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| 1 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 2 | 在裸鼠体内建立血管瘤模型显示文摘血管瘤是儿童最常见的良性肿瘤,大部分可自发消退,但其发病及消退机制仍不清楚。本文旨在建立人类血管瘤动物模型,为血管瘤发病机制及药物治疗的研究提供基础。方法:取6个月大儿童的血管瘤组织,证实肿瘤细胞雌激素受体阳性后,将肿瘤切成薄片,接种到16只裸鼠皮下,并随机分为2组,对照组给予正常进食,实验组在进食同时给予雌二醇.每周测量移植物的大小。实验小鼠在术后90d处死. | Peng Q Liu W Tang Y | 2005 | 中国口腔颌面外科杂志2005，3，3： | 12 |
| 3 | Metal exposure and Alzheimer's pathogenesis.显示文摘 | Liu G Huang W Moir RD Vanderburg CR Lai B Peng Z Tanzi RE Rogers JT Huang X | 2006 | 中国生物学文摘2006，20，9： | 8 |
| 4 | Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis显示文摘The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types.Although a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely understood.Here,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive microenvironment.Using an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)cells.Depletion of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,respectively.Mechanistically,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic mice.Accordingly,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation donors.In summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic immunosurveillance.Our findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention. | Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 5 | Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial显示文摘 | Craig S Anderson Yining Huang Ji Guang Wang Hisatomi Arima Bruce Neal Bin Peng Emma Heeley Christian Skulina Mark W Parsons Jong Sung Kim Qing Ling Tao Yue Chun Li Jian Dong Jiang Li Wen Tai Jin Li Zhang En Xu Yan Cheng Stephane Heritier Lewis B Morgenste | 2008 | Lancet Neurology2008，，5： | 4 |
| 6 | Intense single-band red upconversion emission in BiOCl:Er3+ layered semiconductor via co-doping Ho3+显示文摘Exploring a new tuning way to facilely realize single-band red emission in trivalent rare-earth ions(RE3+) doped upconversion(UC) materials is still desirable.In this work,the intense single-band red emission is achieved by co-doping only Ho3+in the BiOCl:Er3+ under 1550 nm excitation.In the BiOCl layered host,co-doping Ho3+can further enhance the red emission and simultaneously suppress the green emission of Er3+,and thus obviously improve the red-to-green(R/G) ratio.It is found that Ho3+does not se rve as ene rgy trapping through the 5 I6 state as in traditional UC materials but acts as ET bridge(4 S3/2,2 H11/2(Er3+)→5 F4,5 S2(Ho3+)→4 F9/2(Er3+)).The tuning mechanism of Ho3+is discussed in detail and further confirms through a comparative experiment.Our research gives an unusual perspective to tune the UC behavior of Er3+through co-doping Ho3+,which might be inspiring for achievement of single-band red UC emission. | Yuehong Peng Jincai Peng Jiajun Han Tianhui Wang Zhaoyi Yin Jianbei Qiu Qi W ang Zhengwen Yang Zhiguo Song | 2020 | Journal of Rare Earths2020，38，6： | 2 |
| 7 | Plant tissue-based chemiluminescence flow biosensor for urea显示文摘 | Qin W Zhang Z J Peng Y Y | 2000 | Anal Chim Acta2000，407，12： | 2 |
| 8 | Tetrapod -shaped ZnO whisker and its composites 显示文摘 | ZHOU Z PENG W KE S | 1999 | J Materials Processing Technology1999，8990，： | 2 |
| 9 | The physicochemie, al and functional properties of soybean 11S globulin-a review 显示文摘 | Peng I C Quass D W Dayton W R | 1984 | Cereal Chemistry1984，61，6： | 1 |
| 10 | High alpha-fetoprotein level correlates with high stage, early recurrence and poor prognosis of hepatocellular carcinoma : significance of hepatitis virus infection ,age ,p53 ,and beta-catenin mutations显示文摘 | PENG S Y CHEN W J LAI P L | 2004 | Int J Cancer2004，112，1： | 1 |
| 11 | Astrocyte-mediated control of cerebral blood flow 显示文摘 | Takano T Tian G F Peng W | 2006 | Nat Neurosci2006，9，2： | 1 |
| 12 | The global carbon cycle 显示文摘 | PENG T-H EMANUEL W R | 1990 | Am Sci1990，78，： | 1 |
| 13 | Regeneration of high-performance activated carbon from spent catalyst: Optimization using response surface methodology 显示文摘 | ZHANG Z Y PENG J H QU W W | 2009 | Journal of the Taiwan Institute of Chemical Engineers2009，，40： | 1 |
| 14 | The pathogenesis and clinical significance of a high-intensity zone(HIZ)of lumbar intervertebral disc on MR imaging in the patient with discogenic low back pain显示文摘 | Peng B Hou S Wu W | 2006 | Eur Spine2006，15，5： | 1 |
| 15 | Studies on 6,6￠-di-substituted Effects of the dpq in2+ with DFT method显示文摘 | ZHENG K C WANG J P PENG W L | 2001 | J Phys Chem A2001，105，10： | 1 |
| 16 | 显示文摘 | Wang Y Y Peng W J Chai L Y | 2004 | J Cent Southuniv Technol2004，11，4： | 1 |
| 17 | Experimental study on burning rates of square/rectangular gasoline and methanol pool fires under longitudinal air flow in a wind tunnel显示文摘 | HU L H LIU S PENG W | 2009 | Journal of Hazardous Materials2009，169，： | 1 |
| 18 | Treatment of brewery wastewater using anaerobic sequencing batch reactor 显示文摘 | SHAO X W PENG D C TENG Z H | 2008 | Bioresource Technology2008，99，： | 1 |
| 19 | Tissue distribution and maternal transfer of poly-and perfluorinated compounds in Chinese sturgeon (Acipenser sinensis) : implications for reproductive risk 显示文摘 | Peng H Wei Q W Wan Y | 2010 | Environ Sci Technol2010，44，5： | 1 |
| 20 | An Institution-based View of International Business Strategy: A Focus on Emerging Eeonomies显示文摘 | PENG M W WANG D YL JIANG Y | 2008 | Journal of International Business Studies2008，39，5： | 1 |
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