维普期刊资源整合服务平台（V6.5）

维普中文期刊产品整合服务

9篇 您的检索式：作者名="Vrang L"

选中清除导出查看参考文献查看引证文献引用追踪共1页首页上一页第1页下一页末页 /1 跳转

		题名	作者	年代	出处	被引量
	1	Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments.	Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen	2019	World Journal of Gastroenterology2019，25，33：	3
	2	Anti-HIV type 1 activity of 3'-fluoro-3'-deoxythymidine for several different multidrug- resistant mutants显示文摘	Kim EY Vrang L Oberg B	2001	AIDS Res Hum Retroviruses2001，17，5：	1
	3	The effects of 13 wkof liraglutide treatment on endocrine and exocrine pancreasin male and female ZDF rats: a quantitative and qualitativeanalysis revealing no evidence of drug-induced pancreatitis显示文摘	Vrang N Jelsing J Simonsen L	2012	Am J Physiol Endocrinol Metab2012，303，2：	1
	4	Characterization of a set of HIV-1 protease inhibitors using binding kinetics data from a biosensor-based screen显示文摘	Hamalainen M D Markgren P O Schaal W Karlen A Classon B Vrang L	2000	J Biomol Screen2000，5，：	1
	5	The effects of 13 wk ofliraglutide treatment on endocrine and exocrine pancreas in maleand female ZDF rats : a quantitative and qualitative analysis re-vealing no evidence of drug-induced pancreatitis 显示文摘	Vrang N Jelsing J Simonsen L	2012	Am JPhysiol Endocrinol Metab2012，303，2：	1
	6	Improved structure-activity relationship analysis of HIV-I protease inhibitors using interaction kinetic data 显示文摘	Shuman C F Vrang L Danielson U H	2004	J Med Chem2004，47，24：	1
	7	Anti-HIV type 1 activity of 30-fluoro-30-deoxythymidine for several different multidrug resistant mutants显示文摘	Kim EY Vrang L Oberg B	2001	AIDS Res Hum Retroviruses2001，17，5：	1
	8	The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss显示文摘	Secher Anna Jelsing Jacob Baquero Arian F Hecksher-S?rensen Jacob Cowley Michael A Dalb?ge Louise S Hansen Gitte Grove Kevin L Pyke Charles Raun Kirsten Sch?ffer Lauge Tang-Christensen Mads Verma Saurabh Witgen Brent M Vrang Niels Knudsen	2014	Journal of Clinical Investigation2014，，10：	1
	9	The effects of 13 weeks of liraglutide treatment on endocrine and exocrine pancreas in male and female ZDF rats:no evidence of drug induced pancreatitis显示文摘	Vrang N Jelsing J Simonsen L		0，，02：	1

返回顶部每页显示：

共1页首页上一页第1页下一页末页 /1 跳转

goolge学术搜索-维普

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费