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| 1 | H pylori and gastric cancer: Shifting the global burden显示文摘Infection with H pylori leads to a persistent chronic in?ammation of the gastric mucosa, thereby increasing the risk of distal gastric adenocarcinoma. Numerous studies have determined a clear correlation between H pylori infection and the risk of gastric cancer; however, general eradication is not recommended as cancer prophylaxis and time points for treatment remain controversial in different areas of the world. Prevalence rates in Western countries are decreasing, especially in younger people (< 10%); and a decline in distal gastric adenocarcinoma has been observed. Risk groups in Western countries still show considerably higher risk of developing cancer, especially in patients infected with cagA + strains and in persons harboring genetic polymorphism of the IL-1B promoter (-511T/T) and the corresponding IL-1 receptor antagonist (IL-1RN*2). Thus, general eradication of all infected persons in Western countries not recommended and is limited to risk groups in order to achieve a risk reduction. In contrast, infection rates and cancer prevalence are still high in East Asian countries. A prevention strategy to treat infected persons may avoid the development of gastric cancer to a large extent and with enormous clinical importance. However, studies in China and Japan indicate that prevention of gastric cancer is effective only in those patients that do not display severe histological changes such as atrophy and intestinal metaplasia. Thus, prophylactic strategies to prevent gastric cancer in high risk populations such as China should therefore especially aim at individuals now at younger age when the histological alterations caused by the bacterial infection was still reversible. In countries with a low prevalence of gastric cancer, risk groups carrying cagA+ strains and IL-1 genetic polymorphisms should be identi?ed and treated. | Christian Prinz Susanne Schwendy Petra Voland | 2006 | World Journal of Gastroenterology2006，12，34： | 33 |
| 2 | In vitro activity of moxifloxacin and piperacillin/sulbactam against pathogens of acute cholangitis显示文摘AIM: To analyze the in vitro activity of moxifloxacin and piperacillin/sulbactam against pathogens isolated from patients with acute cholangitis. METHODS: In this prospective study a total of 65 patients with acute cholangitis due to biliary stone obstruction (n = 7), benign biliary stricture (n = 16), and malignant biliary stricture (n = 42) were investigated with regard to spectrum of bacterial infection and antibiotic resistance. Pathogens were isolated from bile cultures in all study patients. In 22 febrile patients, blood cultures were also obtained. In vitro activity of moxifloxacin and piperacillin/ sulbactam was determined by agar diffusion. RESULTS: Thirty-one out of 65 patients had positive bile and/or blood cultures. In 31 patients, 63 isolates with 17 different species were identified. The predominant strains were Enterococcus species (26/63), E.coli (13/63) and Klebsiella species (8/63). A comparable in vitro activity of moxifloxacin and piperacillin/sulbactam was observed for E.coli and Klebsiella species. In contrast, Enterococcus species had higher resistances towards moxifloxacin. Overall bacteria showed antibiotic resistances in vitro of 34.9% for piperacillin/sulbactam and 36.5% for moxifloxacin.CONCLUSION: Enterococcus species , E.coli and Klebsiella species were the most common bacteria isolated from bile and/or blood from patients with acute cholangitis. Overall, a mixed infection with several species was observed, and bacteria showed a comparable in vitro activity for piperacillin/sulbactam and moxifloxacin. | Andreas Weber Wolfgang Huber Klaus Kamereck Philipp Winkle Petra Voland Hans Weidenbach Roland M Schmid Christian Prinz | 2008 | World Journal of Gastroenterology2008，14，20： | 18 |
