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| 1 | Alcoholic pancreatitis:New insights into the pathogenesisand treatment显示文摘Acute pancreatitis is a necro-inflammatory disease of the exocrine pancreas that is characterized by inappropriate activation of zymogens, infiltration of the pancreas by inflammatory cells, and destruction of the pancreatic exocrine cells. Acute pancreatitis can progress to a severe life-threatening disease. Currently there is no pharmacotherapy to prevent or treat acute pancreatitis. One of the more common factors associated with acute pancreatitis is alcohol abuse. Although commonly associated with pancreatitis alcohol alone is unable to cause pancreatitis. Instead, it appears that alcohol and its metabolic by-products predispose the pancreas to damage from agents that normally do not cause pancreatitis, or to more severe disease from agents that normally cause mild pancreatic damage. Over the last 10 to 20 years, a tremendous amount of work has defined a number of alcohol-mediated biochemical changes in pancreatic cells. Among these changes are: Sustained levels of intracellular calcium, activation of the mitochondrial permeability transition pore, endoplasmic reticulum stress, impairment in autophagy, alteration in the activity of transcriptional activators, and colocalization of lysosomal and pancreatic digestive enzymes. Elucidation of these changes has led to a deeper understanding of the mechanisms by which ethanol predisposes acinar cells to damage. This greater understanding has revealed a number of promising targets for therapeutic intervention. It is hoped that further investigation of these targets will lead to the development of pharmacotherapy that is effective in treating and preventing the progression of acute pancreatitis. | Dahn L Clemens Katrina J Schneider Christopher K Arkfeld Jaclyn R Grode Mark A Wells Shailender Singh | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 10 |
| 2 | Mobile Ubiquitous Service Environment显示文摘The Mobile Ubiquitous Service Environment (MUSE),established through the coordination and integration of mobile telecommunications and ubiquitous network,in the pursuit of Always Best Experience (ABE),represents the major development trend for the next generation mobile wireless network. Research on MUSE will involve the integration of the computing model system,service platform system,operating system and terminal structure system,all of which involve exploration and innovation of a new networking structure,its control and management as well as way of measuring. The change in network resources triggers the change in network computing models. To let readers have a basic understanding of MUSE,this lecture introduces it in four sections. This section focuses on the development and demand analysis of the service platform. | Zhang Ping,Ji Yang,Feng Zhiyong (Research Center for Wireless New Technology,Beijing University of Posts and Telecommunications,Beijing 100876,China) The Mobile Ubiquitous Service Environment (MUSE),established through the coordination and integration of mobile telecommunications and ubiquitous network,in the pursuit of Always Best Experience (ABE),represents the major development trend for the next generation mobile wireless network. Research on MUSE will involve the integration of the computing model system,service platform system,operating system and terminal structure system,all of which involve exploration and innovation of a new networking structure,its control and management as well as way of measuring. The change in network resources triggers the change in network computing models. To let readers have a basic understanding of MUSE,this lecture introduces it in four sections. This section focuses on the development and demand analysis of the service platform. | 2007 | ZTE Communications2007，5，2： | 10 |
