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| 1 | Importance of gastrin in the pathogenesis and treatment of gastric tumors显示文摘In addition to regulating acid secretion, the gastric antral hormone gastrin regulates several important cellular processes in the gastric epithelium including proliferation, apoptosis, migration, invasion, tissue remodelling and angiogenesis. Elevated serum concentrations of this hormone are caused by many conditions, particularly hypochlorhydria (as a result of autoimmune or Helicobacter pylori (H pylori)-induced chronic atrophic gastritis or acid suppressing drugs) and gastrin producing tumors (gastrinomas). There is now accumulating evidence that altered local and plasma concentrations of gastrin may play a role during the development of various gastric tumors. In the absence of H pylori infection, marked hypergastrinemia frequently results in the development of gastric enterochromaffi n cell-like neuroendocrine tumors and surgery to remove the cause of hypergastrinemia may lead to tumor resolution in this condition. In animal models such as transgenic INS-GAS mice, hypergastrinemia has also been shown to act as a cofactor with Helicobacter infection during gastric adenocarcinoma development. However, it is currently unclear as to what extent gastrin also modulates human gastric adenocarcinoma development. Therapeutic approaches targeting hypergastrinemia,such as immunization with G17DT, have been evaluated for the treatment of gastric adenocarcinoma, with some promising results. Although the mild hypergastrinemia associated with proton pump inhibitor drug use has been shown to cause ECL-cell hyperplasia and to increase H pylori-induced gastric atrophy, there is currently no convincing evidence that this class of agents contributes towards the development of gastric neuroendocrine tumors or gastric adenocarcinomas in human subjects. | Michael D Burkitt Andrea Varro D Mark Pritchard | 2009 | World Journal of Gastroenterology2009，15，1： | 36 |
| 2 | Hypergastrinemiaincreases gastric epithelial susceptibility to apoptosis显示文摘 | Przemeck SM Varro A Berry D | 2008 | Regul Pept2008，14，6： | 1 |
| 3 | Helicobacter pylori induces plasminogen activator inhibitor 2 in gastric epithelial cells through nuclear factor-kappaB and RhoA: implications for invasion and apoptosis显示文摘 | Varro A Noble P J Pritchard D M | 2004 | Cancer Res2004，64，5： | 1 |
| 4 | Sodium calcium exchange as a tar- get for antiarrhythmic therapy 显示文摘 | Sipido KR Varro A Eisner D | 2006 | Handb Exp Pharmacol2006，171，： | 1 |
| 5 | UML action semantics for model transformation systems显示文摘 | Varro D Pataricza A | 2003 | Periodica Polytechnica2003，47，3： | 1 |
| 6 | Estimate of net calcium fluxes and sarcoplasmic reticulum calcium content during systole in rat ventricular myocytes显示文摘 | Negretti N Varro A Eisner D A | 1995 | J Physiol (Lond)1995，486，： | 1 |
| 7 | Designing the automatic transformation of visual languages显示文摘 | Varro D Varro G Pataricza A | 2002 | Science of Computer Programming2002，44，2： | 1 |
| 8 | Identification of plasminogen activator inhibitor-2 as a gastrin-regulated gene: role of rho GTPase and menin 显示文摘 | Hemers E Archer D | 2002 | Gastroenterology2002，123，： | 1 |
| 9 | Idetification of plasminogen activator inhibitor - 2 as a gastrin - regulated gene: Role of Rho GTPase and menin 显示文摘 | Hemers E Archer D | 2002 | Gastroenterology2002，123，1： | 1 |
| 10 | Hypergastrinemia increases gastric epithelial susceptibility to apoptosis 显示文摘 | Prezemeck SM Varro A Berry D | 2008 | Regul Pept2008，14，6： | 1 |
| 11 | Designing the automatic transformation of visual languages 显示文摘 | Varro D Varro G Pataricza A | 2002 | Science of Computer Programming2002，44，2： | 1 |
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