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| 1 | Hyaluronic acid facilitates bone repair effects of calcium phosphate cement by accelerating osteogenic expression显示文摘Calcium phosphate cements(CPC)are widely anticipated to be an optimum bone repair substitute due to its satisfied biocompatibility and degradability,suitable to be used in minimally invasive treatment of bone defects.However the clinical application of CPC is still not satisfied by its poor cohesiveness and mechanical properties,in particular its osteoinductivity.Hyaluronic acid reinforced calcium phosphate cements(HA/CPC)showed extroadinary potential not only enhancing the compressive strength of the cements but also significantly increasing its osteoinductivity.In our study,the compressive strength of HA/CPC increased significantly when the cement was added 1%hyaluronic acid(denoted as 1-HA/CPC).In the meantime,hyaluronic acid obviously promoted ALP activity,osteogenic related protein and mRNA expression of hBMSCs(human bone marrow mesenchymal stem cells)in vitro,cement group of HA/CPC with 4%hyaluronic acid adding(denoted as 4-HA/CPC)showed optimal enhancement in hBMSCs differentiation.After being implanted in rat tibial defects,4-HA/CPC group exhibited better bone repair ability and bone growth promoting factors,comparing to pure CPC and 1-HA/CPC groups.The underlying biological mechanism of this stimulation for HA/CPC may be on account of higher osteogenic promoting factors secretion and osteogenic genes expression with hyaluronic acid incorporation.These results indicate that hyaluronic acid is a highly anticipated additive to improve physicochemical properties and osteoinductivity performance of CPCs for minimally invasive healing of bone defects. | Xu Cui Chengcheng Huang Zhizhen Chen Meng Zhang Chunyu Liu Kun Su Jianyun Wang Li Li Renxian Wang Bing Li Dafu Chen Changshun Ruan Deping Wang William W.Lu Haobo Pan | 2021 | Bioactive Materials2021，6，11： | 6 |
| 2 | Strontium modulates osteogenic activity of bone cement composed of bioactive borosilicate glass particles by activating Wnt/β-catenin signaling pathway显示文摘There is a need for synthetic grafts to reconstruct large bone defects using minimal invasive surgery.Our previous study showed that incorporation of Sr into bioactive borate glass cement enhanced the osteogenic capacity in vivo.However,the amount of Sr in the cement to provide an optimal combination of physicochemical properties and capacity to stimulate bone regeneration and the underlying molecular mechanism of this stimulation is yet to be determined.In this study,bone cements composed of bioactive borosilicate glass particles substituted with varying amounts of Sr(0 mol%to 12 mol%SrO)were created and evaluated in vitro and in vivo.The setting time of the cement increased with Sr substitution of the glass.Upon immersion in PBS,the cement degraded and converted more slowly to HA(hydroxyapatite)with increasing Sr substitution.The released Sr2+modulated the proliferation,differentiation,and mineralization of hBMSCs(human bone marrow mesenchymal stem cells)in vitro.Osteogenic characteristics were optimally enhanced with cement(designated BG6Sr)composed of particles substituted with 6mol%SrO.When implanted in rabbit femoral condyle defects,BG6Sr cement supported better peri-implant bone formation and bone-implant contact,comparing to cements substituted with 0mol%or 9mol%SrO.The underlying mechanism is involved in the activation of Wnt/β-catenin signaling pathway in osteogenic differentiation of hBMSCs.These results indicate that BG6Sr cement has a promising combination of physicochemical properties and biological performance for minimally invasive healing of bone defects. | Xu Cui Yadong Zhang Jianyun Wang Chengcheng Huang Yudong Wang Hongsheng Yang Wenlong Liu Ting Wang Deping Wang Guocheng Wang Changshun Ruan Dafu Chen William W.Lu Wenhai Huang Mohamed N.Rahaman Haobo Pan | 2020 | Bioactive Materials2020，5，2： | 3 |
