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2篇 您的检索式:作者名="Voudoukis E"
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1Multipotent role of platelets in inflammatory bowel diseases:A clinical approach显示文摘There is evidence that inflammatory bowel diseases(IBD)combine both inflammation and coagulation in their pathogenesis and clinical manifestations.Although platelets(PLT)are well known for their role in hemo stasis,there are a rising number of studies supporting their considerable role as inflammatory amplifiers in chronic inflammatory conditions.IBD are associated with several alterations of PLT,including number shape,and function,and these abnormalities are main ly attributed to the highly activated state of circulating PLT in IBD patients.When PLT activate,they increase in size,release a great variety of bio-active inflamma tory and procoagulant molecules/particles,and express a variety of inflammatory receptors.These inflamma tory products may represent a part of the missing link between coagulation and inflammation,and can be considered as possible IBD pathogenesis instigators.In clinical practice,thrombocytosis is associated both with disease activity and iron deficiency anemia.Controlling inflammation and iron replacement in anemic patient usually leads to a normalization of PLT count.The aim of this review is to update the role of PLT in IBD and present recent data revealing the possible therapeutic implications of anti-PLT agents in future IBD remedies.Evangelos Voudoukis Konstantinos Karmiris Ioannis E Koutroubakis 2014World Journal of Gastroenterology2014,20,12:27
2Associa- tion between thrombocytosis and iron deficiency anemia in in- flammatory bowel disease 显示文摘Voudoukis E Karmiris K Oustamanolakis P 2013Eur J Gastroenterol Hepatol2013,25,10:1
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