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| 1 | Ehealth:Low FODMAP diet vs Lactobacillus rhamnosus GG in irritable bowel syndrome显示文摘AIM:To investigate the effects of a low fermentable,oligosaccharides,disaccharides,monosaccharides and polyols diet(LFD)and the probiotic Lactobacillus rhamnosus GG(LGG)in irritable bowel syndrome(IBS).METHODS:Randomised,unblinded controlled trial on the effect of 6-wk treatment with LFD,LGG or a normal Danish/Western diet(ND)in patients with IBS fulfilling Rome III diagnostic criteria,recruited betweenNovember 2009 and April 2013.Patients were required to complete on a weekly basis the IBS severity score system(IBS-SSS)and IBS quality of life(IBS-QOL)questionnaires in a specially developed IBS web selfmonitoring application.We investigated whether LFD or LGG could reduce IBS-SSS and improve QOL in IBS patients.RESULTS:One hundred twenty-three(median age 37years,range:18-74 years),90(73%)females were randomised:42 to LFD,41 to LGG and 40 to ND.A significant reduction in mean±SD of IBS-SSS from baseline to week 6 between LFD vs LGG vs ND was revealed:133±122 vs 68±107,133±122 vs 34±95,P<0.01.Adjusted changes of IBS-SSS for baseline covariates showed statistically significant reduction of IBS-SSS in LFD group compared to ND(IBS-SSS score75;95%CI:24-126,P<0.01),but not in LGG compared to ND(IBS-SSS score 32;95%CI:18-80,P=0.20).IBS-QOL was not altered significantly in any of the three groups:mean±SD in LFD 8±18 vs LGG 7±17,LFD 8±18 vs ND 0.1±15,P=0.13.CONCLUSION:LFD is efficacious for patients with IBS. | Natalia Pedersen Nynne Nyboe Andersen Zsuzsanna Végh Lisbeth Jensen Dorit Vedel Ankersen Maria Felding Mette Hestetun Simonsen Johan Burisch Pia Munkholm | 2014 | World Journal of Gastroenterology2014，20，43： | 16 |
| 2 | Low-FODMAP diet reduces irritable bowel symptoms in patients with inflammatory bowel disease显示文摘AIM To investigate the effect of a low-FODMAP diet on irritable bowel syndrome(IBS)-like symptoms in patients with inflammatory bowel disease(IBD).METHODS This was a randomised controlled open-label trial of patients with IBD in remission or with mild-to-moderate disease and coexisting IBS-like symptoms(Rome III) randomly assigned to a Low-FODMAP diet(LFD) or a normal diet(ND) for 6 wk between June 2012 andDecember 2013. Patients completed the IBS symptom severity system(IBS-SSS) and short IBD quality of life questionnaire(SIBDQ) at weeks 0 and 6. The primary end-point was response rates(at least 50-point reduction) in IBS-SSS at week 6 between groups; secondary end-point was the impact on quality of life. RESULTS Eighty-nine patients, 67(75%) women, median age 40, range 20-70 years were randomised: 44 to LFD group and 45 to ND, from which 78 patients completed the study period and were included in the final analysis(37 LFD and 41 ND). There was a significantly larger proportion of responders in the LFD group(n = 30, 81%) than in the ND group(n = 19, 46%);(OR = 5.30; 95%CI: 1.81-15.55, P < 0.01). At week 6, the LFD group showed a significantly lower median IBSSSS(median 115; inter-quartile range [IQR] 33-169) than ND group(median 170, IQR 91-288), P = 0.02. Furthermore, the LFD group had a significantly greater increase in SIBDQ(median 60, IQR 51-65) than the ND group(median 50, IQR 39-60), P < 0.01.CONCLUSION In a prospective study, a low-FODMAP diet reduced IBS-like symptoms and increased quality of life in patients with IBD in remission. | Natalia Pedersen Dorit Vedel Ankersen Maria Felding Henrik Wachmann Zsuzsanna Végh Line Molzen Johan Burisch Jens Rikardt Andersen Pia Munkholm | 2017 | World Journal of Gastroenterology2017，23，18： | 15 |
| 3 | Ehealth monitoring in irritable bowel syndrome patients treated with low fermentable oligo-, di-, mono-saccharides and polyols diet显示文摘In the present study we report on changes in irritable bowel syndrome-severity scoring system(IBS-SSS)and irritable bowel syndrome-quality of life(IBS-QoL)in 19 IBS patients,aged 18 to 74 years(F/M:14/5),during 12 wk registering their symptoms on the webapplication(www.ibs.constant-care.dk).During a control period of the first 6-wk patients were asked to register their IBS-SSS and IBS-QoL on the web-application weekly without receiving any intervention.Thereafter,low fermentable oligo-,di-,mono-saccharides and polyols(FODMAP)diet(LFD)was introduced for the next6 wk while continuing the registration.Though a small sample size a significant improvement in disease activity(IBS-SSS)was observed during both the control period,median:278(range:122-377),P=0.02,and subsequently during the LFD period,median:151(range:29-334),P<0.01.The IBS-QoL solely changed significantly during the LFD period,median:67(37-120),P<0.01.The significant reduction in disease activity during the control period shows a positive effect of the web-application on IBS symptoms when presented as a'traffic light'.However adding the diet reduced IBSSSS to<150,inactive to mild symptoms.In the future results from larger scale trials are awaited. | Natalia Pedersen Zsuzsanna Vegh Johan Burisch Lisbeth Jensen Dorit Vedel Ankersen Maria Felding Nynne Nyboe Andersen Pia Munkholm | 2014 | World Journal of Gastroenterology2014，20，21： | 7 |
