3篇
您的检索式：作者名="Vishnu Kumar Gupta"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Intellectu- al capital and performance of pharmaceutical firms in India显示文摘 | Sriranga Vishnu Vijay Kumar Gupta | 2014 | The Journal of Intellectual Capital2014，，1： | 1 |
| 2 | Purification and characterization of CHpro1, a thermotolerant, alkali-stable and oxidation-resisting protease of Chumathang hotspring显示文摘Metagenomic approaches are recently used for searching novel open reading frames(ORFs) coding enzymes employed in pharmaceutical, food industries, etc.In this study, a metagenomic library was constructed from Chumathang hotspring sediment DNA. The library consisted of approximately 9,000 clones and was screened for protease activity. A clone exhibiting protease activity was identified and named CHpro1. Sequencing of CHpro1 revealed that the ORF encoded a functional protein of 363 amino acids belonging to peptidase S8–S53 superfamily.CHpro1 shared 41 % sequence similarity with a reported protease(subtilase family) and 35 % structural similarity with the crystal structure of Pro-Tk sps. of Thermococcus kodarkaenasis. In silico modeling the 3D structure of CHpro1 showed that it has two beta sheets, 10 alpha helices and 11 strands. Catalytic triad prediction implied CHpro1 to be a serine protease. The optimum temperature and p H of the purified protease were found to be 80 °C and 11.0,respectively. The enzyme was active at 5 % concentration of hydrogen peroxide and retained 60 % of activity at 10 %concentration. The thermotolerant, alkalophilic and oxidantstable properties of the protease make it a potential candidate for biotechnological applications. | Reena Singh Chirag Chopra Vishnu Kumar Gupta Bashir Akhlaq Vijeshwar Verma Shafaq Rasool | 2015 | Science Bulletin2015，60，14： | 0 |
| 3 | Transaminitis is an indicator of mortality in patients with COVID-19:A retrospective cohort study显示文摘BACKGROUND Since its discovery in Wuhan,China in December of 2019,the novel coronavirus has progressed to become one of the worst pandemics seen in the last 100 years.Recently,there has been an increased interest in the hepatic manifestations of coronavirus disease 19(COVID-19).AIM To describe the demographic and clinical characteristics of COVID-19 positive patients and study the association between transaminitis and all-cause mortality.METHODS This is a descriptive retrospective cohort study of 130 consecutive patients with a positive COVID PCR test admitted between March 16,2020 to May 14,2020 at a tertiary care University-based medical center.The Wilcoxon-rank sum test and paired t-test were used for comparing non-parametric and parametric continuous variables respectively and a multivariable logistic regression models to study the association between transaminitis and mortality using SAS version 9.4(SAS Institute,Cary,NC,United States).RESULTS Out of the 130 patients,73(56%)patients were found to have transaminitis and 57(44%)did not.When compared to patients without transaminitis,the transaminitis group was found to have a higher median body mass index(30.2 kg/m2 vs 27.3 kg/m2,P=0.04).In the multivariate analysis those with transaminitis were found to have 3.4 times higher odds of dying as compared to those without transaminitis adjusting for gender,the Age-adjusted Charlson Comorbidity Index and admission to the intensive care unit(P=0.03).CONCLUSION Our study showed that transaminitis on admission was associated with severe clinical outcomes such as admission to the intensive care unit,need for mechanical ventilation,and mortality. | Vishnu Charan Suresh Kumar Prateek Suresh Harne Samiran Mukherjee Kashvi Gupta Umair Masood Anuj Vikrant Sharma Jivan Lamichhane Amit Singh Dhamoon Bishnu Sapkota | 2020 | World Journal of Hepatology2020，12，9： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员