Communication2001，，： | 1 |
| 5 | Association of a lysine-232/alanine polymorphism in a bovine gene encoding acyl-CoA:diacylglycerol acyltransferase(DGAT1) with variation at a quantitative trait locus for milk fat content显示文摘 | Winter A Kramer W Werner F A at al | 2002 | Proc Natl Sci USA2002，99，14： | 1 |
| 6 | Quantum States with Einstein- Podolsky- Rosen correlations Admitting a Hidden- variable Model 显示文摘 | WERNER REINHARD F | 1989 | Phys Rev A1989，40，： | 1 |
| 7 | Topology design,routing and capacity dimensioning for ISL networks in broadband LEO satellite systems显示文摘 | M Werner J Reings F Wauquiez | 2001 | International Journal of Satellite Communication2001，，： | 1 |
| 8 | Results and insights from level-1 probabilistic safety assessments for nuclear power plants in France,Germany,Japan,Sweden,Switzerland and the United States 显示文摘 | Werner W F Hirano M Kondo S | 1995 | Reliability Eng and Syst Safety1995，48，： | 1 |
| 9 | Transforming growth factor- beta 1 inhibition of macrophage activation is mediated via Smad3 显示文摘 | Werner F Jain MK Feinberg MW | 2000 | J Bio Chem2000，275，36： | 1 |
| 10 | Forming limit diagrams: a micromechanical approach显示文摘 | GANSER H P WERNER E A FISCHER F D | 2000 | International Journal of Mechanical Sciences2000，42，12： | 1 |
| 11 | Effective stain removal:Ci- ba's Tinocat TRS KB1 oxidation catalyst is a gentle and cost-effective additive to laundry bleaching aids 显示文摘 | Hazenkamp M F Menno H Werner | 2006 | Household & Personal Prod- ucts Industry2006，43，： | 1 |
| 12 | Estimation of the beginning and end of recurrent events within a climate regime显示文摘 | GERSTENGARBE F W WERNER P C | 1999 | Climate Research1999，11，： | 1 |
| 13 | Numerical simulation of turbulentflow over surface mounted obstacles with sharp edges and corners 显示文摘 | Baetke F Werner H Wengle H | 1990 | Journal of Wind Engineering and Industrial Aerodynamics1990，35，： | 1 |
| 14 | Scaling of microwave slot antenna (SLAN): a concept for efficient plasma generation显示文摘 | Korzec D Werner F Winter R | 1996 | Plasma Sources Science Technology1996，5，： | 1 |
| 15 | Infecti Spine Surge Treatment显示文摘 | Werner B C Shen F H ShimerA L | 2011 | ons After Lumbar ry:hvoidance Seminars in SurgeryComplications in Lumbar and Spine SpineSurgery2011，23，2： | 1 |
| 16 | PKCgamma is required for ethanol-induced increases in GABA(A) recep- tor alpha4 subunit expression in cultured cerebral cortical neurons 显示文摘 | Werner D F Kumar S Criswell H E | 2011 | J Neuroehem2011，116，4： | 1 |
| 17 | Okkulte lymphatische Tumorzelldisseminierung beim Pankreaskarzinom显示文摘 | C. Milsmann L. Füzesi C. Werner H. Becker PD Dr. O. Horstmann | 2005 | Der Chirurg2005，，11： | 1 |
| 18 | Quantum states with Einstein-Podol- sky-Rosen correlations admitting a hidden-variable model 显示文摘 | WERNER R F | 1989 | Physical Review A1989，40，： | 1 |
| 19 | Balanced analgesia:What is it and what are its advantages in postoperative pain?显示文摘 | Kehlet H Werner M Perkins F | 1999 | Drugs1999，58，： | 1 |
| 20 | Transforming growth factor-beta 1 inhibition of macrophage activation is mediated via Smad3显示文摘 | Werner F Jain MK Feinberg MW | 2000 | J Biol Chem2000，275，36： | 1 |
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