| 4 | Individualized home-monitoring of disease activity in adult patients with inflammatory bowel disease can be recommended in clinical practice: A randomized-clinical trial显示文摘BACKGROUND The optimal way to home-monitor patients with inflammatory bowel disease(IBD)for disease progression or relapse remains to be found.AIM To determine whether an electronic health(eHealth)screening procedure for disease activity in IBD should be implemented in clinical practice,scheduled every third month(3M)or according to patient own decision,on demand(OD).METHODS Adult IBD patients were consecutively randomized to 1-year open-label eHealth interventions(3M vs OD).Both intervention arms were screening for disease activity,quality of life and fatigue and were measuring medical compliance with the constant care web-application according to the screening interventions OD or 3M.Disease activity was assessed using home measured fecal calprotectin(FC)and a disease activity score.RESULTS In total,102 patients were randomized(n=52/503M/OD)at baseline,and 88 patients completed the 1-year study(n=433M;n=45 OD).No difference in the two screening procedures could be found regarding medical compliance(P=0.58),fatigue(P=0.86),quality of life(P=0.17),mean time spent in remission(P>0.32),overall FC relapse rates(P=0.49),FC disease courses(P=0.61),FC time to a severe relapse(P=0.69)and remission(P=0.88)during 1 year.Median(interquartile range)numbers of FC home-monitoring test-kits used per patient were significantly different,3M:6.0(5.0-8.0)and OD:4.0(2.0-9.0),P=0.04.CONCLUSION The two eHealth screening procedures are equally good in capturing a relapse and bringing about remission.However,the OD group used fewer FC home testkits per patient.Individualized screening procedures can be recommended for adult IBD patients in clinical web-practice. | Dorit Vedel Ankersen Petra Weimers Dorte Marker Mette Bennedsen Sanaz Saboori Kristine Paridaens Johan Burisch Pia Munkholm | 2019 | World Journal of Gastroenterology2019，25，40： | 2 |
| 5 | Simple method to determine hita-lactam resistance phenotypes in Pseudornonas in Pseudomomas aeruginosa using the disc agar diffusion test显示文摘 | Vedel G | 2005 | J Antimicrob Chemother2005，56，4： | 1 |
| 6 | Intracortical multiplesclerosis lesions are not associatecd with increased lymphocyteinfiltration显示文摘 | Bo L Vedeler C A Nyland H | 2003 | Mult Scler2003，9，4： | 1 |
| 7 | Fc receptors for immunoglobulin G:a role in the pathogenesis of Guillain Barrie syndrome and multiple sclerosis显示文摘 | Myhr KM Nyland H | 2001 | J Neuroimmunol2001，118，2： | 1 |
| 8 | Differential activation of motor units in the wrist extensor muscles during the tonic vibration reflex in man 显示文摘 | ROMAIGUERE P VEDEL J P AZULAY J P | 1991 | J Physiol1991，，444： | 1 |
| 9 | Plasmid mediated car bapenem-hydrolyzing β-lactamase KPC in a Klebsiella pneumoniae isolate from Franee显示文摘 | Naas T Nordmann P Vedel G | 2005 | Antimicrob Agents Chemoth er2005，49，10： | 1 |
| 10 | Intergeneric cytoplasmic hybridization in Crucfferae by protoplast fusion显示文摘 | Pelletier G Primard C Vedel F | 1983 | Molecular General Genetics1983，191，： | 1 |
| 11 | Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes显示文摘 | Gaede P Vedel P Larsen N | | 0，，05： | 1 |
| 12 | Deletion of the last two exons of the mitochondrialnad7 gene results in lack of the NAD7 polypeptide in aNicotiana sylvestris CMS mutant显示文摘 | Magali Pla Chantal Mathieu Rosine Paepe Philippe Chétrit Fernand Vedel | 1995 | MGG Molecular & General Genetics1995，，1： | 1 |
| 13 | Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes显示文摘 | Gaede P Vedel P Larsen N | 2003 | N Engl J Med2003，348，5： | 1 |
| 14 | Multifactorial interventionand cardiovascular disease in patients with type 2 diabetes显示文摘 | Gaede P Vedel P Larsen N | 2003 | N Engl J Med2003，348，5： | 1 |
| 15 | Simple method to determine lactam resistance phenotypes in Pseudomonas aeruginosa using the disc agar diffusion test显示文摘 | Vedel G | 2005 | Journal of Antimicrobial Chemotherapy2005，56，4： | 1 |
| 16 | Specific cleavage of chloroplast DNA from higher plants by EcoRI restriction nuclease 显示文摘 | Vedel P Quetier F Bayen M | 1976 | Nature1976，263，： | 1 |
| 17 | Electrodeposition and characterization of cuInSe2 thin films 显示文摘 | THOUIN L VEDEL J | 1995 | J Electrochem Soc1995，142，9： | 1 |
| 18 | Plasmid mediated carbapenemhydrolyzing β-lactamase KPC in a Klebsiella pneumoniae isolate from France显示文摘 | Naas T Nordmann P Vedel G et a1 | | 0，，10： | 1 |
| 19 | Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes显示文摘 | G(e)de P Vedel P Larsen N Jensen GVH Parving HH Pederson O | 2003 | N Engl J Med2003，348，5： | 1 |
| 20 | Multifactorial intervention andcardiovascular disease in patients with type 2 diabetes 显示文摘 | Gaede P Vedel P Larsen N | 2003 | N Engl JMed2003，348，5： | 1 |
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