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| 1 | Rational use of mesenchymal stem cells in the treatment of autism spectrum disorders显示文摘Autism and autism spectrum disorders(ASD) refer to a range of conditions characterized by impaired social and communication skills and repetitive behaviors caused by different combinations of genetic and environmental influences. Although the pathophysiology underlying ASD is still unclear, recent evidence suggests that immune dysregulation and neuroinflammation play a role in the etiology of ASD. In particular, there is direct evidence supporting a role for maternal immune activation during prenatal life in neurodevelopmental conditions. Currently, the available options of behavioral therapies and pharmacological and supportive nutritional treatments in ASD are only symptomatic. Given the disturbing rise in the incidence of ASD, and the fact that there is no effective pharmacological therapy for ASD, there is an urgent need for new therapeutic options. Mesenchymal stem cells(MSCs) possess immunomodulatory properties that make them relevant to several diseases associated with inflammation and tissue damage. The paracrine regenerative mechanisms of MSCs are also suggested to be therapeutically beneficial for ASD.Thus the underlying pathology in ASD, including immune system dysregulation and inflammation, represent potential targets for MSC therapy. This review willfocus on immune dysfunction in the pathogenesis of ASD and will further discuss the therapeutic potential for MSCs in mediating ASD-related immunological disorders. | Qiang Liu Mo-Xian Chen Lin Sun Chloe U Wallis Jian-Song Zhou Li-Juan Ao Qi Li Pak C Sham | 2019 | World Journal of Stem Cells2019，11，2： | 5 |
| 2 | Multiple forms of hydroxycinnamate:CoA ligase in etiolated pea seedling显示文摘 | RHODES M J C | 1977 | Phytochemistry1977，16，： | 1 |
| 3 | Validation of a onedimensional wave model for the stratified-to-slug flow regime transition, with consequences for wave growth and slug frequency 显示文摘 | Crowley C J Wallis G B Barry J J | 1992 | Int J Multiphase Flow1992，18，2： | 1 |
| 4 | Evaluation of four mycobacterial blood culture media:Bactec 13A,Isolator/Bactec 12B,Isolator/Middlebrook agar and a biphasic medium显示文摘 | Agy M B Wallis C K Plorde J J | 1989 | Microbiol Infect Dis1989，12，： | 1 |
| 5 | Molecular mechanisms underlying Bile acid-stimulated glucagon-like peptide-1 secretion显示文摘 | Parker H E Wallis K Roux C W | 2012 | Br J Pharmacol2012，165，2： | 1 |
| 6 | Pathology teach and tell: eosinophilic granuloma 显示文摘 | Khalil F K Wallis Crespo M C Gilbert Barness E | 2004 | Fetal Pediatr Pathol2004，23，4： | 1 |
| 7 | An analysis of expressed sequence tags of developing castor endosperm using a full - length cDNA library 显示文摘 | Lu C F Wallis J G Browse J | 2007 | BMC Plant biology2007，7，： | 1 |
| 8 | Blood culture negative endocarditis:a diagnostic challenge 显示文摘 | Walli F Chuard C Regamey C | 2005 | Rev Med Suisse2005，1，36： | 1 |
| 9 | Validation of a one-dimensional wave model for the stratified-to-slug flow regime transition, with consequences for wave growth and slug frequency显示文摘 | CROWLEY C J WALLIS G B BARRY J J | 1992 | International Journal of Multiphase Flow1992，18，2： | 1 |
| 10 | Quantitation of haemagglutinin in H5N1 influenza viruses reveals low haemagglutinin content of vaccine virus NIBRG-14(H5N1)显示文摘 | Havey R Wheeler J X Wallis C L | 2008 | Vaccine2008，26，： | 1 |
| 11 | Muscarinic antagonists in development for disorders of smooths muscle function显示文摘 | Wallis R M Napic C M | 1999 | Life Sci1999，64，7： | 1 |
| 12 | lntermetallics显示文摘 | Wallis I C Ubhi H S Bacos M P | 2004 | 12:3032004，12，： | 1 |
| 13 | The onset of slugging in horizontalstratified air water flow 显示文摘 | Wallis C B Dobson J E | 1973 | Int J Multiphase flow1973，1，1： | 1 |
| 14 | Plasma-assis-ted catalysis for the destruction of CFC-12in atmosphericpressure gas streams using TiO2显示文摘 | WALLIS A E WHITEHEAD J C ZHANG K | 2007 | Catalysis Letters2007，113，12： | 1 |
| 15 | The Crystal Structure of Iron-free Human Serum Transferrin Provides Insight Into Inter-lobe Communication and Receptor Binding显示文摘 | Wally J Halbrooks P J Vonrhein C | 2006 | Journal of Biological Chemistry2006，281，24： | 1 |
| 16 | The spinning disc reactor: studies on a novel TiO2 photocatalytic reactor 显示文摘 | YATMAZ H C WALLIS C HOWARTH C R | 2001 | Chemosphere2001，42，4： | 1 |
| 17 | Behcet's disease ase and review of the literature显示文摘 | Wallis S Macierewicz J report of a c Med Assoe BM | 2006 | JNMA J Nepal2006，45，164： | 1 |
| 18 | Axillary lymph node metas- tases :a statistical analysis of various parameters in MRI with USPIO显示文摘 | Stets C Brandt S Wallis F | 2002 | J Magn Reson Imaging2002，16，1： | 1 |
| 19 | Probability Weighted Moments Com- pared with Some Traditional Techniques in Estimating Gumbel Parameters and Quantiles 显示文摘 | Landwehr J M Natalas N C Wallis J R | 1979 | Water Resources Research1979，15，5： | 1 |
| 20 | Children on long-term ventilalo,7 support: 10 years of progress 显示文摘 | Wallis C Paton JY Beaton S | 2011 | Arch Dis Child2011，96，11： | 1 |
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