| 3 | 静脉血栓栓塞症的抗血栓治疗:美国《胸科学》杂志指南显示文摘包括深静脉血栓和肺栓塞在内的静脉血栓栓塞症是癌症患者的主要并发症,发生率为4%~20%,并且是常见的潜在致命性急症。本文介绍了美国《胸科学》杂志指南中VET的抗血栓治疗的部分内容,其以第9版《美国胸内科医师学会循证临床实践指南》中的《静脉血栓栓塞症的抗血栓治疗:抗血栓治疗和阻止血栓形成》一文为参照,基于静脉血栓栓塞症治疗的Ⅲ期试验的发表年份,对口服抗凝剂(达比加群、利伐沙班、阿哌沙班、依度沙班)进行先后阐述(但是这一排序并不是指南专家组对药剂的优劣排序),以为临床医生提供参考。 | Kearon C Akl EA Ornelas J Blaivas A Jimenez D Bounameaux H Huisman M King CS MorrisT Sood N Stevens SM Vintch JRE Wells P Woller SC Moores CL 本刊编辑部 | 2016 | 中国全科医学2016，19，9： | 10 |
| 4 | Eek,a Xenomouse:Abgenix Inc 显示文摘 | WELLS W A | 2000 | Chem Biol2000，7，8： | 2 |
| 5 | Design of a Multi--Vehicle Control Sys tern: System Design and User Interaction显示文摘 | WElL Shawn A | 2006 | Advances in Hu man Performance and Cognitive Engineering Research2006，，7： | 1 |
| 6 | Imaging of bacterial infections with 99mTc-labeled human neutrophil peptide-1显示文摘 | Welling MM Nibbering PH Paulusma-Annema A | 1999 | J Nucl Med1999，40，： | 1 |
| 7 | Fire-related sedimentation events on alluvial fans, Yellowstone National Park USA 显示文摘 | Meyer G A Wells S G | 1997 | Journal of Sedimentary Research1997，67，5： | 1 |
| 8 | The Determinants of Venture Capital Funding : Evidence Across Countries 显示文摘 | Jengl A Wells P C | 2000 | Journal of Corporate Finance2000，，6： | 1 |
| 9 | Meta--cognition and worry: A cognitive model of generalized anxiety disorder显示文摘 | Wells A | 1995 | Behavioral and Cognitive Psychotherapy1995，23，5： | 1 |
| 10 | Risedronate for the primary andsecondary prevention of osteoporotic fractures in postmenopausal women显示文摘 | Wells GA Cranney A Peterson J | 2008 | Cochrane Database Syst Rev2008，，00： | 1 |
| 11 | A study of the use of milk replacers for dairy calves in the United States显示文摘 | Heinrichs A J Wells S J Losinger W C | 1995 | J Dairy Sci1995，，78： | 1 |
| 12 | Cardiac-resynchronization ther-apy for mild-to-moderate heart failure显示文摘 | Tang A S Wells G A Talajic M | | 0，，25： | 1 |
| 13 | Earnouts in mergers and acquisitions: a game-theoretic option pricing approach 显示文摘 | Lukas E Reuer J J Welling A | 2012 | European Journal of Operational Research2012，223，1： | 1 |
| 14 | Cognitive therapy:applications for health promotion,disease prevention,and disease management显示文摘 | Wells Federman CL Stuart Shor E Webster A | 2001 | Nurs Clin North Am2001，36，1： | 1 |
| 15 | Technetium-99m labelled antimicrobial peptides discriminate between bacterial infections and sterile inflammations显示文摘 | Welling MM Paulusma-Annema A Balter HS | 2000 | Eur J Nucl Med2000，27，： | 1 |
| 16 | Factors associated with pressure ulcers in adults in acute care hospitals显示文摘 | FISH ER A R WELL S G HARRISON M B | 2004 | Holist Nurs Pract2004，18，5： | 1 |
| 17 | Activation of specific apoptotic caspases with an engineered small - molecule - activated protease显示文摘 | GRAY D C MAHRUS S WELLS J A | 2010 | Cell2010，142，4： | 1 |
| 18 | Antioxidants as therapy in the newborn:some words of caution显示文摘 | Jankov RT Negus A Tans well AK | 2001 | Pediatr Res2001，50，6： | 1 |
| 19 | Transport of genistein-7-glucoside by human intestinal Caco-2 cells: poteintial role for MRP2 显示文摘 | Wells U K French K L Walgren R A | 1999 | Res Comm Mole Pathol Pharm1999，103，1： | 1 |
| 20 | Meat-analysis of calcium supplementation for the prevention of postmenopausal osteoporosis 显示文摘 | SHEA B WELLS G GRANNEY A | 2002 | Endocr Rev2002，3，4： | 1 |
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