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| 1 | Inflammatory processes in the liver: divergent roles in homeostasis and pathology显示文摘The hepatic immune system is designed to tolerate diverse harmless foreign moieties to maintain homeostasis in the healthy liver.Constant priming and regulation ensure that appropriate immune activation occurs when challenged by pathogens and tissue damage.Failure to accurately discriminate,regulate,or effectively resolve inflammation offsets this balance,jeopardizing overall tissue health resulting from an either overly tolerant or an overactive inflammatory response.Compelling scientific and clinical evidence links dysregulated hepatic immune and inflammatory responses upon sterile injury to several pathological conditions in the liver,particularly nonalcoholic steatohepatitis and ischemia-reperfusion injury.Murine and human studies have described interactions between diverse immune repertoires and nonhematopoietic cell populations in both physiological and pathological activities in the liver,although the molecular mechanisms driving these associations are not clearly understood.Here,we review the dynamic roles of inflammatory mediators in responses to sterile injury in the context of homeostasis and disease,the clinical implications of dysregulated hepatic immune activity and therapeutic developments to regulate liver-specific immunity. | Ola Ahmed Mark W.Robinson Cliona O’Farrelly | 2021 | Cellular & Molecular Immunology2021，18，6： | 5 |
| 2 | Peroxiredoxin: a central player in immune modulation显示文摘 | M. W.ROBINSON A. T.HUTCHINSON J. P.DALTON S.DONNELLY | 2010 | Parasite Immunology2010，，5： | 1 |
| 3 | CRELD1 mutations contribute to the occurrence of cardiac atrioventricular septal defects in Down syndrome显示文摘 | Cheryl L.Maslen DarcieBabcock Susan W.Robinson Lora J. H.Bean Kenneth J.Dooley Virginia L.Willour Stephanie L.Sherman | 2006 | Am. J. Med. Genet2006，，： | 1 |
| 4 | The effects of temperature on decomposition and allelopathic phytotoxicity of boneseed litter显示文摘Decomposition of plant litter is a fundamental process in ecosystem function, carbon and nutrient cycling and, by extension, climate change. This study aimed to investigate the role of temperature on the decomposition of water soluble phenolics(WSP), carbon and soil nutrients in conjunction with the phytotoxicity dynamics of Chrysanthemoides monilifera subsp. monilifera(boneseed) litter. Treatments consisted of three factors including decomposition materials(litter alone, litter with soil and soil alone), decomposition periods and temperatures(5–15, 15–25and 25–35°C(night/day)). Leachates were collected on 0, 5, 10, 20, 40 and 60 th days to analyse physico-chemical parameters and phytotoxicity. Water soluble phenolics and dissolved organic carbon(DOC) increased with increasing temperature while nutrients like SO-24 and NO-13 decreased. Speed of germination, hypocotyl and radical length and weight of Lactuca sativa exposed to leachates were decreased with increasing decomposition temperature. All treatment components had significant effects on these parameters. There had a strong correlation between DOC and WSP, and WSP content of the leachates with radical length of test species. This study identified complex interactivity among temperature, WSP, DOC and soil nutrient dynamics of litter occupied soil and that these factors work together to influence phytotoxicity. | Md.Abdullah Yousuf Al Harun Joshua Johnson Md.Nazim Uddin Randall W.Robinson | 2015 | Journal of Environmental Sciences2015，27，7： | 1 |
| 5 | 从排送率看泥浆携带钻屑能力显示文摘为使钻屑输送达到最佳状态,尽管实际中输送率不可能达到100%,但应尽可能使其保持最高。现采用几个经验公式来估算回转钻进中岩屑的滑动速度。由于流动状态的复杂性,利用这些公式不能对复杂的流态计算出精确的结果。 | Mohamed S.Bizanti Steven W.Robinson 郑秀华 胡茂焱 | 1990 | 国外地质勘探技术1990，，6： | 0 |
| 6 | Do phytotoxic allelochemicals remain in ashes after burning Chrysanthemoides monilifera subsp. monilifera(boneseed)?显示文摘Australia is facing challenges in controlling Chrysanthemoides monilifera subsp. monilifera(boneseed). However, burning has achieved some success in this regard. We aimed to investigate the comparative phytotoxicity of boneseed dried powder and ashes(burnt at 450℃ and250℃). Phenolic compounds in powder and ashes were measured using Folin–Ciocalteu assay and HPLC. The phytotoxicity of boneseed powder and ash extracts was assessed through germination bioassay on Lactuca sativa and the phytotoxicity of litter and ashes was evaluated using field soil, both in growth chamber. Burning of boneseed reduced total phenolics in ashes of boneseed organs by 99% and 100% both at high and low temperatures. The four phenolic compounds that were detected in boneseed were either absent or at negligible levels in the ashes,with inversely related to temperature. Both boneseed ash extracts and litter ash-mediated soil significantly reduced phytotoxicity displaying increased germination, biometric and biochemical parameters of test species compared with unburnt powder extracts and litter powder-mediated soil respectively, with greater reduction of phytotoxicity found for ashes produced at the lower temperature. Interestingly, the ash extracts and litter ash-mediated soil were found to stimulate some of those parameters of the test species compared to control. There was no excessive reactive oxygen species(ROS) produced in test species exposed to ash extracts compared with unburnt powder extracts. These findings suggest that burning of boneseed is an appropriate method of weed control and that this approach will reduce phytotoxicity of this species on native plants. | Md.Abdullah Yousuf Al Harun Joshua Johnson Randall W.Robinson | 2016 | Journal of Environmental Sciences2016，28，6： | 0 |
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