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| 1 | Phase angle obtained by bioelectrical impedance analysis independently predicts mortality in patients with cirrhosis显示文摘AIM To evaluate the prognostic value of the phase angle(PA)obtained from bioelectrical impedance analysis(BIA) for mortality prediction in patients with cirrhosis. METHODS In total, 134 male cirrhotic patients prospectively completed clinical evaluations and nutritional assessment by BIA to obtain PAs during a 36-mo follow-up period. Mortality risk was analyzed by applying the PA cutoff point recently proposed as a malnutrition marker(PA ≤ 4.9°) in Kaplan-Meier curves and multivariate Cox regression models. RESULTS The patients were divided into two groups according to the PA cutoff value(PA > 4.9°, n = 73; PA ≤ 4.9°, n = 61). Weight, height, and body mass index were similar in both groups, but patients with PAs > 4.9° were younger and had higher mid-arm muscle circumference, albumin, and handgrip-strength values and lower severe ascites and encephalopathy incidences, interleukin(IL)-6/IL-10 ratios and C-reactive protein levels than did patients with PAs ≤ 4.9°(P ≤ 0.05). Forty-eight(35.80%) patients died due to cirrhosis, with a median of 18 mo(interquartile range, 3.3-25.6 mo) follow-up until death. Thirty-one(64.60%) of these patients were from the PA ≤ 4.9° group. PA ≤ 4.9° significantly and independently affected the mortality model adjusted for Model for End-Stage Liver Disease score and age(hazard ratio = 2.05, 95%CI: 1.11-3.77, P = 0.021). In addition, Kaplan-Meier curves showed that patients with PAs ≤ 4.9° were significantly more likely to die. CONCLUSION In male patients with cirrhosis, the PA ≤ 4.9° cutoff was associated independently with mortality and identified patients with worse metabolic, nutritional, and disease progression profiles. The PA may be a useful and reliable bedside tool to evaluate prognosis in cirrhosis. | Giliane Belarmino Maria Cristina Gonzalez Raquel S Torrinhas Priscila Sala Wellington Andraus Luiz Augusto Carneiro D'Albuquerque Rosa Maria R Pereira Valéria F Caparbo Graziela R Ravacci Lucas Damiani Steven B Heymsfield Dan L Waitzberg | 2017 | World Journal of Hepatology2017，9，7： | 11 |
| 2 | ABC1 mRNA and protein distribution patterns predict multiple different roles and levels of regulation显示文摘 | Wellington CL Walker EK Suarez A Kwok A Bissada N Singaraja R | 2002 | Lab invest2002，82，3： | 1 |
| 3 | Drying and autogenous shrinkage of pastes and mortars with activated slag cement 显示文摘 | Antonio A M N Maria A C Wellington R | 2008 | Cement and Concrete Research2008，38，4： | 1 |
| 4 | Mechanical properties, dying and autogenous shrinkage of blast furnace slag activated with hydrated lime and gypsum显示文摘 | Antonio A M N Maria A C Wellington R | 2010 | Cement and Concrete Composites2010，32，4： | 1 |
| 5 | Calibration of stable oxygen isotope signatures in Galapagos corals显示文摘 | Wellington G M Dunbar R B Merlen G | 1996 | Paleoceanography1996，11，4： | 1 |
| 6 | The NIH human microbiome project显示文摘 | NIH HMP Working Group Peterson J Garges S Giovanni M McInnes P Wang L Schloss JA Bonazzi V McEwen JE Wetterstrand KA Deal C Baker CC Di Francesco V Howcroft TK Karp RW Lunsford RD Wellington CR Belachew T Wright M Giblin C David H Mills M Salomon R Mullins C Akolkar B Begg L Davis C Grandison L Humble M Khalsa J Little AR Peavy H Pontzer C Portnoy M Sayre MH Starke-Reed P Zakhari S Read J Watson B Guyer M | 2009 | Genome Res2009，19，12： | 1 |
| 7 | Clinical efficacy of milbemycin oxime in the treatment of generalized demodicosis in a- dult dogs 显示文摘 | Miller W H Scott D W Wellington J R | 1993 | Journal of the American Veterinary Medical Associa- tion1993，203，： | 1 |
| 8 | Prevention of venous thromboembolic disease after total hip and knee athroplasty显示文摘 | Lieberman Wellington K | 2005 | JBJS2005，87，2： | 1 |
| 9 | Time-Resolved Laser-Induced Fluorescence study of photoinduced electron transfer at the water/1,2-Dichloroethane interface显示文摘 | DRYFE W DING Z F WELLINGTON R G | 1997 | J Phys Chem A1997，101，： | 1 |
| 10 | Inhibiting caspase cleavage of huntingtin reduces toxieity and aggregate formation in neuronal and noneuronal cells 显示文摘 | Wellington CL Singaraja R Ellerby L | 2000 | J Biol Chem2000，275，19： | 1 |
| 11 | Caspases and neurodegeneration: on the cutting edge of new therapeutic approaches 显示文摘 | Wellington C L Hayden M R | 2000 | Clin Genet2000，57，1： | 1 |
| 12 | Drying and autogenous shrinkage of pastes and mortars with activated slag cement显示文摘 | Antonio A M N Maria A C Wellington R | 2008 | Cement and Concrete Research2008，38，4： | 1 |
| 13 | Mendelian inheritance of epidermal characters in the fruit of Cucumis sativus显示文摘 | WELLINGTON R | 1913 | Science1913，38，： | 1 |
| 14 | Pathophysiology of white matter perfusion in Alzheimer's disease and vascular dementia 显示文摘 | Barker R Ashby EL Wellington D | 2014 | Brain2014，137，5： | 1 |
| 15 | Bioequivalence study of finasteride显示文摘 | Wellington R Demian RI | 2001 | Arzneim Forsch Drug Res2001，51，1： | 1 |
| 16 | Recovering polyploid papaya in vitro regenerants as screened by flow cytometry显示文摘 | Wellington R C de Carlos R C Femanda S A | 2008 | Plant Cell Tiss Organ Cult2008，92，： | 1 |
| 17 | Mendelian inheritance of epidermal characters in the fruit of Cucumis sativus 显示文摘 | Wellington R | 1913 | Science1913，38，： | 1 |
| 18 | Eastern Pacific sea surface temperature since 1600 AD: the δ^18O record of climate variability in Galdpagos corals 显示文摘 | Dunbar R B Wellington G M Colgan M W | 1994 | Coral Reefs1994，9，： | 1 |
| 19 | The cadmiuminduced disruption of tight junction in LLC - PK1 cells dose not result from apoptosis显示文摘 | Prozialeck W C Wellington D R Mosher T L | 1995 | L1FE SCI1995，5714，： | 1 |
| 20 | Mutipoint covalent immobilization microbial lipase on chitosan and agarose activated by different methods显示文摘 | DASCIANA S R ADRIANO A M WELLINGTON S A | 2008 | Journal of Molecular Catalysis B:Enzymatic2008，51，： | 1 |
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