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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | The epidemiology of post-traumatic Stress disorder after disasters 显示文摘 | Galea S Nandi A Vlahov D | 2005 | Epidemiol Rev2005，27，： | 1 |
| 3 | Oxidative stress parameters as possible urine markers in patients with diabetic nephropathy 显示文摘 | Cvetkovic T Mitic B Lazarevic G Vlahovic P Antic S Stefanovic V | 2009 | J Diabetes Complications2009，23，： | 1 |
| 4 | Urban health:evidence,challenge,and directions显示文摘 | Galea S Vlahov D | | 0，，： | 1 |
| 5 | The epidemiology of post-traumatic stress disorder after disasters显示文摘 | Galea S Nandi A Vlahov D | | 0，，01： | 1 |
| 6 | Urbanization,urbancity,and health显示文摘 | Vlahov D Galea S | 2002 | Journal of Urban Health2002，79，4： | 1 |
| 7 | Dilated heart muscle disease associated with HIV infection显示文摘 | Herskowitz A Willoughby S B Vlahov D | 1995 | Eur Heart J1995，，： | 1 |
| 8 | War and anxiety disorder显示文摘 | Vlahov D Galea S | 2004 | Epidemiology2004，15，2： | 1 |
| 9 | The epidemiology of Post- traumatic stress disorder after disasters 显示文摘 | Galea S Nandi A Vlahov D | 2005 | Epidemiol Rev2005，27，11： | 1 |
| 10 | The epidemiology of post - traumatle stress disorder after disasters显示文摘 | Galea S Nandi A Vlahov D | 2005 | Epidemiol Rev2005，27，： | 1 |
| 11 | Effects of aerobic exercise on micro- albuminuria and enzymuria in type 2 diabetic patients显示文摘 | Lazarevic G Antic S Vlahovic P | 2007 | Ren Fail2007，29，2： | 1 |
| 12 | Effects of aerobic exercise on microalbuminuria and enzymuria in type 2 diabetic patients 显示文摘 | Antic G Viahovic S Vlahovic P | 2008 | Renal Failure2008，29，： | 1 |
| 13 | The epidemidogy of post-traumatic stress disorder after disasters显示文摘 | Galea S Nandi A Vlahov D | 2005 | Epidemiol Rev2005，27，1： | 1 |
| 14 | The epidemiology of post-traumatic stress disorder after disasters 显示文摘 | Galea S Nandi A Vlahov D | 2005 | Epidemiol Rev2005，27，1： | 1 |
| 15 | Unilateral spinal anaes-thesia in a patient with osteogenesis imperfecta with alower legfracture :a case report显示文摘 | Baranovic S LubinaI Z Vlahovic T | 2013 | In Jury2013，44，3： | 1 |
| 16 | Urbanization, Urbanicity, and Health显示文摘 | Vlahov D Galea S | 2002 | Journal of Urban Health:Bulletin of the New York Academy of Medicine Volume 79 Supplement 12002，2002，： | 1 |
| 17 | Preparation of Filter Aids Based on Diatomites显示文摘 | Martinovic S Vlahovic M Boljanac T | 2006 | International Journal of Mineral Processing2006，80，24： | 1 |
| 18 | His panic ethnicity and posttraumatic stress dis order after a disaster: evidence from a general population survey after September 11,2001 显示文摘 | Galea S Vlahov D TracyM | 2004 | 1 Ann Epidemio12004，14，8： | 1 |
| 19 | Urbanization, Urbancity, and Health 显示文摘 | Vlahov D Galea S | 2002 | Journal of Urban Health2002，79，4： | 1 |
| 20 | The epidemiology of post-traumatic stress disorder after disasters显示文摘 | Galea S Nandi A Vlahov D | 2005 | Epidemiol Rev2005，27，： | 1 |
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