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| 1 | 笋芽顶端分生组织在竹秆横切面形态形成中的作用与机制研究显示文摘竹秆的横切面主要由表皮、皮层、维管组织、基本组织及髓腔(早期为髓组织)组成。这些组织均由笋芽茎顶端分生组织分化发育而来,且其在生长发育过程中促使了竹秆横切面形态(本文特指:竹秆横切面外轮廓形状、围度及壁-腔结构)的形成。然而,人们对于这一生长发育过程的生物学机制知之甚少。本研究利用解剖学、数学模拟等方法,对 20 种具不同秆径竹种的笋芽顶端分生组织进行了分析。研究结果发现,笋芽顶端分生组织指状形态的维持是竹子产生圆柱形竹秆的基础;在顶端分生组织细胞数目增加的同时,线性增加原体细胞数目应是竹子在演化过程中产生大径竹秆且保持规则壁-腔结构的方式。进一步通过研究一个竹壁增厚且壁-腔架构紊乱的稳定变异体———实肚竹( Phyllostachys nidularia f. farcta)发现,其笋芽顶端分生组织细胞数目减少且原体/原套细胞数比值降低使其产生了高比例的壁组分组织(指基本分生组织与肋状分生组织)与低比例的髓组织。上述 2 种组织的比例失衡,使得实肚竹笋芽在后续发育中壁组分组织随机挤入到了髓组织中,最终形成了实肚竹异常的竹秆横切面形态(竹壁多样化增厚且壁-腔结构紊乱)。此外,相对较小的顶端分生组织,使得实肚竹笋芽产生了较少的内源激素,如其生长素含量仅约为其原种篌竹的 67. 5%,各细胞分裂素含量也显著低于篌竹笋芽。转录组分析进一步发现,在实肚竹笋芽中与激素及代谢相关的功能基因呈显著下调表达。这些生理与分子变化最终导致了实肚竹竹秆矮化、秆径减小且生物量降低。本论文的研究结果为研究竹秆横切面发育提供了一个重要的视角,同时也为实肚竹厚壁茎秆的形成提出了一个合理的机制。 | Wang Y Sun X Ding Y Fei Z Jiao C Fan M Yao B Xin P Chu J Wei Q 王雨珺 魏强 | 2019 | 世界竹藤通讯2019，17，3： | 5 |
| 2 | 查看详情显示文摘 | X L Wang Y H Chen R J Wei | | 中国物理快报(英文版)0，，： | 3 |
| 3 | The genetic heterozygosity and fitness of tetraploid embryos and embryonic stem cells are crucial parameters influencing survival of mice derived from embryonic stem cells by tetraploid embryo aggregation显示文摘 | Li X Wei W Yong J Jia Q Yu Y Di K | 2006 | 中国生物学文摘2006，20，7： | 3 |
| 4 | Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain (BARD1) gene are associated with breast cancer susceptibility:a case-control analysis显示文摘The BRCA1 Associated RING Domain(BARD1) gene has been identified as a high penetrance gene for breast cancer, whose germline and somatic mutations were reported in both non-BRCA1/2 hereditary site-specific and sporadic breast cancer cases. BARD1 plays a crucial role in tumor repression, along with its heterodimeric partner BRCA1. In the current study, we tested the hypothesis that common non-synonymous polymorphisms in BARD1 are associated with breast cancer susceptibility in a case-control study of 507 patients with incident breast cancer and 539 frequency-matched cancer-free controls in Chinese women. We genotyped all three common(minor allele frequency (MAF) > 0.10) non-synonymous polymorphisms(Pro24Ser, Arg378Ser, and Val507Met) in BARD1. We found that the BARD1 Pro24Ser variant genotypes(24Pro/Ser and 24Ser/Ser) and Arg378Ser variant homozygote 378Ser/Ser were associated with a significantly decreased breast cancer risk, compared with their wild-type homozygotes, respectively. Furthermore, a significant locus-locus interaction was evident between Pro24Ser and Arg378Ser (P-int = 0.032). Among the 378Ser variant allele carriers, the 24Pro/Pro wild-type homozygote was associated with a significantly increased breast cancer risk (adjusted OR = 1.81, 95% CI = 1.11-2.95), but the subjects having 24Pro/Ser or Ser/Ser variant genotypes had a significantly decreased risk(adjusted OR = 0.74, 95% CI = 0.56-0.99). In stratified analysis, this locus-locus interaction was more evident among subjects without family cancer history, those with positive estrogen receptor (ER) and individuals with negative progesterone receptor(PR). These findings indicate that the potentially functional polymorphisms Pro24Ser and Arg378Ser in BARD1 may jointly contribute to the susceptibility of breast cancer. | Huo, X Hu, Z. B Zhai, X. J Wang, Y Wang, S Wang, X. C Qin, J. W Chen, W. S Jin, G. F Liu, J. Y Gao, J Wei, Q. Y Wang, X. R Shen, H. B | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 3 |
