|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pentadecapeptide BPC 157 resolves suprahepatic occlusion of the inferior caval vein, Budd-Chiari syndrome model in ratsPentadecapeptide BPC 157 resolves suprahepatic occlusion of the inferior caval vein, Budd-Chiari syndrome model in rats显示文摘BACKGROUND Recently,as a possible therapy resolving solution,pentadecapeptide BPC 157 therapy,has been used in alleviating various vascular occlusion disturbances.BPC 157 was previously reviewed as novel mediator of Robert cytoprotection and endothelium protection in the stomach,and gut-brain axis,beneficial therapy in gastrointestinal tract,with particular reference to vascular recruitment,ulcerative colitis and tumor cachexia,and other tissues healing.Here we raised new hypothesis about BPC 157 therapy in the Budd-Chiari syndrome in rats,rapid bypassing of the suprahepatic inferior caval vein occlusion,and rats recovery with the active and effective pharmacotherapy treatment.AIM To investigate Budd-Chiari syndrome model(inferior caval vein suprahepatic occlusion)resolution,since BPC 157 resolves various rat vascular occlusion.METHODS We assessed the activated bypassing pathways between the inferior and superior caval veins and portocaval shunt,counteracted caval/portal hypertension,aortal hypotension,venous/arterial thrombosis,electrocardiogram disturbances,liver and gastrointestinal lesions(i.e.,stomach and duodenum hemorrhages,in particular,congestion).Rats with suprahepatic occlusion of the inferior vena cava by ligation were medicated at 1 min,15 min,24 h,or 48 h post-ligation.Medication consisted of 10μg/kg BPC 157,10 ng BPC 157 or 5 m L/kg saline,administered once as an abdominal bath or intragastric application.Gross and microscopic observations were made,in addition to assessments of electrical activity of the heart(electrocardiogram),portal and caval hypertension,aortal hypotension,thrombosis,hepatomegaly,splenomegaly and venography.Furthermore,levels of nitric oxide,malondialdehyde in the liver and serum enzymes were determined.RESULTS BPC 157 counteracted increased P wave amplitude,tachycardia and ST-elevation,i.e.,right heart failure from acute thrombotic coronary occlusion.The bypassing pathway of the inferior vena cava-azygos(hemiazygos)vein-superior vena cava and portocaval shunt occurred rapidly.Even with severe caval portal hypertension,BPC 157 antagonized portal and caval hypertension and aortal hypotension,and also reduced refractory ascites.Thrombosis of portal vein tributaries,inferior vena cava,and hepatic and coronary arteries was attenuated.In addition,there was reduced pathology of the lungs(severe capillary congestion)and liver(dilated central veins and terminal portal venules),decreased intestine hemorrhagic lesions(substantial capillary congestion,submucosal edema and architecture loss),and increased liver and spleen weight.During the period of ligation,nitric oxide-and malondialdehyde-levels in the liver remained within normal healthy values,and increases in serum enzymes were markedly reduced.CONCLUSION BPC 157 counteracts Budd Chiari syndrome in rats. | Slaven Gojkovic Ivan Krezic Borna Vrdoljak Dominik Malekinusic Ivan Barisic andreja Petrovic Katarina Horvat Pavlov Marijan Kolovrat Antonija Duzel Mario Knezevic Katarina Kasnik Kovac Domagoj Drmic Lovorka Batelja Vuletic Antonio Kokot Alenka Boban Blagaic Sven Seiwerth Predrag Sikiric | 2020 | World Journal of Gastrointestinal Pathophysiology2020，11，1： | 2 |
