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| 1 | Influence of aging on peripheral nerve function and regeneration显示文摘 | Verdú E Ceballos D Vilches J J | 2000 | J Peripher Nerv Syst2000，5，4： | 1 |
| 2 | Valproate reducesCHOP levels and preserves oligodendrocytes and axons afterspinal cord injury显示文摘 | Penas C VerdúE Asensio PE | 2011 | Neuroscience2011，178，： | 1 |
| 3 | Morphometric and ultrastructural changes with aging in mouse peripheral nerve显示文摘 | Ceballos D Cuadras J Verdú E | 1999 | J Anat1999，195，： | 1 |
| 4 | Nerve guides seeded with autologous schwann cells improve nerve regeneration显示文摘 | Rodríguez FJ Verdú E Cebal os D | | 0，，02： | 1 |
| 5 | Conservation strategy of a nature reserve in Mediterranean ecosystems: the effects of protection from grazing on biodiversity 显示文摘 | Verdú J R Crespo M B Galante E | 2000 | Biodiversity and Conservation2000，9，12： | 1 |
| 6 | Acute and delayed transplantation of olfactory ensheathing cells promote partial recovery after complete transection of the spinal cord显示文摘 | López-Vales R Forés J VerdúE | 2006 | Neurobiol Dis2006，21，1： | 1 |
| 7 | Effects of ensheathing cells transplanted into photochemically damaged spinal cord显示文摘 | Verdú E García-Alías G Forés J | 2001 | Neuroreport2001，12，11： | 1 |
| 8 | Alignment of col agen and laminin-containing gels improve nerve regeneration within silicone tubes显示文摘 | Verdú E Labrador RO Rodríguez FJ | | 0，，05： | 1 |
| 9 | Visceral hyperalgesia and intestinal dysmotility in a mouse model of postinfective gut dysfunction显示文摘 | Bercík P Wang L Verdú E F | 2004 | Gastroenterology2004，127，： | 1 |
| 10 | Visceral hyperalgesia and intestinal dysmotility in a mouse model of postinfective gutdysfunction显示文摘 | Bercìk P Wang L Verdú E F | 2004 | Gastroenterology2004，127，： | 1 |
| 11 | Olfactory bulb ensheathing cells enhance peripheral nerve regeneration显示文摘 | Verdú E Navarro X Gudi(n)o-Cabrera G | 1999 | Neuroreport1999，10，5： | 1 |
| 12 | Spinal cord injury induces endoplasmic reticulum stress w ith different cell-type dependent response显示文摘 | Penas C Guzmn MS VerdúE Forés J Navarro X Casas C | 2007 | J Neurochem2007，102，4： | 1 |
| 13 | Effect of Aspergillus niger prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet显示文摘BACKGROUND The gluten-free diet(GFD)has limitations,and there is intense research in the development of adjuvant therapies.AIM To examine the effects of orally administered Aspergillus niger prolyl endopeptidase protease(AN-PEP)on inadvertent gluten exposure and symptom prevention in adult celiac disease(CeD)patients following their usual GFD.METHODS This was an exploratory,double-blind,randomized,placebo-controlled trial that enrolled CeD patients on a long-term GFD.After a 4-wk run-in period,patients were randomized to 4 wk of two AN-PEP capsules(GliadinX;AVI Research,LLC,United States)at each of three meals per day or placebo.Outcome endpoints were:(1)Average weekly stool gluten immunogenic peptides(GIP)between the run-in and end of treatments and between AN-PEP and placebo;(2)celiac symptom index(CSI);(3)CeD-specific serology;and(4)quality of life.Stool samples were collected for GIP testing by ELISA every Tuesday and Friday during run-ins and treatments.RESULTS Forty patients were randomized for the intention-to-treat analysis,and three were excluded from the per-protocol assessment.Overall,628/640(98.1%)stool samples were collected.GIP was undetectable(<0.08μg/g)in 65.6%of samples,and no differences between treatment arms were detected.Only 0.5%of samples had GIP concentrations sufficiently high(>0.32μg/g)to potentially cause mucosal damage.Median GIP concentration in the AN-PEP arm was 44.7%lower than in the run-in period.One-third of patients exhibiting GIP>0.08μg/g during run-in had lower or undetectable GIP after AN-PEP treatment.Compared with the run-in period,the proportion of symptomatic patients(CSI>38)in the AN-PEP arm was significantly lower(P<0.03).AN-PEP did not result in changes in specific serologies.CONCLUSION This exploratory study conducted in a real-life setting revealed high adherence to the GFD.The AN-PEP treatment did not significantly reduce the overall GIP stool concentration.However,given the observation of a significantly lower prevalence of patients with severe symptoms in the AN-PEP arm,further clinical research is warranted. | Juan Pablo Stefanolo Verónica Segura Martina Grizzuti Abel Heredia Isabel Comino Ana Florencia Costa Roberto Puebla María Paz Temprano Sonia Isabel Niveloni Gabriel de Diego María E Oregui Edgardo Gustavo Smecuol Mauricio C de Marzi Elena F Verdú Carolina Sousa Julio César Bai | 2024 | World Journal of Gastroenterology2024，30，11： | 0 |
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