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| 1 | Measurements of human breast cancer using magnetic resonance spectroscopy:a review of clinical measurements and a report of localized ^31p measurements of response to treatment显示文摘 | Leach M O Verrill M Glahoim J Smith T A Coliins D J Payne G S | 1998 | NMR Biomed1998，11，： | 1 |
| 2 | Capecitabine and vinorelbine in metastatic breast cancer 显示文摘 | Chan A Verrill M | 2009 | Eur J Cancer2009，45，13： | 1 |
| 3 | Proteomie analysis reveals a novel role for the actin cytoskeleton in vineristine resistant childhood leukemia-an in vivo study显示文摘 | Verrills N M Lock R B Kavallaris M | 2006 | Proteomics2006，6，5： | 1 |
| 4 | Microtubule alterationsand mutations induced by desoxyepothilone B:implications fordrug-target interactions显示文摘 | VERRILS N M FLEMMING C L LIU M | 2003 | Chemistry & Biology2003，10，7： | 1 |
| 5 | Proteome analysis of vinca alkaloid response and resistance in acute lymphoblastic leukemia reveals novel eytoskeletal alterations显示文摘 | Verrills N M Walsh B J Cobon G S | 2003 | J Biol Chem2003，278，45： | 1 |
| 6 | Incidence of P-glycoprotein over expression and mustidrug resistance reversalin adult soft tissue sarcoma显示文摘 | Coley H M Verril M W G Regson S E | 2000 | Eur Cancer2000，36，5： | 1 |
| 7 | Drug resistance mechanisms in cancer cells: a proteomics perspective显示文摘 | Kavallaris M | 2003 | Curr Opin Mol Ther2003，5，3： | 1 |
| 8 | Capecitabine and vinorelbine in metastatic breast cancer显示文摘 | ChanA Verrill M | 2009 | Eur J Cancer2009，45，13： | 1 |
| 9 | Controllingthe cell cycle: the role of calcium/calmodulin-stimulated protein kinases I and II 显示文摘 | SKELDINC K A ROSTAS J A VERRILLS N M | 2011 | Cell Cycle2011，10，4： | 1 |
| 10 | Proteome analysis of vinca alkaloid response and resistance in acute lymphoblastic leukemia reveals novel cytoskeletal alterations显示文摘 | Verrills N M Walsh B J Cobon G S | 2003 | J Biol Chem2003，278，45： | 1 |
| 11 | Subproteomics based upon protein cellular location and relative solubilities in conjunction with composite two-dimensional electrophoresis gels 显示文摘 | Cordwell S J Nanwens A S Verrills N M | 2000 | Electrophoresis2000，21，： | 1 |
| 12 | Measurements of human breast cancer using magnetic resonance spectroscopy:a review of clinical measurements and a report of localized 31P measurements of response to treatment显示文摘 | Leach MO Verrill M Glaholm J | 1998 | NMR Biomed1998，11，： | 1 |
| 13 | Ewing's sarcoma and primitive neuroectodermal tumor in adults: are they different from ewing's sarcoma and primitive neuroectodermal tumor in children 显示文摘 | Verrill M W Judson I R Harmer C L | 1997 | J Clin Oncol1997，15，7： | 1 |
| 14 | Ewing' s sarcoma and primitive neuroectodermal tumor in adults: are they different from Ewing's sarcoma and primitive neuroectodermal tumor in children? 显示文摘 | Verrill M W Judson I R Harmer C L | 1997 | JClinOncol1997，15，7： | 1 |
| 15 | Anticaneer therapy with novel tubuiin-interacting drugs 显示文摘 | Kavallaris M Verrills NM Hill BT | 2001 | Drug Resist Updat2001，4，6： | 1 |
| 16 | Ewing's sarcoma and primitive neuroectodermal tumor in adults:are they different from Ewing's sarcoma and primitive neuroectodermal tumor in children显示文摘 | VERRILL M W JUDSON I R HARMER C L | 1997 | J Clin Oncol1997，15，6： | 1 |
| 17 | Validation of methods to assess potential biomarkers in pediatric patients with esophageal eosinophilia显示文摘AIM:To validate methods for determining mast cell density,extracellular major basic protein content,and presence of fibrosis in esophageal eosinophilia.METHODS:Twenty specimens with > 20 eosinophils/high-power field(hpf) classified as high eosinophil density(HE) and 20 specimens with < 5 eosinophils/hpf classified as low esophageal density(LE) were identified.All 40 specimens underwent immunohistochemical staining and trichrome staining.Mast cell density,extracellular major basic protein(MBP) density,and presence of subepithelial fibrosis were assessed in a standardized manner.All specimens were evaluated by two separate observers and by a single observer on two separate occasions to evaluate reproducibility of the methods.RESULTS:A strong inter-observer correlation was noted for both peak and mean mast cell counts(r = 0.725,P < 0.0001 and r = 0.823,P < 0.0001).A strong intraobserver correlation also was noted for both peak and mean mast cell counts(r = 0.752,P < 0.0001 and r =0.878,P < 0.0001).A very strong inter-observer correlation was noted for both peak(τ = 0.867,P < 0.0001)and mean extracellular MBP densities(r = 0.925,P <0.0001).A very strong intra-observer correlation was noted for both peak(τ = 0.875;P < 0.0001) and mean extracellular MBP densities(r = 0.956,P < 0.0001).Excellent inter-rater reliability was found for fibrosis(κ= 0.887).Mast cell and MBP densities,as well as presence of fibrosis,were significantly increased in HE vs LE.The HE group had significantly higher intraepithelial mast cell peak(29.35 ± 21.61 vs 12.45 ± 8.26,P =0.002) and mean(19.84 ± 15.81 vs 6.35 ± 4.5,P =0.001) densities than the LE group.The HE group had significantly higher peak extracellular MBP(2.35 ± 0.67vs 0.45 ± 0.61,P < 0.001) and mean extracellular MBP(1.95 ± 0.76 vs 0.20 ± 0.29,P < 0.0001) densities than the LE group.Seventy-three percent of patients with HE(11/15) had fibrosis,whereas only 10% of patients with LE(1/10) had fibrosis(P < 0.01).MBP performed the best in predicting classification of HE vs LE,with mean MBP demonstrating 100% sensitivity and95% specificity at the optimal cut point.CONCLUSION:This study provides methodology and proof-of-concept for future evaluation of these biomarkers for differentiating esophageal eosinophilic diseases such as reflux esophagitis and eosinophilic esophagitis. | Jennifer M Colombo Nancy A Neilan Jennifer Verrill Schurman Craig A Friesen | 2013 | World Journal of Gastrointestinal Pharmacology and Therapeutics2013，4，4： | 0 |
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