| 3 | Akermanite used as an alkaline biodegradable implants for the treatment of osteoporotic bone defect显示文摘In osteoporosis scenario, tissue response to implants is greatly impaired by the deteriorated boneregeneration microenvironment. In the present study, a Mg-containing akermanite (Ak) ceramic wasemployed for the treatment of osteoporotic bone defect, based on the hypothesis that both beneficialions (e.g. Mg^2+ ect.) released by the implants and the weak alkaline microenvironment pH (μe-pH) itcreated may play distinct roles in recovering the abnormal bone regeneration by stimulating osteoblasticanabolic effects. The performance of Ak, b-tricalcium phosphate (β-TCP) and Hardystone (Har) in healinga 3 mm bone defect on the ovariectomized (OVX) osteoporotic rat model was evaluated. Our resultsindicated that, there's more new bone formed in Ak group than in β-TCP or Har group at week 9. Theinitial me-pHs of Ak were significantly higher than that of the β-TCP and Blank group, and this weakalkaline condition was maintained till at least 9 weeks post-surgery. Increased osteoblastic activity whichwas indicated by higher osteoid secretion was observed in Ak group at week 4 to week 9. An intermediatelayer which was rich in phosphorus minerals and bound directly to the new forming bone wasdeveloped on the surface of Ak. In a summary, our study demonstrates that Ak exhibits a superior boneregenerative performance under osteoporosis condition, and might be a promising candidate for thetreatment of osteoporotic bone defect and fracture. | Wenlong Liu Ting Wang Xiaoli Zhao Xiuli Dan William W.Lu Haobo Pan | 2016 | Bioactive Materials2016，1，2： | 3 |
| 4 | 1.5T多回波IDEAL梯度回波水脂肪分离技术在软骨体积快速诊断中的初步研究显示文摘本研究符合HIPAA要求,经机构审核委员会批准.并获取受试者的知情同意。研究目的是前瞻性对照多回波迭代水脂不对称回波分解与最小二乘估计(IDEAL)梯度回波(GRE)MRI与三维脂肪抑制(FS)扰相GRE(SPGR)MRI两种方法对膝关节软骨的评价。 | C.A.Chen W.Lu B.A.Hargreaves S.B.Reeder G.E.Gold 白荣杰 | 2009 | 国际医学放射学杂志2009，32，5： | 2 |
| 5 | Gold nanoparticles and imaging mass spectrometry:double imaging of latent figerprints显示文摘 | H.W.Tang W.Lu C.M.Che | | 0，，82： | 1 |
| 6 | Approach and applications of constrained ICA显示文摘 | W.Lu J.C.Rajapakse | | 0，，01： | 1 |
| 7 | The internationalization and performance of SMEs显示文摘 | Jane W.Lu Paul W.Beamish | 2001 | Strat Mgmt J (鈥?)2001，，6： | 1 |
| 8 | An Open Baseband Processing Architecture for 4G-OWA Mobile Terminal Design显示文摘This paper introduces an open wireless architecture(OWA) terminal design,focusing on the open baseband processing platform to support different existing and future wireless communication standards through the multi-dimensional open baseband processing modules with open interface parameters and baseband management systems.The paper describes multi-layer open system architecture to maximize the system flexibility and minimize the terminal power consumption,so as to provide an integrated and converged next generation wireless and mobile communication terminal system. | Willie W.Lu | 2007 | China Communications2007，4，2： | 1 |
| 9 | Gold nanoparticles and imaging mass spectrometry:double imaging of latent figerprints显示文摘 | H.W.Tang W.Lu C.M.Che | | 0，，82： | 1 |
| 10 | Challenge in understanding size and shape dependent toxicity of gold nanomaterials in human skin keratinocytes显示文摘 | S.Wang W.Lu O.Tovmachenko U.S.Rai H.Yu P.C.Ray | | 0，，： | 1 |
| 11 | Toward inkjet printing of small molecule organic light emitting diodes显示文摘 | H.Gorter M.J.J.Coenen M.W.L.Slaats M.Ren W.Lu C.J.Kuijpers W.A.Groen | | 0，，： | 1 |
| 12 | Future Mobile Terminal and Network Access Architecture for China 4G Open Mobile Communications显示文摘This paper relates to an advanced open mobile communication system and method of integrating the mobile communications, wireless access systems and wired communications into one common platform architecture for China's 4th generation mobile communications, supporting costeffective broadband voice, data and video services in wireless, mobile and wired environment with one single integrated mobile terminal device. The paper includes new architecture in the integrated mobile device and converged network access, and minimum modifi cation in the existing mobile telecommunication infrastructures. This paper introduces the long-term evolution strategy for China's TDD system platform towards China's future 4G mobile communications. | Willie W.Lu | 2009 | China Communications2009，6，2： | 1 |
| 13 | Corrigendum to“Strontium modulates osteogenic activity of bone cement composed of bioactive borosilicate glass particles by activating Wnt/β-catenin signaling pathway”[Bioact.Mater.5(2020)334-347]显示文摘The authors regret that the printed version of the above article contained a number of errors which were not identified during the proofing stage.The correct and final version follows.The authors would like to apologies for any inconvenience caused.The authors regret:1.“…and the underlying molecular mechanism of this simulation is yet to be determined”,Page 335,needs to be corrected to“and the underlying molecular mechanism of this stimulation is yet to be determined”. | Xu Cui Yadong Zhang Jianyun Wang Chengcheng Huang Yudong Wang Hongsheng Yang Wenlong Liu Ting Wang Deping Wang Guocheng Wang Changshun Ruan Dafu Chen William W.Lu Wenhai Huang Mohamed N.Rahaman Haobo Pan | 2021 | Bioactive Materials2021，6，8： | 0 |
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