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| 1 | Clozapine is strongly associated with the risk of pneumonia and inflammation显示文摘Clinicians need to remember that(1)systemic inflammations can increase clozapine level;(2)clozapine,by itself,can cause inflammation,particularly during titration that is too rapid for that patient;(3)clozapine may increase the risk of infection;and(4)more specifically,clozapine may be particularly strongly associated with the risk of pneumonia.Pneumonia appears to be associated with high mortality in clozapine patients around the world.Clinicians who are alert to the risk of pneumonia in clozapine patients may significantly decrease mortality in clozapine patients.There is no data on COVID-19 infections in clozapine patients,but based on what we know about clozapine pharmacology,we can hypothesise that clozapine,possibly by impairing immunological mechanisms,may increase the risk of pneumonia in infected patients.More importantly,once fever and/or pneumonia develops,the clozapine dose should be cut in half to decrease the risk of clozapine intoxication.If there is any doubt that in spite of halving the dose there are still signs of clozapine intoxication,completely stopping clozapine may be indicated.Once the signs of inflammation and fever have disappeared,the clozapine dose can be increased to the prior dosage level. | Jose de Leon Can-Jun Ruan Helene Verdoux Chuanyue Wang | 2020 | General Psychiatry2020，33，2： | 1 |
| 2 | Dysphoric mania and mixed states显示文摘 | Verdoux H Mainard CH | 1995 | Encephale1995，6，： | 1 |
| 3 | Prospective,multicentre,randomized,double-blind study of the efficacy of escitalopram versus citalopram in outpatient treatment of major depressive disorder显示文摘 | Moore N Verdoux H Fantino B | | 0，，： | 1 |
| 4 | eitalopram in major depressive disorder显示文摘 | Fantino Moore Verdoux Cost-effectiveness of escitalopram vs | 2007 | Int Clin Psychopharmacol2007，22，2： | 1 |
| 5 | Obstetric complications and age at onset in schizophrenia: an international collaborative meta-analysis of individual patient data显示文摘 | Verdoux H Geddes JR Takei N | 2001 | Am J Psychiatry2001，154，9： | 1 |
| 6 | Obstetric complications and age at onset in schizophrenia :an international collaborative meta2 analysis of individual patient data显示文摘 | VERDOUX H GEDDES J R TAKEI N | 2001 | Am J Psychiatry2001，154，12： | 1 |
| 7 | Prospective,multicentre,random- ized,double-blind study of the efficacy of escitalopram,citalopram in outpatient of major depressive disorder显示文摘 | Moore N Verdoux H Fantino B | 2005 | Int Clin Psychopharmacology2005，20，3： | 1 |
| 8 | Prospective, multicentre, randomized, double - bund study of the efficacy ofescitalopram versus eitalopram inoutpatient treatment of major depressive disorder 显示文摘 | Moore N Verdoux H Fantino B | 2005 | lnt Clin Psychopharmcol2005，20，3： | 1 |
| 9 | ProsPective,multicentre,randomized,double-blind studr of the efficacy of escitaloPram versus citaloPranl in outPatien ttreatment of major depressive disorder显示文摘 | Moore N Verdoux H Fantino B | 2005 | Int Clin Psycho Pharmool2005，20，： | 1 |
| 10 | Depression and severe heart failure : benefits of cardiac resynchronization therapy 显示文摘 | Ploux S Verdoux H Whinnett Z | 2012 | J Cardiovase Eleetrophysiol2012，23，6： | 1 |
| 11 | Obstetric complications and age at on set in schizophrenia: an international collaborative meta-analysis of individual patient data 显示文摘 | Verdoux H Geddes JR Takei N | 1997 | Am J Psychiatry1997，154，9： | 1 |
| 12 | Effect of transcutaneous electroacupuncture at Neiguan(PC 6) on refractory vomiting in patients in intensive care unit显示文摘OBJECTIVE: To observe the effect of transcutaneous electroacupuncture(TEA) at Neiguan(PC 6) on refractory vomiting in critically ill patients in intensive care(ICU) setting.METHODS: Ten patients admitted in ICU and presenting vomiting refractory to one or more antiemetic drugs were prospectively included in the study. TEA was applied at acupoint of Neiguan(PC6) during 30 min with a neuromuscular transmission monitor(single-twitch stimulation with 1 Hz at a constant current of 10 m A). Nausea and Vomiting were evaluated at the following intervals: immediately after 30 min of TEA at Neiguan(PC 6),30 min-6h and 6-24 h. The presence of nausea and/or vomiting throughout the observational period was defined as the primary end point.RESULTS: The presence of nausea or vomiting throughout the observational period was 10% at the end of TEA, 40% between 30 min and 6 h, and50% between 30 min and 24 h(P < 0.001, P = 0.01 and P = 0.03 vs pre-TEA, respectively). There were no complications or side effects related to TEA.CONCLUSION: TEA at Neiguan(PC 6) seems effective in reducing refractory vomiting in the patients in ICU setting, even if larger trials are needed to define optimal modalities. | Benoit Bataille Carine Chan-Shun Bastian Nucci Bernard Verdoux Michel Mora Pierre Cocquet Stein Silva | 2017 | Journal of Traditional Chinese Medicine2017，37，4： | 1 |
| 13 | How to improve recognition and diagnosis of depressive syndromes using international diagnostic criteria显示文摘 | MAURICE-TISON S VERDOUX H GAY B | 1998 | Br J Gen Pract1998，48，430： | 1 |
| 14 | Prospective, multieentre, randomized, doubleblind study of the effieaey of eseitalopram versus eitalopram in outpatient treatment of major depressive disorder显示文摘 | Moore N Verdoux H Fantino B | 2005 | Int Clin Psychopharmeol2005，20，： | 1 |
| 15 | Prospective, muhieentre, randomized, double - blind study of the efficacy of eseitalopram versus eitalopram in outpatient treatment of major depressive disorder显示文摘 | Moore N Verdoux H Fantino B | 2005 | Int Clin Psycho- pharm Aeo12005，20，1： | 1 |
| 16 | Obstetrical complications and the development of postpartum depressive symptoms: a prospective survey of the MATQUID cohort显示文摘 | Verdoux H Sutter AL Glatigny-Dallay E | 2002 | Acta Psychiatr Scand2002，106，3： | 1 |
| 17 | Obstetric complications and age at onset in schizophrenia; an international collaborative metaanalysis of individual patient data显示文摘 | Verdoux H Geddes JR Takei N | 2001 | AmJ Psychiatry2001，154，9： | 1 |
| 18 | Effects of cannabis and psychosis vulnerability in daily life: an experience sampling test study显示文摘 | Verdoux H Gindre C Sorbara F | 2003 | Psychol Med2003，33，： | 1 |
| 19 | Prospective, multicentre, randomized, double-bund study of the efficacy of escitalopram versus citalopram in outpatient treatment of major depressive disorder 显示文摘 | Moore N Verdoux H Fantino B | 2005 | Int Clin Psychopharmcol2005，20，3： | 1 |
| 20 | Dysphorie mania and mixed states显示文摘 | Bourgeois M Verdoux H Mainard CH | 1995 | Eneephale1995，6，： | 1 |
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