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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Hepatocellular carcinoma and multidrug resistance: Past, present and new challenges for therapy improvement显示文摘Hepatocellular carcinoma(HCC) is the most frequent form of liver cancer and the third most common cause of cancer-related death in the world. The main risk factor worldwide for this type of malignancy is chronic hepatitis caused by hepatitis B virus and hepatitis C virus infections. Advances in early detection and treatmenthave improved life expectancy of patients with HCC. However, this disorder remains as a disease with poor prognosis. In fact, epidemiological studies have revealed that there is an 8-mo median survival rate in patients, approximately 20% of whom survive one year while only 5% remain alive after three years. Additionally, HCC is particularly difficult to treat because of its high recurrence rate, and its resistance to conventional chemotherapy is due, among other mechanisms, to several members of the ATP-Binding Cassette protein family involved in drug transport being overexpressed. Fortunately, there is evidence that these patients may benefit from alternative molecular-targeted therapies. This manuscript intends to provide further insight into the etiology and molecular mechanisms related to HCC development and the latest therapeutic approaches to treat this malignancy. The development of effective delivery systems of antitumor drugs able to target the liver parenchyma is also assessed. Finally, the prospects in the development of more efficient drug therapies to overcome multidrug resistance are also examined. | María L Cuestas José R Oubia Verónica L Mathet | 2015 | World Journal of Pharmacology2015，4，1： | 2 |
| 3 | Psychosocial intervention improves depression,quality of life,and fluid adherence in hemodialysis显示文摘 | Cukor D Ver Halen N Asher D R | 2014 | J Am Soc Nephrol2014，25，1： | 1 |
| 4 | Direct anterior screw fixation for recent and remote odontoid fractures 显示文摘 | Apfelbaum RI Lonser RR Vers R | 2000 | J Neurosurg2000，93，： | 1 |
| 5 | Stress distributions in plasma-sprayed thermal barrier coatings as a function of interface roughness and oxide scale thickness显示文摘 | AHRENS M VAΒEN R ST?VER D | 2002 | Surface & Coatings Technology2002，161，1： | 1 |
| 6 | Effects of castration and weaning conducted con- currently or consecutively on behavioUr, blood traits and performance in beef calves显示文摘 | Lambertz C Farke - R~ver A Moors E | 2015 | Animal2015，9，1： | 1 |
| 7 | Stimulation of tetanus toxoid - specific immune responses by a tradition-al Chinese herbal medicine显示文摘 | UNDERWOOD J R CHI VERS M DANG T T | 2009 | Vaccine2009，27，47： | 1 |
| 8 | Spatial hetero-geneity in eight central Texas grasslands显示文摘 | Miller R E Ver Hoe J M Fowler N L | 1995 | Journal of Ecology1995，83，： | 1 |
| 9 | Fundamentals of scatter search and path relinking 显示文摘 | GIX)VER F LAGUNA M MARTI R | 2000 | Control and Cybernetic2000，29，3： | 1 |
| 10 | Spatial heterogeneity in eight central Texas grasslands 显示文摘 | Ver Hoef J M Fowler N L | 1995 | Journal of Ecology1995，83，： | 1 |
| 11 | Serologic survey for canine coronavirus in wolves from Alaska显示文摘 | Zarnke R L Evermann J Ver Hoef J M | 2001 | J Wildlife Dis2001，37，： | 1 |
| 12 | The effect of dietary ractopamine concentration and duration of feeding on growth performance,carcass characteristics,and meat quality of finishing pigs显示文摘 | Armstrong T A Vers D J Wagner J R | 2004 | J Anim Sci2004，82，11： | 1 |
| 13 | Spatial heterogeneity in eight central Texas grasslands显示文摘 | Miller R E Ver H J M Fowler N L | 1995 | Journal of Ecology1995，83，： | 1 |
| 14 | Processing and Properties of Nanophase Ceramics显示文摘 | Vaben R Stoèver D | 1999 | Journal of Materials Processing Technology1999，9293，： | 1 |
| 15 | Spatial heterogeneity within the plough layer: high variability of N2O emission rates显示文摘 | R(O)VER M HEINEMEYER O MUNCH J C | 1999 | Soil Biol Biochem1999，31，： | 1 |
| 16 | Gastrointestinal hormones in short bowel syndrome, Peptide YY may be the “colonic brake” togastric emptying显示文摘 | Nightingale J M Kamm M A ver der sijp J R | 1996 | Gut1996，39，2： | 1 |
| 17 | Law, Evidence and ElectronicRecords: A Strategic Perspective from the Global Periphery显示文摘 | Ver ne Har r is | 2001 | Comma2001，，12： | 1 |
| 18 | A randomised compar ision of int ravenous remifentanil patient-cont rolled analgesia with epidural ropivacaine/sufentanil during labour显示文摘 | Douma MR Middeldor p JM Ver wey R A | 2011 | Int J Obstet Anesth2011，20，2： | 1 |
| 19 | Spatial heterogeneity in eight central Texas grasslands显示文摘 | Miller R E Ver Hoef J M Fowler N L | 1995 | Journal of Ecology1995，83，： | 1 |
| 20 | New Thermal Barrier Coatings Based on Pyrochlore/YSZ Double-Layer Systems显示文摘 | Vaβen R Traeger F St(o)ver D | | 0，，04： | 1 |
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