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| 1 | mi R-122 negatively correlates with liver fibrosis as detected by histology and FibroScan显示文摘AIM: To investigate whether expression of selected mi RNAs obtained from fibrotic liver biopsies correlate with fibrosis stage.METHODS: Altogether, 52 patients were enrolled in the study representing various etiologic backgrounds of fibrosis: 24 cases with chronic hepatitis infections(types B, C), 19 with autoimmune liver diseases(autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, overlapping syndrome cases), and 9 of mixed etiology(alcoholic and nonalcoholic steatosis, cryptogenic cases). Severity of fibrosis was determined by both histologic staging using the METAVIR scoring system and noninvasive transient elastography. Following RNAisolation, expression levels of mi R-21, mi R-122, mi R-214, mi R-221, mi R-222, and mi R-224 were determined using Taq Man Micro RNA Assays applying mi R-140 as the reference. Selection of mi RNAs was based on their characteristic up- or downregulation observed in hepatocellular carcinoma. Relative expression of mi RNAs was correlated with fibrosis stage and liver stiffness(LS) value measured by transient elastography, as well as with serum alanine aminotransferase(ALT) level.RESULTS: The expression of individual mi RNAs showed deregulated patterns in stages F1-F4 as compared with stage F0, but only the reduced level of mi R-122 in stage F4 was statistically significant(P < 0.04). When analyzing mi RNA expression in relation to fibrosis, levels of mi R-122 and mi R-221 showed negative correlations with fibrosis stage, and mi R-122 was found to correlate negatively and mi R-224 positively with LS values(all P < 0.05). ALT levels displayed a positive correlation with mi R-21(P < 0.04). Negative correlations were observed in the fibrosis samples of mixed etiology between mi R-122 and fibrosis stage and LS values(P < 0.05), and in the samples of chronic viral hepatitis, between mi R-221 and fibrosis stage(P < 0.01), whereas mi R-21 showed positive correlation with ALT values in the samples of autoimmune liver diseases(P < 0.03). The results also revealed a strong correlation between fibrosis stage and LS values(P < 0.01) when etiology of fibrosis was not taken into account.CONCLUSION: Reduced expression of mi R-122 in advanced fibrosis and its correlation with fibrosis stage and LS values seem to be characteristic of hepatic fibrosis of various etiologies. | Tünde Halász Gábor Horváth Gabriella Pár Klára Werling András Kiss Zsuzsa Schaff Gábor Lendvai | 2015 | World Journal of Gastroenterology2015，21，25： | 11 |
| 2 | 不均匀电场中温度对油纸绝缘沿面放电特性的影响显示文摘采用针-板电极结构研究不均匀电场中温度对变压器油纸绝缘沿面放电特性的影响。首先,确定油纸绝缘的局部放电起始电压和闪络电压。然后,在油纸界面上施加恒定电压,研究在不同温度下施加长期电压时油纸绝缘的沿面放电特性。结果表明:局部放电起始电压和闪络电压随温度升高而增加。施加长期电压时,高油温下,油纸绝缘沿面放电现象和纸板变化情况更为复杂。纸板在高油温下更容易发生碳化。虽然碳化会对纸板造成不可逆的损坏,但仅在表面发生碳化的纸板在恒定电压下表现出更长的耐压时间和更低的局部放电量与放电重复率。然而,在内部发生严重碳化时,其局部放电重复率变得更高,最终导致纸板击穿。 | 黎颖 周欣 Werle P 郑晓泉 | 2018 | 绝缘材料2018，51，6： | 5 |
| 3 | Signalprocessing and calibration procedures for in situ diode-laser absorption spectroscopy显示文摘 | Werle P W Mazzinghi P Amatoa F D | 2004 | Spectrochimica ActaPart A2004，，60： | 1 |
| 4 | A review of recent advances in semiconductor laser based on gas monitors显示文摘 | Werle P | 1998 | Spectrochimica Acta Part A1998，54，： | 1 |
| 5 | Evolution ofhepatitis B viral load and viral genome sequence during adefovirdipivoxil therapy显示文摘 | WERLE B CINQUIN K MARCELLIN P | 2004 | Viral Hepat2004，11，1： | 1 |
| 6 | Near-infrared trace-gas sensors based on room-temperature diode lasers显示文摘 | P Werle R Mticke F D Amato | 1998 | Appl Phys B1998，67，3： | 1 |
| 7 | A review of recent advances in semiconductor laser based gas monitors显示文摘 | | 1998 | Spectrochimica Acta part A1998，，54： | 1 |
| 8 | Near and mid-infrared lasePoptical sensors for gas analysis 显示文摘 | WERLE P SLEMR F MAURER K et aI | 2002 | Optics and Lasers in Engineering2002，37，23： | 1 |
| 9 | Near-and Mid-Infrared Laser-Optical Sensors for Gas Analysis 显示文摘 | WERLE P SLEMR F MAURER K | 2002 | Optics and Lasers inEngineering(S0143-8166)2002，37，2： | 1 |
| 10 | Involvement of caveolae in the uptake of respiratory syncytial virus antigen by dendritic cells显示文摘 | WERLING D HOPE J C CHAPLIN P | 1999 | Journal of Leuko- cyte Biology1999，66，1： | 1 |
| 11 | Near-and mid-infrared laser-optical sensors for gas analysis 显示文摘 | Werle P Slemr F Karl | 2002 | Optics and Lasers in Engineer-ing2002，37，： | 1 |
| 12 | Evolution of hepatitis B viral load and viral genome sequence during adefovir dipivoxil therapy显示文摘 | Werle B Cinquin K Marcellin P | 2004 | J Viral Hepat2004，11，1： | 1 |
| 13 | Transfer Functionbased Partial Discharge Localization in Power Transformers: a Feasibility Study 显示文摘 | Akbari A Werle P Borsi H | 2002 | Electrical Insulation Magazine IEEE2002，18，5： | 1 |
| 14 | Application of antimonide lasers for gas sensing in the 3-4 μm range显示文摘 | Werle P Popov A | 1999 | Applied Optics1999，38，9： | 1 |
| 15 | Near-and mid-infrared laser-optical sensors for gas analysis显示文摘 | Werle P Slemr F Maurer K | 2002 | Optics and La- sers in Engineering2002，37，2： | 1 |
| 16 | Numerical modeling of mass transfer in the supercritical antisolvent process:miscible conditions显示文摘 | Werling J O Debenedetti P G | 2000 | J of Supercrit ical Fluids2000，18，： | 1 |
| 17 | Effects of pyrimidine and purine analog combinations in the duck hepatitis B virus infection model显示文摘 | Seignères B Martin P Werle B Schorr O Jamard C Rimsky L | | Antimicrobial Agents and Chemotherapy0，，： | 1 |
| 18 | A review of recent advances in semiconductor laser based gas monitors 显示文摘 | Werle P | 1998 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy1998，54，2： | 1 |
| 19 | Ueber das yon kallikrein in der speicheldruesen and in mundspechel显示文摘 | Werle E Roden P | 1936 | Biochem Z1936，286，11： | 1 |
| 20 | Numerical modeling of mass transfer in the supercritical antisolvent process:miscible conditions显示文摘 | Werling J O Debenedetti P G | 2000 | J Supercrit Fluid2000，18，1： | 1 |
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