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| 1 | Diabetic cardiomyopathy:Pathophysiology,diagnostic evaluation and management显示文摘Diabetes affects every organ in the body and cardiovascular disease accounts for two-thirds of the mortality in the diabetic population.Diabetes-related heart disease occurs in the form of coronary artery disease(CAD),cardiac autonomic neuropathy or diabetic cardiomyopathy(DbCM).The prevalence of cardiac failure is high in the diabetic population and DbCM is a common but underestimated cause of heart failure in diabetes.The pathogenesis of diabetic cardiomyopathy is yet to be clearly defined.Hyperglycemia,dyslipidemia and inflammation are thought to play key roles in the generation of reactive oxygen or nitrogen species which are in turn implicated.The myocardial interstitium undergoes alterations resulting in abnormal contractile function noted in DbCM.In the early stages of the disease diastolic dysfunction is the only abnormality,but systolic dysfunction supervenes in the later stages with impaired left ventricular ejection fraction.Transmitral Doppler echocardiography is usually used to assess diastolic dysfunction,but tissue Doppler Imaging and Cardiac Magnetic Resonance Imaging are being increasingly used recently for early detection of DbCM.The management of DbCM involves improvement in lifestyle,control of glucose and lipid abnormalities,and treatment of hypertension and CAD,if present.The role of vasoactive drugs and antioxidants is being explored.This review discusses the pathophysiology,diagnostic evaluation and management options of DbCM. | Joseph M Pappachan George I Varughese Rajagopalan Sriraman Ganesan Arunagirinathan | 2013 | World Journal of Diabetes2013，4，5： | 57 |
| 2 | Phenylboronic acids in crystal engineering:Utility of the energetically unfavorable syn,syn-conformation in co-crystal design显示文摘原则上, Phenylboronic 酸能在三不同 conformers 存在(syn, syn;syn,反和反,反) 与不同精力侧面。处于他们的本国的状态,这些混合物比较喜欢精力充沛地赞成的 syn,反符合构造。在分子的建筑群,然而,功能展出 conformational 差异。与 N 施主混合物,在我们报导的这份报纸,一系列合作水晶由基于 syn 包含 synthons 的设计策略准备了, boronic 酸功能的 syn 符合构造。为这个目的,我们与 1,2-diazo 碎片(alprazolam, 1H-tetrazole, acetazolamide 和 benzotriazole ) 采用了混合物,为共结晶的 1,10-phenanthroline 和 2,2-bipyridine 试验。然而,我们的学习证明在 coformer 的 1,2-diazo 碎片的仅仅的存在不与 syn 保证合作水晶的成功的形成, boronic 酸的 syn 符合构造。 | VARUGHESE Sunil SINHA Shashi Bhushan DESIRAJU Gautam R. | 2011 | Science China Chemistry2011，54，12： | 2 |
| 3 | 质量改进科学在麻醉学科的植入和发展显示文摘距离美国医学研究所质量报告的发布时间已经过去20年,医疗管理在质量控制、患者安全和流程改进等领域取得了一定的进步。然而,着眼于全球,这一概念仍处于起步阶段。将质量管理科学植入医疗领域,必须根据其特点进行定义、测量和分析,并合理使用质量改进框架和工具。麻醉学科一直是临床医疗质量和安全的领先专业,质量改进科学直接影响了麻醉学科的发展。本文介绍了质量改进科学的基本概念和方法,以及其在麻醉学科中的植入和发展,并以临床实例展示质量改进的过程和结果。 | 许文妍 Varughese Anna Mary 张马忠 | 2021 | 上海医学2021，44，3： | 2 |
| 4 | Thermal and crystallization behaviour of isotaetie polypropylene/nitrile rubber blends 显示文摘 | George S Varughese K T Thomas S | 2000 | Polymer2000，41，： | 1 |
| 5 | Thermo- gravimetric and wide angle X-ray diffraction analysis of ther- moplastic elastomers from nylon copolymer and EPDM rub- ber显示文摘 | Komalan C George K E Varughese K T | 2008 | Polymer Degradation and Stability2008，93，12： | 1 |
| 6 | Antibiotic-associated diarrhea:a refresher on causes and possible prevention with probiotics-continuing education article显示文摘 | Varughese CA Vakil NIL Phillips KM | 2013 | J Pharm Pract2013，26，5： | 1 |
| 7 | Antibiotic - asso- ciated diarrhea: a refresher on causes and possible prevention with probiotics - -continuing education article 显示文摘 | Varughese C A Vakil N H Phillips K M | 2013 | J Pharm Pract2013，26，5： | 1 |
| 8 | Colchicine in acute gout显示文摘 | Morris I Varughese G Mattingly P | 2003 | BMJ2003，327，7426： | 1 |
| 9 | Pt'Cu core-shell and alloy nanoparticles for heterogeneousNO: reduction: Anomalous stability and reactivity of a core-shell nanostructure显示文摘 | Zhou S H Varughese B Eichhorn B | 2005 | Angexvandte Chemie-International Edition2005，44，29： | 1 |
| 10 | A paradigm shift in the treatment of advanced non-small cell lung cancer显示文摘 | Varughese S Jahangir KS Simpson CE | 2012 | Am J Med Sci2012，344，2： | 1 |
| 11 | Lymphocyte recruit-ment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent显示文摘 | Galkina E Kadl A Sanders J Varughese D Sarembock IJ Ley K | 2006 | J Exp Med2006，203，5： | 1 |
| 12 | Antibiotic-associated diarrhea: arefresher on causes and possible prevention with probiotics--continuingeducation article显示文摘 | Varughese CA Vakil NH Phillips KM | 2013 | J Pharm Pract2013，26，5： | 1 |
| 13 | Magnetic Iron Oxide Nanoparticles for Biorecognition: Evaluation of Surface Coverage and Activity显示文摘 | KOH I WANG X VARUGHESE B | 2006 | Phys Chem B2006，110，： | 1 |
| 14 | An ethnopharmacological survey for potential angiotensin converting enzyme inhibitors from Indian medicinal plants 显示文摘 | Somanadhan B Varughese G Palpu P | 1999 | J Ethnopharmacol1999，65，： | 1 |
| 15 | Evaluation using extracted human teeth of Ricetral as a storage medium for avulsions-an in vitro study显示文摘 | Rajendran P Varghese NO Varughese JM | 2011 | Dent Traumatol2011，27，3： | 1 |
| 16 | Factors Influencing Posttransplantation Employment: Does Depression Have an Impact?显示文摘 | E. Gorevski P. Succop J. Sachdeva R. Scott J. Benjey G. Varughese J. Martin-Boone | 2011 | Transplantation Proceedings2011，，10： | 1 |
| 17 | Colchicine in acute gout显示文摘 | Morris J Varughese G Mattingly P | 2003 | BMJ2003，327，： | 1 |
| 18 | Permissive hypercapnia in neonates :The case of the good the bad ,and the ugly显示文摘 | Varughese M Patole S Shama A | 2002 | Pediatr Pulmonol2002，33，1： | 1 |
| 19 | Molecular dynamics studies on troponin (TnI-TnT-TnC) complexes:insight into the regulation of muscle contraction显示文摘 | Varughese J F Chalovich J M Li Y | 2010 | J Biomol Struct Dyn2010，28，2： | 1 |
| 20 | 显示文摘 | Zhou S Varughese B Eiehhorn B | 2005 | Angewandte Che- mie2005，117，29： | 1 |
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