|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 2 | Tuberculosis of the pancreas:case report显示文摘 | Riemann JF Stadler W | 1981 | Endoscopy1981，13，： | 1 |
| 3 | S3-Leitlinie ?Kolorektales Karzinom” – Aktualisierung 2008显示文摘 | W Schmiegel A Reinacher-Schick D Arnold U Graeven V Heinemann R Porschen J Riemann C R?del R Sauer M Wieser W Schmitt H.-J Schmoll T Seufferlein I Kopp C Pox | 2008 | Z Gastroenterol2008，，08： | 1 |
| 4 | Histamine release in dogs by Cremophor EL and its derivatives: oxyethylated oleic acid is the most effective constituent显示文摘 | Lorenz W Riemann HJ Schmal A | 1977 | Agents Actions1977，7，： | 1 |
| 5 | Nanodissection of Human Chromosomes with Near-infrared Femtosecond Laser Pulses 显示文摘 | K KONIG W RIEMANN W FRITZSCHE | 2001 | Optics Letters2001，26，11： | 1 |
| 6 | Rela- tionship between clinical and forceplate measures of postural stability显示文摘 | RIEMANN B L GUSKIEWICZ K M SHIELDS E W | 1999 | J Sport Rehabil1999，8，2： | 1 |
| 7 | Self-assembly and conformation of tetrapyridyl -porphyrin molecules on Ag(111)显示文摘 | Auwarter W Weber-Bargioni A Riemann A et aI | 2006 | J Chern Phys2006，124，19： | 1 |
| 8 | Nanodissection of Human Chromosomes with Near-infrared Femtosecond Laser Pulses显示文摘 | K KONIG I RIEMANN W FRITZSCHE | 2001 | Optics Letters2001，26，11： | 1 |
| 9 | The finest ructure of colonic submuco sal nerves in patients with chronic laxative abuselScand 显示文摘 | Riemann JF Schm idt H Zimmermann W | 1980 | J Gastroenterol1980，15，： | 1 |
| 10 | Histamine release in dogs by eremophor EL and its derivatives : oxyethylated oleie acid is the most effective constituent显示文摘 | Lorenz W Riemann H J Sehmal A | 1977 | Agents Actions1977，7，1： | 1 |
| 11 | Heritability of facet - level traits in a cross -cultural twin sample: Support for a hierarchical model of personality 显示文摘 | Jang K L McCrae R R Angleitner A Riemann R Livesley W J | 1998 | Journal of Personality and Social Psy- chology1998，，74： | 1 |
| 12 | Nanodissection of human chromosomes with near-infrared femtosecond laser puls- es显示文摘 | Riemann I Fritzsche W | 2001 | Opt Lett2001，26，11： | 1 |
| 13 | Tuberculosis of the pancreas显示文摘 | Stock KP Riemann J F Stadler W | 1981 | Endoscopy1981，13，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员