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| 1 | Giant hepatic extra-gastrointestinal stromal tumor treated with cytoreductive surgery and adjuvant systemic therapy:A case report and review of literature显示文摘BACKGROUND Primary extra-gastrointestinal stromal tumors(E-GIST)of the liver are rare.The clinical presentation may range from asymptomatic to bleeding or manifestations of mass effect.Oncologic surgery followed by adjuvant therapy with imatinib is the standard of care.However,under specific circumstances,a cytoreductive approach may represent a therapeutic option.We describe herein the case of an 84-year-old woman who presented with a tender,protruding epigastric mass.Abdominal computed tomography scan revealed a large,heterogeneous mass located across segments III,IV,V,and VIII of the liver.The initial approach was transarterial embolization of the tumor,which elicited no appreciable response.Considering the large size and central location of the tumor and the advanced age of the patient,non-anatomic complete resection was indicated.Due to substantial intraoperative bleeding and hemodynamic instability,only a near-complete resection could be achieved.Histopathology and immunohistochemical staining confirmed the diagnosis of primary E-GIST of the liver.Considering the risk/benefit ratio for therapeutic options,debulking surgery may represent a strategy to control pain and prolong survival.CASE SUMMARY Here,we present a case report of a patient diagnosed with E-GIST primary of the liver,which was indicated a cytoreductive surgery and adjuvant therapy with imatinib.CONCLUSION E-GIST primary of the liver is a rare conditional,the treatment is with systemic therapy and total resection surgery.However,a cytoreductive surgery will be necessary when a complete resection is no possible. | Michel Ribeiro Fernandes Caroline Lorenzoni Almeida Ghezzi Tomaz J M Grezzana-Filho Flávia Heinz Feier Ian Leipnitz Aljamir Duarte Chedid Carlos Thadeu Schmidt Cerski Marcio Fernandes Chedid Cléber RositoPinto Kruel | 2021 | World Journal of Gastrointestinal Surgery2021，13，3： | 3 |
| 2 | Effect of various surface modifications of wood flour on the properties of PP/wood composites显示文摘 | Lívia Dányádi János Móczó Béla Pukánszky | 2009 | Composites Part A2009，，2： | 2 |
| 3 | Clinical trials referral resource current clinical trials administering the antiangiogenesis agent SU 5416显示文摘 | VIA L E GORE-LANGTON R E PLUDA J M | 2000 | Oncology (Huntingt)2000，4，： | 1 |
| 4 | Effect of various surface modifications of wood flour on the properties of PP/wood Composites显示文摘 | Lívia Dányádi János Móczó Béla Pukánszky | 2010 | Composites Part A:Applied Polymer Science2010，41，2： | 1 |
| 5 | HMG-CoA reduetase inhibitors reduce MMP-9 secretion by macrophages显示文摘 | Bellota S Via D Canavesi M | 1998 | Arteroseler Thlomb Vasc Biol1998，18，11： | 1 |
| 6 | Synthesis and antiproliferative activity of some new DNA-targeted alkylating pyrroloquinolines 显示文摘 | Ferlin M G Dalla Via L Gia 0 M | 2004 | Bioorganic & Medic- inal Chemistry2004，12，4： | 1 |
| 7 | HM G2COA reductase inhibitons reduce MM P29 secretion by macrophages显示文摘 | Bellosta S Via D Canavesi M | | 0，，： | 1 |
| 8 | A comparative study of four vulnerability mapping methods in a detritic aquifer under mediterraneanclimatic conditions显示文摘 | Draoui M Vias J Andreo B | 2008 | Environ Geol2008，54，3： | 1 |
| 9 | Optode Membrane for generation of its bromoethane derivative 显示文摘 | Choi M M F Wu Xiaojun Li determination of nicotine via Yourong | 1999 | Analytical Chemistry1999，71，7： | 1 |
| 10 | Vulnerability of human environment to risk: Case of groundwater contamination risk显示文摘 | PERLES ROSELLO M J VIAS MARTINEZ J M ANDREO NAVARRO B | 2009 | Environmental Intematianal2009，38，： | 1 |
| 11 | Electrical and Thermal Conductivity and Tensile and Flexural Properties of Carbon Nanotube/Potycarbonate Resins显示文摘 | King J A Via M D Caspary J A | 2010 | Journal of Ap- plied Polymer Science2010，118，5： | 1 |
| 12 | In vivo proton magnetic resonance spectroscopy of diseased prostate: spectroscopic features of malignant versus benign pathology显示文摘 | J.M García-Segura M Sánchez-Chapado C Ibarburen J Via?o J.C Angulo J González J.M Rodríguez-Vallejo | 1999 | Magnetic Resonance Imaging1999，，5： | 1 |
| 13 | HMG - CoA reductase inhibitors reduce MMP - 9 Secretion by macrophages显示文摘 | Bellosta S Via D Canavesi M | 1998 | Arterioscler Thromb Vasc Biol1998，18，： | 1 |
| 14 | Inheritable variable sizes of DNA stretches in tbe human MHC: conserved extended haplotypes and their fragments or blocks 显示文摘 | Yunis EJ Larsen CE Fernandez- Via M | 2003 | Tissue Antigens2003，62，1： | 1 |
| 15 | Salivary Gland Tumor: A Review of 599 Cases in a Brazilian Population显示文摘 | Flávia Aparecida Oliveira Eliza Carla Barroso Duarte Cláudia Teixeira Taveira Aline Abreu Máximo érica Carvalho Aquino Rita de Cássia Alencar Eneida Franco Vencio | 2009 | Head and Neck Pathology2009，，4： | 1 |
| 16 | Local cytokine profiles of patients with cervical intraepithelial and invasive neoplasia显示文摘 | Bethanea Crema Peghini Douglas Reis Abdalla Ana Cristina Macedo Barcelos Lívia das Gra?as Vieito Lombardi Teodoro Eddie Fernando Candido Murta Márcia Antoniazi Michelin | 2012 | Human Immunology2012，，9： | 1 |
| 17 | Int J Radiat Oncol Biol Phys显示文摘 | Mitsudo K Koizumi T Iida M et al Thermochemoradiation therapy using superselective intra - arterial infusion via superficial temporal and occipital arteries for oral cancer with N3 cervical lymph node metastases | | 0，，05： | 1 |
| 18 | HMG-CoA recuctase inhibitors reduce MMP-9 secretionby macrophages显示文摘 | Bellosta S Via D Canavesi M | 1998 | Arterioscler Thromb Vasc Biol1998，18，11： | 1 |
| 19 | Starch,sugarcane bagasse fibre,and polyvinyl alcohol effects on extruded foam properties: A mixture design approach显示文摘 | Suzana M Flávia D Maria V | 2010 | Industrial Crop Product2010，32，3： | 1 |
| 20 | Electrical and thermal conductivity and tensile and flexural properties of carbon nanotube/polycarbonate resins 显示文摘 | KING J A VIA M D CASPARY J A | 2010 | Journal of Applied Polymer Science2010，118，5： | 1 |
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