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| 1 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 2 | Vertebral artery embolism after acute cervical spine trauma显示文摘 | VERAS L M PEDRAZA GUTIERREZ S CASTELLANOS J el al | 2000 | Spine2000，25，9： | 1 |
| 3 | Is C-reative protein an independent risk factor for essential hypertension显示文摘 | BAUTISTA L E LOPEZ-JARAMILLO P VERA L M | 2001 | J Hypertens2001，19，5： | 1 |
| 4 | Independent association between inflammatory markers (C-reactive protein, interleukin-6, and TNF-alpha) and essential hypertension 显示文摘 | Bautista L E Vera L M Arenas I A | 2005 | J Hum Hypertens2005，19，2： | 1 |
| 5 | Independent association between inflammatory markers (C- reactive protein, interleukin-6, and TNFα) and essential hypertension显示文摘 | BAUTISTA L E VERA L M ARENAS I A | 2005 | J Hum Hypertens2005，19，1： | 1 |
| 6 | Effects of virtual reality immersion and audiovisual distraction techniques for patients with pruritus显示文摘 | Vera L Florella M Sarale C et a1 | 2009 | Pain Res Manag2009，14，4： | 1 |
| 7 | Characteris-tics of Hemocompatible Ti02 Nano- films Produced by theSol-gel and Anodic Oxidation Techniques 显示文摘 | Schvezov C E Alterach M A Vera M L | 2010 | Jom2010，62，6： | 1 |
| 8 | Insulin-like growth factor-I cDNA cloning, gene expression and potential use as a growth rate indicator in Nile tilapia, Oreochromis niloticus 显示文摘 | Vera Cruz E M Brown C L Adam Luckenbach J | 2006 | Aquaculture2006，251，： | 1 |
| 9 | Fiber (Glucomannan) is beneficial in the treatment of childhood constipation 显示文摘 | Vera L B Erasmo M Staiano A | 2004 | Pediatrics2004，113，3： | 1 |
| 10 | Spectroscopic characterization of doped poly(benzidine) and its nanocomposite with cationic clay显示文摘 | Gustavo M do Nascimento Vera R L Constantino Marcia L A Temperini | 2004 | Journal of Physical Chemistry B2004，108，18： | 1 |
| 11 | Effects of altitude and seed size on geanination and seedling survival of heathland plants in north Spain 显示文摘 | Vera M L | 1997 | Plant E- cology1997，133，1： | 1 |
| 12 | Is C-reactive protein an independent risk factor for essential hypertension?显示文摘 | BAUTISTA L E LOPEZ-JARAMILLO P VERA L M | 2001 | J Hypertens2001，19，5： | 1 |
| 13 | Anti-inflammatory and antinociceptive activities of the ethanolic extract of Bougainvillea xbuttiana显示文摘 | A L Alvarez Perez Gil L Barbosa Navarro M Patipo Vera | 2012 | J Ethnopharmacol2012，144，31： | 1 |
| 14 | Adaptive quadrature filters for muhiple phase-stepping images显示文摘 | Marroquin J L Servin M Rodriguez Vera R | 1998 | Optics Letters1998，23，4： | 1 |
| 15 | Conservative treatment of displaced fractures of the o- lecranon in the elderly 显示文摘 | Veras Del Monte L Sirera Vercher M Busquets Net R | 1999 | Injury1999，30，2： | 1 |
| 16 | C-reactive protein is an independent risk factor for essential hypertension 显示文摘 | Bautista L E Lopez-Jaramillo P Vera L M | 2001 | Hypertens2001，19，5： | 1 |
| 17 | Effects of altitude and seed mass on germination and seedling survival of heathland plants in north Spain显示文摘 | Vera M L | 1997 | Plant Ecology1997，133，： | 1 |
| 18 | New sensitive layers for surface acoustic wave gas sensors based on polymer and carbon nanotube composites显示文摘 | Sayago I Fern ndez M J Fontecha J L Horrillo M C Vera C Obieta I Bustero I | 2012 | Sensors and Actuators B:Chemical2012，175，： | 1 |
| 19 | Two years monitoring of the natural system for wastewater reclamation in Santa Lucía,Gran Canaria Island显示文摘 | Vera L Martel G Márquez M | 2013 | Ecological Engineering2013，50，： | 1 |
| 20 | Effect of Water Vapor on the Activity of Pt-Pd/Al2O3 Catalysts for Methane Cobustion显示文摘 | Pieck C L Vera C R Peirotti E M | 2002 | Applied Catalysis A:General2002，226，： | 1 |
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