|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effects of halobenzoquinone and haloacetic acid water disinfection byproducts on human neural stem cells显示文摘Human neural stem cells(h NSCs) are a useful tool to assess the developmental effects of various environmental contaminants; however, the application of h NSCs to evaluate water disinfection byproducts(DBPs) is scarce. Comprehensive toxicological results are essential to the prioritization of DBPs for further testing and regulation. Therefore, this study examines the effects of DBPs on the proliferation and differentiation of h NSCs. Prior to DBP treatment, characteristic protein markers of h NSCs from passages 3 to 6 were carefully examined and it was determined that h NSCs passaged 3 or 4 times maintained stem cell characteristics and can be used for DBP analysis. Two regulated DBPs, monobromoacetic acid(BAA) and monochloroacetic acid(CAA), and two emerging DBPs, 2,6-dibromo-1,4-benzoquinone(2,6-DBBQ) and 2,6-dichloro-1,4-benzoquinone(2,6-DCBQ), were chosen for h NSC treatment. Both 2,6-DBBQ and 2,6-DCBQ induced cell cycle arrest at S-phase at concentrations up to 1 μmol/L. Comparatively, BAA and CAA at 0.5 μmol/L affected neural differentiation. These results suggest DBP-dependent effects on h NSC proliferation and differentiation. The DBP-induced cell cycle arrest and inhibition of normal h NSC differentiation demonstrate the need to assess the developmental neurotoxicity of DBPs. | Katherine Z.Fu Jinhua Li Sai Vemula Birget Moe Xing-Fang Li | 2017 | Journal of Environmental Sciences2017，29，8： | 7 |
| 2 | Studying developmental neurotoxic effects of bisphenol A(BPA) using embryonic stem cells显示文摘There is little to no toxicity information regarding thousands of chemicals to which people are exposed daily.In fact,of the84,000 chemicals listed in the United States Toxic Substances Control Act Inventory,there is limited information available on their effects on neural development(Betts,2010;US EPA,2015).The number of chemicals tested remains low due to the high cost of conducting multi-generational animal | Jinhua Li Katherine Z.Fu Sai Vemula X.Chris Le Xing-Fang Li | 2015 | Journal of Environmental Sciences2015，27，10： | 6 |
| 3 | Nitric oxide regulation of plant metabolism显示文摘Nitric oxide(NO)has emerged as an important signal molecule in plants,having myriad roles in plant devel-opment.In addition,NO also orchestrates both biotic and abiotic stress responses,during which intensive cellular metabolic reprogramming occurs.Integral to these responses is the location of NO biosynthetic and scavenging pathways in diverse cellular compartments,enabling plants to effectively organize signal transduction pathways.NO regulates plant metabolism and,in turn,metabolic pathways reciprocally regu-late NO accumulation and function.Thus,these diverse cellular processes are inextricably linked.This re-view addresses the numerous redox pathways,located in the various subcellular compartments that pro-duce NO,in addition to the mechanisms underpinning NO scavenging.We focus on how this molecular dance is integrated into the metabolic state of the cell.Within this context,a reciprocal relationship be-tween NO accumulation and metabolite production is often apparent.We also showcase cellular pathways,including those associated with nitrate reduction,that provide evidence for this integration of NO function and metabolism.Finally,we discuss the potential importance of the biochemical reactions governing NO levels in determining plant responses to a changing environment. | Kapuganti Jagadis Gupta Vemula Chandra Kaladhar Teresa B.Fitzpatrick Alisdair R.Fernie Ian Max Møller Gary J.Loake | 2022 | Molecular Plant2022，15，2： | 2 |
| 4 | Silver-nanoparticle-embedded antimicrobial paints based on vegetable oil显示文摘 | KUMAR A VEMULA P K AJAYAN P M | 2008 | Nat Mater2008，7，： | 1 |
| 5 | Sensor self-localization with beacon position uncertainty显示文摘 | Vemula M Bugalb M F Djuric P M | | 0，，06： | 1 |
| 6 | Target tracking by particle filtering in binary sensor networks 显示文摘 | DJURIC P M VEMULA M BUGALLO M F | 2008 | IEEE Transactions on Signal Processing2008，56，6： | 1 |
| 7 | Silver-nanoparticle-embedded antimicrobial paints based on vegetable oil显示文摘 | Kumar A Vemula PK Ajayan PM | 2008 | Nature Materials2008，7，3： | 1 |
| 8 | Molecu- lar analysis of a case of nevus of ota showing progressive evolution to melanoma with intermediate stages resembling cellular blue ne- vus显示文摘 | Gerami P Pouryazdanparast P Vemula S Bastian B C | 2010 | Am J Dermatopathol2010，32，3： | 1 |
| 9 | Target tracking by particle filtering in binary sensor networks显示文摘 | DJURIC P M VEMULA M BUGALLO M F | 2008 | IEEE Transactions on Signal Processing2008，56，6： | 1 |
| 10 | Recent advances in cardanol chemistry in a nutshell: From a nut to nanomaterials显示文摘 | BALACHANDRAN V S JADHA V S R VEMULA P K | 2013 | Chemical Society Reviews2013，42，2： | 1 |
| 11 | Target tracking by particle filtering in binary sensor networks显示文摘 | Djuric P M Vemula M Bugullo M F | 2008 | IEEE Trans on Signal Processing2008，56，6： | 1 |
| 12 | Target tracking by particle filtering in binary sensor networks显示文摘 | Djuric P M Vemula M Bugallo M F | 2008 | IEEE Trans on Signal Processing2008，56，6： | 1 |
| 13 | Target Tracking by Particle Filleting in Binary Sensor Networks显示文摘 | DJURIC P M VEMULA M BUGALLO M F | 2008 | IEEE Transactions on Signal Processing2008，56，6： | 1 |
| 14 | Formulation and pharmacokinetics of colon-specific double-compression coated mini-tablets:chronopharmaceutical delivery of ketorolac tromethamine显示文摘 | Vemula S K | 2015 | Int JPharm2015，491，12： | 1 |
| 15 | Sensor self-localization with beacon position uncertainty显示文摘 | Vemula M Bugallo M F Djuri(c) P M | 2009 | Signal Processing2009，89，6： | 1 |
| 16 | Formulation and pharmacokinetics of colon-specific double- compression coated mini-tablets:Chronopharmaceutical delivery of ke- torolac tromethamine显示文摘 | Vemula SK | 2015 | Int J Pharm2015，491，12： | 1 |
| 17 | ROCKlfunctions as a sup- pressor of inflammatory cell migration by regulating PTEN phospho- rylation and stability显示文摘 | Vemula S Shi J Hanneman P | 2009 | Blood2009，115，9： | 1 |
| 18 | Emerging strategies for epha2 receptor targeting for cancer therapeutics 显示文摘 | Tandon M Vemula SV Mittal SK | 2011 | Expert Opin Ther Targets2011，15，： | 1 |
| 19 | Recent advances in cardanol chemistry in a nutshell:from a nut to nanomaterials显示文摘 | Balachandran V S Jadhav S R Vemula P K | 2013 | Chemical Society Reviews2013，42，2： | 1 |
| 20 | Target tracking by particle filtering in binary sensor networks显示文摘 | Djuric P M Vemula M Bugallo M F | 2008 | IEEE Trans on Sig- nal Processing2008，56，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员