| 3 | Human dendritic cells respond to Helicobacter pylori,promoting NK cell and Th1-effector responses in vitro显示文摘 | Hafsi N Voland P Schwendy S | 2004 | J Immunol2004，173，2： | 1 |
| 4 | X-43A hypersonic vehicle technology development显示文摘 | Voland R T Huebner L D Mcclinton C R | 2006 | Acta Astronautica2006，59，1： | 1 |
| 5 | Antigenic Properties ofHpaA and Omp18,two outer membrane proteins of Helicobact-er pylori显示文摘 | Voland P Hafsi N Zeitner M | 2003 | Infection and Immunity2003，71，7： | 1 |
| 6 | Cellular steady-state levels of 'high risk' but not 'low risk' human papillomavirus (HPV)E6 pro- Leins are increased by inhibition of proteasome-dependent degrada- Lion independent of their p53- and E6AP-binding capabilities 显示文摘 | Kehmeier E Rtihl H Voland B | 2002 | Virology2002，299，1： | 1 |
| 7 | X-43A hyper- sonic vehicle technology development 显示文摘 | VOLAND R T HUEBNER L D MCCLINTON C R | 2006 | Acta Astronautica2006，59，1： | 1 |
| 8 | X-43A Hypersonic vehicle technology development 显示文摘 | Voland R T Huebner L D McClinton C R | 2006 | Acta Astronautica2006，59，： | 1 |
| 9 | Video decision support tool for advance care planning in dementia:randomised controlled trial显示文摘 | Volandes AE Paasche-Odow MK Barry MJ | 2009 | BMJ2009，28，： | 1 |
| 10 | Vascular endothelial growth factors, angiogenesis, and survival in human ileal enterochromaffin cell carcinoids 显示文摘 | Besig S Voland P | 2009 | Neuroendocrinology2009，90，4： | 1 |
| 11 | Repression of cell cycle-related proteins by oxaliplatin but not Cisplatin in human colon cancer cells显示文摘 | Voland C Bord A Peleraux A | 2006 | Mol Cancer Ther2006，5，9： | 1 |
| 12 | A secreted low- molecular weight protein from Helicobacter pylori induces cell-cycle arrest of T ceils 显示文摘 | Gerhard M Schmees C Voland P | 2005 | Gastroenterology2005，128，5： | 1 |
| 13 | Repression of cell cycle-related proteins by oxaliplatin but not cisplatin in human colon cancer cells显示文摘 | Voland C Bord A Péleraux A | 2006 | Mol Cancer Ther2006，5，9： | 1 |
| 14 | Helicobacter pylorivirulence factors and the host immune response:implication for therapeutic vaccination显示文摘 | Prinz C Hafsi N Voland P | 2003 | Trends Microbiol2003，11，3： | 1 |
| 15 | Platelet-osteosaroma cellinteraction is mediated through a specific fibrinogen-binding sequence lo- cated within the N- terminal domain of thrombospondin 显示文摘 | VOLAND C SERRE CM DELMS P | 2000 | J Bone Miner Res2000，15，4： | 1 |
| 16 | Platelet-osteosarcoma cell interaction is mediated through a specific fibrinogen-binding sequence located within the N-terminal domain of thrombospondin l显示文摘 | Voland C Serre CM Delmas P | 2000 | J Bone Miner Res2000，15，2： | 1 |
| 17 | Functional loss of ABCA1 in mice causes severe placental malformation, aberrant lipid distribution, and kidneyglomerulonephritis as well as high-density lipoprotein cholesterol deficiency 显示文摘 | Christiansen-Weber TA Voland JR Wu Y | 2000 | Am J Pathol2000，157，3： | 1 |
| 18 | Enterochromaffin cells of the human gut: sensors for spices and odorants 显示文摘 | Braun T Voland P Kunz L | 2007 | Gastroenterology2007，132，5： | 1 |
| 19 | HeLicobacter pyLori viruLence factors and the host immune response: implications for therapeutic vaccination显示文摘 | Prinz C Nadia H VoLand P | 2003 | Trends MicrobioL2003，11，： | 1 |
| 20 | X-43A Hypersonic Vehicle Technology Development显示文摘 | Voland Randall T Huebner L D | 2006 | Acta Astronautica2006，59，15： | 1 |
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