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| 1 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 2 | Mortality and prehospital thrombolysis for acute myocardial infarction: a meta-analysis显示文摘 | Morrison LJ Verbeek PR McDonald AC | 2000 | JAMA2000，283，： | 1 |
| 3 | Mortality and prehospital thrombolysis for acute myocardial infarction: A meta - analysis 显示文摘 | Morrison L J Verbeek PR McDonald Ac | 2000 | JAMA2000，283，20： | 1 |
| 4 | Comparison of the medical priority dispatch system to an out - of - hospital patient acuity score显示文摘 | Feldman M J Verbeek PR Lyons DG | 2006 | Academic Emergency Medicine2006，13，9： | 1 |
| 5 | Mortality andhospital thrombolysis for acute myodial infarction:a meta-analysis显示文摘 | Morrison LJ Verbeek PR Donald AC | | 0，，： | 1 |
| 6 | The Role of EMS in Regionalized Systems of Care显示文摘 | Drennan IR Verbeek PR | 2015 | CJEM2015，，15： | 1 |
| 7 | Half-a-million strong: The emergency medical services response to a single-day, massgathering event 显示文摘 | Feldman MJ Lukins JL Verbeek PR | 2004 | Prehosp Disast Med2004，19，4： | 1 |
| 8 | Mortality and prehospital thrombolysis for acute myocardial infarction:A meta-analysis显示文摘 | Verbeek PR | 2000 | JAMA2000，183，10： | 1 |
| 9 | Mortality and prehospital thrombolysis for acute myocardial infarction:a meta-analysis 显示文摘 | Morrison LJ Verbeek PR MeDonald AC | 2000 | JAMA2000，283，： | 1 |
| 10 | Serial prehospital 12-lead electrocardiograms increase identification of ST-segment elevation myocardial infarction显示文摘 | Verbeek PR Ryan D Turner L | 2012 | Prehosp Emerg Care2012，16，1： | 1 |
| 11 | Mortality and prehospital thrombolysis for acute myocardial infarction:A meta-analysis显示文摘 | Morrricon LJ Verbeek PR Mcdonald AC | 2000 | JAMA2000，283，20： | 1 |
| 12 | Derivation and evaluation of a termination of resuscitalion clinical prediction rule for advanced life support providers显示文摘 | Morrison LI Verbeek PR Vermeulen MJ | 2007 | Resuscitation2007，74，2： | 1 |
| 13 | Prehospital transcutaneous cardiac pacing for symptomatic bradycardia or bradyasystolic cardiac arrest:a systematic review显示文摘 | Sherbino J Verbeek PR MacDonald RD | 2006 | Resuscitation2006，70，2： | 1 |
| 14 | Mortality and prehospital thrombolysis for acute myocardial infarction: a meta-analysis 显示文摘 | Morrison LJ Verbeek PR McDonald AC | 2000 | JAMA2000，283，20： | 1 |
| 15 | Mortality and prehospital thrombolysis for acute myocardial infarction:a meta-analysis显示文摘 | Morrison LJ Verbeek PR McDonald AC | 2000 | JAMA2000，283，20： | 1 |
| 16 | Mortality and prehospital thrombolysis for acute myocardil infarction: a meta analysis显示文摘 | Morrison U Verbeek PR McDonald AC | 2000 | JAMA2000，283，： | 1 |
| 17 | Serial prehospital 12-lead electrocardiograms increase identification of ST-segment elevation myocardial infarction 显示文摘 | Verbeek PR Ryan D Turner L | 2012 | Prehosp Emerg Care2012，16，1： | 1 |
| 18 | Mortality and prehospital thrombolysis for acute myocardial infarction:A metaanalysis显示文摘 | Morrison LJ Verbeek PR McDonald AC | 2000 | JAMA2000，283，20： | 1 |
| 19 | Morlality and prehospital thrombolysis for acute myocardial infarction: A meta-- analysis显示文摘 | Morrison LJ Verbeek PR Mc Donald Ac | 2000 | JAMA2000，283，20： | 1 |
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