| 2 | Lipoprotein lipase and phospholipid transfer protein overexpression in human glioma cells and their effect on cell growth, apoptosis, and migration显示文摘Glioma 是在大脑的普通肿瘤之一。脂蛋白脂肪分解酵素(LPL ) 或 phospholipid 转移蛋白质(PLTP ) 的表示水平可以影响有临床、病理学的参数的 glioma 前进和它的关系。在 glioma 的 LPL 或 PLTP 表示的临床的意义没被建立。在现在的学习,在 glioma 肿瘤的 LPL 和 PLTP 层次被调查,在 LPL 和 PLTP 水平和恶意的 glioma 的等级之间的关系被分析,与提供为在临床、基本的研究背景的 gliomas 的诊断和治疗的新想法的目的。LPL 和 PLTP mRNA 和蛋白质层次比在更低的等级肿瘤的那些在等级 IV glioma 是显著地更高的(P P = 0.005 ) 。LPL 和 PLTP 的层次与 glioma 病人的弄短的幸存被增加(P LPL 和 PLTP 导致了减少的房间生长和移植,但是在 vitro 增加了 apoptosis。另外,当 cyclin 依赖的 kinase 禁止者 p16, p21,和 Rb 是起来调整的时,周期相关的 cyclins 和他们的搭挡被发现下面调整的房间。而且, LPL 或 PLTP 击倒导致了 pro-apoptotic 分子的起来规定和 anti-apoptotic 分子的下面规定。在 U251 房间的 LPL 或 PLTP 的脱离导致了上皮的间充质的转变标记和侵略分子矩阵 metalloproteinases 的下面规定。LPL 和 PLTP 看起来是新奇联系 glioma 的蛋白质并且在人的 glioma 的前进起一个作用。 | Weijiang Dong Huilin Gong Guanjun Zhang Simona Vuletic John Albers Jiaojiao Zhang Hua Liang Yanxia Sui Jin Zheng | 2017 | Acta Biochimica et Biophysica Sinica2017，49，1： | 2 |
| 3 | Sensitive Detection of Cold Cesium Molecules Formed on Feshbach Resonances显示文摘 | CHIN C VULETIC V KERMAN A J | 2003 | Phys Rev Lett2003，90，03： | 1 |
| 4 | Knowl-edge of stroke risk factors and warning signs among adults in Slavonsi brod region显示文摘 | Vuletic V Bosnar-Puretic M Lovrencic-Huzjan A | 2006 | Acta Clinica Croatica2006，45，10： | 1 |
| 5 | Widespread distribution of PLTP in human CNS: evidence for PLTP synthesis by glia and neurons, and increased levels in Alzheimer's disease 显示文摘 | VULETIC S JIN L W MARCOVINA S M | 2003 | J Lipid Res2003，44，6： | 1 |
| 6 | CD69 on CD56 + NK cells and response to chemoimmunotherapy in metastatic melanoma显示文摘 | Konjevic G Jovic V Vuletic A | 2007 | Eur J Clin Invest2007，37，11： | 1 |
| 7 | What makes quality of life:Study on croatian ur- ban population 显示文摘 | Vuletic G Mujkic A | 2002 | Lijecnicki Vjesnik2002，124，2： | 1 |
| 8 | In vitro in- creased natural killer cell activity of metastatic melanoma patients with interferon-alpha alone as opposed to its combination with 13- cis retinoic acid is associated with modulation of NKG2D and CD161 activating receptor expression显示文摘 | Konjevic G Mirjacic-Martinovic K Vuletic A | 2012 | J BUON2012，17，4： | 1 |
| 9 | Novel aspects of in vitro IL-2 or IFN-a enhanced NK cytotoxicity of healthy individuals based on NKG2D and CD161 NK cell receptor induction显示文摘 | Konjevic G Mirjacic-Martinovic K Vuletic A | 2010 | Biomed Pharmacother2010，64，10： | 1 |
| 10 | Evaluation of recombinant human interferon alpha-2b structure and stability by ingel tryptic digestion, H/D exchange and mass spectrometry显示文摘 | Cindric M Galic N Vuletic M | 2006 | J Pharm Biomed Anal2006，40，3： | 1 |
| 11 | Cell-associated and extracellular phospholipids transfer protein in human coronary atherosclerosis显示文摘 | O'BRIEN K D VULETIC S MCDONALD T O | 2003 | Circulation2003，108，3： | 1 |
| 12 | Beyond Optical Molasses:3D Raman Sideband Cooling of Atomic Cesium to High Phase-Space Density显示文摘 | KERMAN A J VULETIC V CHEN C | 2000 | Phys Rev Lett2000，84，： | 1 |
| 13 | Oxidative stress in rheumatoid arthritis patients: relationship to diseases activity显示文摘 | VESELINOVIC M BARUDZIC N VULETIC M | 2014 | Mol Cell Biochem2014，34，9： | 1 |
| 14 | Seamless Hardware-software Integration in Reconfigurable Computing Systems显示文摘 | Vuletic M Pozzi L Ienne P | | 0，，02： | 1 |
| 15 | High-dose epirubicin-cisplantin chemotherapy for advanced soft tissue sarcoma 显示文摘 | Jelic S Vuletic L Milanovic N | 1990 | Tumori1990，76，： | 1 |
| 16 | yon Willebrand factor and oxidative stress parameters in acute coronary syndromes 显示文摘 | Koprivica Z Djordjevic D Vuletic M | 2011 | Oxid Med Cell Longer2011，8，： | 1 |
| 17 | Effect of in- domethacin on cerebrovascular reactivity in patients with type 2 diabetes mellitus 显示文摘 | Vuletic V Drenjancevic I Rahelic D | 2013 | Diabetes Res Clin Pract2013，101，1： | 1 |
| 18 | The spin-ladder and spin-chain system ( La, Y, Sr, Ca)14 Cu24 O41 electronic phases, charge and spin dynamics 显示文摘 | Vuletic T Korin-Hamzic B Ivek K Tomic S Gorshunov B Dressel M Akimitsu J | 2006 | Physics Reports2006，428，： | 1 |
| 19 | Phonetic metaphor 显示文摘 | VULETIC B | 2003 | Russian Literature LIV2003，，： | 1 |
| 20 | Oxidative stress in rheumatoid arthritis patients: relationship to diseases aetivity显示文摘 | Veselinovic M Barudzic N Vuletic M | 2014 | Mol Cell Biochem2014，391，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员