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| 1 | Effect of propranolol on the splanchnic and peripheral renin angiotensin system in cirrhotic patients显示文摘AIM:To evaluate the effect of β-blockade on angiotensins in the splanchnic and peripheral circulation of cirrhotic patients and also to compare hemodynamic parameters during liver transplantation according to propranolol pre-treatment or not. METHODS:Patients were allocated into two groups:outpatients with advanced liver disease(LD) and during liver transplantation(LT). Both groups were subdivided according to treatment with propranolol or not. Plasma was collected through peripheral venipuncture to determine plasma renin activity(PRA),Angiotensin(Ang) Ⅰ,Ang Ⅱ,and Ang-(1-7) levels by radioimmunoassay in LD group. During liver transplantation,hemodynamic parameters were determined and blood samples were obtained from the portal vein to measure renin angiotensin system(RAS) components.RESULTS:PRA,Ang Ⅰ,Ang Ⅱ and Ang-(1-7) were signifi cantly lower in the portal vein and periphery in all subgroups treated with propranolol as compared to non-treated. The relationships between Ang-(1-7) and Ang Ⅰ levels and between Ang Ⅱ and Ang Ⅰ were significantly increased in LD group receiving propranolol. The ratio between Ang-(1-7) and Ang Ⅱ remained unchanged in splanchnic and peripheral circulation in patients under β-blockade,whereas the relationship between Ang Ⅱ and Ang Ⅰ was significantly increased in splanchnic circulation of LT patients treated with propranolol. During liver transplantation,cardiac output and index as well systemic vascular resistance and index were reduced in propranolol-treated subgroup. CONCLUSION:In LD group,propranolol treatment reduced RAS mediators,but did not change the ratio between Ang-(1-7) and Ang Ⅱ in splanchnic and peripheral circulation. Furthermore,the modification of hemodynamic parameters in propranolol treated patients was not associated with changes in the angiotensin ratio. | Walkíria Wingester Vilas-Boas Antnio Ribeiro-Oliveira Jr Renata da Cunha Ribeiro Renata Lúcia Pereira Vieira Jerusa Almeida Ana Paula Nadu Ana Cristina Sim■es e Silva Robson Augusto Souza Santos | 2008 | World Journal of Gastroenterology2008，14，44： | 2 |
| 2 | Possible involvement of abscisic acid of daylily petals显示文摘 | PANAVAS T WALK E L RUBINSTEIN B | 1998 | Journal of Botany1998，49，： | 1 |
| 3 | The usefulness of the detection of GSTP1 methylation in urine as a biomarker in the diagnosis of prostate cancer 显示文摘 | Woodson K O' Reilly K J Hanson J C Nelson D Walk E L Tangrea J A | 2008 | J Urol2008，179，： | 1 |
| 4 | The usefulness of the detection of GSTP1 methylation in urine as a biomarker in the diagnosis of prostate eancer显示文摘 | Woodson K O'Reilly K J Hanson J C Nelson D Walk E L Tangrea J A | 2008 | J Urol2008，179，： | 1 |
| 5 | Diarrhea in tube-fed patients: feeding formula not necessarily the cause显示文摘 | Edes T E Walk B E Austin J L | 1990 | Am J Med1990，88，2： | 1 |
| 6 | The burden of symptoms among community-dwelling older persons with advanced chronic disease 显示文摘 | Walke L M Gallo W T Tinetti M E | 2004 | Arch Intern Med2004，164，21： | 1 |
| 7 | Range and se- verity of symptoms over time among older adults with chronic ob- structive pulmonary disease and heart failure 显示文摘 | WALKE L M BYERS A L TINETTI M E | 2007 | Arch Intern Med2007，167，22： | 1 |
| 8 | Range and severity of symptoms over time among older adults withchronic obstructive pulmonary disease and heart failure 显示文摘 | Walke L M Byers A L Tinetti M E | 2007 | Arch Intern Med2007，167，22： | 1 |
| 9 | Unconventional Rac-GEF activity is mediated through the Dockl80-ELMO complex显示文摘 | Brugnera E Haney L Grimsley C Lu M Walk SF Tosello-Trampont AC | 2002 | Nat Cell Biol2002，4，8： | 1 |
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