|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Chronic hepatitis C virus infection:Prevalence of extrahepatic manifestations and association with cryoglobulinemia in Bulgarian patients显示文摘AIM: To assess the prevalence of extrahepatic manifestations in Bulgarian patients with chronic hepatitis C virus (HCV) infection and identify the clinical and biological manifestations associated with cryoglobulinemia. METHODS: The medical records of 136 chronically infected HCV patients were reviewed to assess the prevalence of extrahepatic manifestations. Association between cryoglobulin-positivity and other manifestations were identified using χ2 and Fisher’s exact test. Risk factors for the presence of extrahepatic manifestations were assessed by logistic regression analysis. RESULTS: Seventy six percent (104/136) of the patients had at least one extrahepatic manifestation. Clinical manifestations included fatigue (59.6%), kidney impairment (25.0%), type 2 diabetes (22.8%), paresthesia (19.9%), arthralgia (18.4%), palpable purpura (17.6%), lymphadenopathy (16.2%), pulmonary fi brosis (15.4%), thyroid dysfunction (14.7%), Raynaud’s phenomenon (11.8%), B-cell lymphoma (8.8%), sicca syndrome (6.6%), and lichen planus (5.9%). The biological manifestations included cryoglobulinproduction (37.5%), thrombocytopenia (31.6%), and autoantibodies: anti-nuclear (18.4%), anti-smooth muscle (16.9%), anti-neutrophil cytoplasm (13.2%) and anti-cardiolipin (8.8%). All extrahepatic manifestations showed an association with cryoglobulin-positivity, with the exception of thyroid dysfunction, sicca syndrome, and lichen planus. Risks factors for the presence of extrahepatic manifestations (univariate analysis) were: age ≥ 60 years, female gender, virus transmission by blood transfusions, longstanding infection (≥ 20 years), and extensive liver fi brosis. The most signifi cant risks factors (multivariate analysis) were longstanding infection and extensive liver fi brosis. CONCLUSION: We observed a high prevalence of extrahepatic manifestations in patients with chronic HCV infection. Most of these manifestations were associated with impaired lymphoproliferation and cryoglobulin production. Longstanding infection and extensive liver fi brosis were signifi cant risk factors for the presence of extrahepatic manifestations in HCV patients. | Diana V Stefanova-Petrova Anelia H Tzvetanska Elisaveta J Naumova Anastasia P Mihailova Evgenii A Hadjiev Rumiana P Dikova Mircho I Vukov Konstantin G Tchernev | 2007 | World Journal of Gastroenterology2007，13，48： | 5 |
| 2 | Pain and ischemic symptoms in craniocervical artery dissection显示文摘 | Lovrencic-Huzjan A Vukovic V Azman D | 2008 | Acta Med Croatica2008，62，： | 1 |
| 3 | Transcranial Doppler in brain death confirmation in clinical practice显示文摘 | Lovrencic-Huzjan A Vukovic V Gopcevic A | | 0，，01： | 1 |
| 4 | Removal of cadmium from aqueous solutions by oxidized and ethylenediaminefunctionalized multi-walled carbon nanotubes显示文摘 | Vukovic G D Marinkovic A D Colic M | 2010 | Chem Eng J2010，157，： | 1 |
| 5 | Chemoendocrine therapy for premenopausal women with axillary lymph node-positive,steroid hormone receptor-positive breast cancer:results from INT 0101 (E5188)显示文摘 | Davidson N E O'Neill A M Vukov A M | 2005 | J Clin Oncol2005，23，25： | 1 |
| 6 | Animal models of depression显示文摘 | Damjanovic A Petrovic M Vukovic T | 2000 | Vojnosanit Pregl2000，57，6： | 1 |
| 7 | Endoplasmic reticu- lurn stress is involved in the response of human laryngeal carcinoma cells to Carboplatin but is absent in Carboplatin-resistant cells 显示文摘 | Brozovie A Vukovic L Polancae DS | 2013 | PLoS One2013，8，76： | 1 |
| 8 | Evolutionary prisoner's dilemma game on Newman-Watts networks 显示文摘 | Vukov J Szabo G Szolnoki A | 2008 | Physical Review E2008，77，26： | 1 |
| 9 | Nitrate removal from ground water and denitrification rates in a porous treatment wall amended with sawdust显示文摘 | Louis A Schipper M Vojvodic - Vukovic | 2000 | Ecological Engineering2000，14，： | 1 |
| 10 | The response of peritoneal macrophages to dapsone cova- lently attached on the surface of carbon nanotubes显示文摘 | Vukovic G D Tomic S Z Marinkovic A D | 2010 | Carbon2010，48，11： | 1 |
| 11 | Cooperation in the noisy case:prisoner's dilemma game on two types of regular random graphs显示文摘 | Szabo G Szolnoki A | 2006 | Physical Review E2006，73，06： | 1 |
| 12 | Protection from radiation-induced DNA slngle-strand breaksbyinduction of nuclear metallothinoein显示文摘 | Vukovic V Pheng Say-Ry Stewart A Vik C Hedley D W | 2000 | International Joural of Radiation Biology2000，76，6： | 1 |
| 13 | Maximum rates of nitrate removal in a denitrification wall显示文摘 | Schipper L A Barkle G F Vojvodic -Vukovic M | 2005 | Journal of Environ- mental Quality2005，34，4： | 1 |
| 14 | Testing of AGARD- B calibration model in the T 38 transonic wind tunnel显示文摘 | Damljanovi D Vitic A Vukovic D | 2006 | Scientific-Technical Review2006，，2： | 1 |
| 15 | Five years of nitrate removal,denitrification and carbon dynamics in a denitrificationwall显示文摘 | Schipper L A Vojvodic′-Vukovic′M | 2001 | Water Research2001，35，14： | 1 |
| 16 | Testing of AGARD-B Calibration Model in the T-38 Transonic Wind Tunnel 显示文摘 | Damljanovic D Vitic A Vukovic D | 2006 | Scientific Technical Review2006，，2： | 1 |
| 17 | Use of electron-beam computed tomography in the evaluation of chest pain patients in the emergency department显示文摘 | LAUDON D A VUKOV L F BREEN J F | 1999 | Ann Emerg Med1999，33，1： | 1 |
| 18 | Phase diagrams for an evolutionary prisonerrs dilemma game on two-dimensional lattices 显示文摘 | Szab6 G Vukov J Szolnoki A | 2005 | Physical Review E2005，72，04： | 1 |
| 19 | Cooperation in the noisy case: Prisoner's dilemma game on two types of regular random graphs 显示文摘 | Vukov J Szabb G Szolnoki A | 2006 | Physical Review E2006，73，06： | 1 |
| 20 | Effect of chemohomonal therapy in premenopausal, node ( + ), receptor ( + )breast cancer: an Eastern cooperative oncology group phase Ⅲ intergroup trial (E5188, INT-0101) 显示文摘 | O' Neill A Vukov A | 1999 | ProASCO1999，249，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员