| 5 | A modified transcystic biliary decompression after laparoscopic choledochotomy显示文摘 | Wei Q Cai X Yang J | 2004 | J Laparoendosc Adv Surg Tech A2004，14，1： | 1 |
| 6 | 显示文摘 | Wei Y Wang J G Jia X R | 1995 | Polymeric Materials Science and Engineering1995，72，： | 1 |
| 7 | A common modeling framework of voltage-sourced converters for load flow, sensitivity, and dispatch analysis显示文摘 | Wei X Chow J H Fardanesh B | 2004 | IEEE Trans on Power Systems2004，19，2： | 1 |
| 8 | Macroscopic three-dimensional arrays of Fe nanoparticles supported in aligned carbon nanotubes显示文摘 | CAO A ZHANG X WEI J | 2001 | J Phys Chem B2001，105，11： | 1 |
| 9 | Measurement of the Elastic Properties and Intrinsic Strength of Monolayer Graphene 显示文摘 | Lee C G Wei X D Kysar J W el al | 2008 | Science2008，321，5887： | 1 |
| 10 | Measurement of the ela-stic properties and intrinsic strength of monolayer graphene显示文摘 | Lee C Wei X D Kysar J W | 2008 | Science2008，321，5887： | 1 |
| 11 | Analysis of extension propagation process of an interface crack between belts of a radial tire using a finite element method 显示文摘 | Feng X J Yan X Q Wei Y T | 2004 | Applied Mathematical Modelling2004，28，2： | 1 |
| 12 | 查看详情显示文摘 | Wei Y Connors E J Jia X R Wang C | | 0，，： | 1 |
| 13 | Isolation and characterization endophytic bacteria from Sedum alfredii Hance and their potential to promote phytoextraction of zinc polluted soil 显示文摘 | LONG X X CHEN X M CHEN Y G WONG J W WEI Z B WU Q T | 2010 | World Journal Microbiology Biotechnology2010，27，： | 1 |
| 14 | Measurement of the elastic properties and intrinsic strength of monolayer graphene显示文摘 | Lee C Wei X Kysar J W | 2008 | Science2008，321，5887： | 1 |
| 15 | Sensitive and rapid detection of the new Delhi metallo-beta- lactamase gene by loop-mediated isothermal amplification 显示文摘 | Liu W Zou D Li Y Wang X He X Wei X Shao C Li X Shang W Yu K Liu D Li Y Guo J Yin Z Yuan J | 2012 | J Clin Microbiol2012，50，5： | 1 |
| 16 | Signaling events in amyloid beta-peptide-induced neuronal death and insulin-like growth factor I protection显示文摘 | WEI W WANG X KUSIAK J W | 2002 | Journal of Biological Chemistry2002，277，17： | 1 |
| 17 | Measurement of the elastic properties and intrinsic strength of monolayer graphene显示文摘 | LEE C WEI X KYSAR J W HONE J | 2008 | Science2008，321，5887： | 1 |
| 18 | Preparation and properties of novel inherent flame-retardant cyclotriphosphazene-containing epoxy resins 显示文摘 | Liu F F Wei H Huang X B Zhang J W Zhou Y B Tang X Z | 2010 | Journal of Macromolecular Science Part B: Physics2010，49，5： | 1 |
| 19 | Measurement of the e- lastic properties and intrinsic strength on monolayer gra- phene显示文摘 | Lee C G Wei X D Kysar J W | 2008 | Science2008，321，5887： | 1 |
| 20 | Astrgalus mongholius and polygonum multiflorun s protective function against eyclophoshamide inhibitory effect on thymns显示文摘 | Wei X Zhang J | 2004 | Am J Chin Med2004，32，5： | 1 |
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