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1篇 您的检索式：作者名="Viacheslav N.Azev"

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		题名	作者	年代	出处	被引量
	1	Do reactive oxygen species damage or protect the heart in ischemia and reperfusion?Analysis on experimental and clinical data显示文摘The role of reactive oxygen species(ROS)in ischemic and reperfusion(I/R)injury of the heart has been discussed for more than 40 years.It has been demonstrated that reperfusion triggers a multiple increase in free radical generation in the isolated heart.Antioxidants were found to have the ability to mitigate I/R injury of the heart.However,it is unclear whether their cardioprotective effect truly depends on the decrease of ROS levels in myocardial tissues.Since high doses and high concentrations of antioxidants were experimentally used,it is highly likely that the cardioprotective effect of antioxidants depends on their interaction not only with free radicals but also with other molecules.It has been demonstrated that the antioxidant N-2-mercaptopropionyl glycine or NDPH oxidase knockout abolished the cardioprotective effect of ischemic preconditioning.Consequently,there is evidence that ROS protect the heart against the I/R injury.	Leonid N.Maslov Natalia V.Naryzhnaya Maria Sirotina Alexandr V.Mukhomedzyanov Boris K.Kurbatov Alla A.Boshchenko Huijie Ma Yi Zhang Feng Fu Jianming Pei Viacheslav N.Azev Vladimir A.Pereverzev	2023	The Journal of Biomedical Research2023，37，4：	1

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