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| 1 | Atrial fibrillation in patients with gastroesophageal reflux disease: A comprehensive review显示文摘AIM:To analyze the potential relationship between gastroesophageal reflux disease(GERD)and the development of atrial fibrillation(AF).METHODS:Using the key words'atrial fibrillation and gastroesophageal reflux','atrial fibrillation and esophagitis,peptic','atrial fibrillation and hernia,hiatal'the PubMed,EMBASE,Cochrane Library,OVIDSP,WILEY databases were screened for relevant publications on GERD and AF in adults between January 1972-December 2013.Studies written in languages other than English or French,studies not performed in humans,reviews,case reports,abstracts,conference presentations,letters to the editor,editorials,comments and opinions were not taken into consideration.Articles treating the subject of radiofrequency ablation of AF and the consecutive development of GERD were also excluded.RESULTS:Two thousand one hundred sixty-one titles were found of which 8 articles met the inclusion criteria.The presence of AF in patients with GERD was reported to be between 0.62%-14%,higher compared to those without GERD.Epidemiological data provided by these observational studies showed that patients with GERD,especially those with more severe GERD-related symptoms,had an increased risk of developing AF compared with those without GERD,but a causal relationship between GERD and AF could not be established based on these studies.The mechanisms of AF as a consequence of GERD remain largely unknown,with inflammation and vagal stimulation playing a possible role in the development of these disorders.Treatment with proton pomp inhibitors may improve symptoms related to AF and facilitate conversion to sinus rhythm.CONCLUSION:Although links between AF and GERD exist,large randomized clinical studies are required for a better understanding of the relationship between these two entities. | Crina Roman Stanislas Bruley des Varannes Lucian Muresan Alina Picos Dan L Dumitrascu | 2014 | World Journal of Gastroenterology2014，20，28： | 16 |
| 2 | Rabeprazole test for the diagnosis of gastro-oesophageal reflux disease: Results of a study in a primary care setting显示文摘瞄准:为了决定病人的 rabeprazole 测试的诊断价值,由全科医生看。方法:有 GERD 暗示的症状的 83 个病人被全科医生在这个多中心注册,使随机化并且双窗帘学习。所有病人收到了 rabeprazole (20 mg 出价) 或安慰剂一个星期。GERD 的诊断在内视镜检查法或反常食道的 24-h pH 测试在粘膜裂缝的存在上被建立。如果病人们报导至少,“ 7 点 Likert 上的症状的清楚的改进”可伸缩,测试被认为阳性。结果:为 rabeprazole 和安慰剂的测试的敏感分别地是 83% 和 40% 。相应特性,积极、否定的预兆的价值是 45% 和 67% , 71% 和 71% ,和 62% 和 35% 分别地。操作特征(巨鸟) 分析的接收装置证实最好差别对待截止对应于对“清楚的改进”的描述。结论:禁止者(PPI ) 测试的质子泵的差的特性不支持如此的一条途径在一个主要照顾背景建立 GERD 的诊断。 | Stanislas Bruley des Varannes Sylvie Sacher-Huvelin Fabienne Vavasseur Claude Masliah Marc Le Rhun Philippe Aygalenq Sylvie Bonnot-Marlier Yves Lequeux Jean Paul Galmiche | 2006 | World Journal of Gastroenterology2006，12，16： | 4 |
| 3 | 失弛缓症患者血清可改变正常人胃底肠肌间神经丛化学信号和NO介导的反应显示文摘Background and aims: Achalasia is a disease of unknown aetiology. An immune mechanism has been suggested on the basis of previous morphological observations. The objective of this study was to test whether the serum of achalasia patients could reproduce the phenotype and functional changes that occur with disease progression in an ex vivo human model. Methods: Specimens of normal human fundus were maintained in culture in the presence of serum from patients with achalasia, gastro-oesophageal reflux disease (GORD), or healthy subjects (controls). Immunohistochemical detection of choline acetyltransferase (ChAT), neurone specific enolase (NSE), vasoactive intestinal polypeptide (VIP), nitric oxide synthase (NOS), and substance P was carried out in whole mounts of gastric fundus myenteric plexus. In addition, the effects of achalasia serum on electrical field stimulation (EFS) induced contractions were measured in circular muscle preparations. Results: Serum from achalasia patients did not affect the number of myenteric neurones. Tissues incubated with serum from achalasia patients showed a decrease in the proportion of NOS (- 26% of NSE positive neurones; p = 0.016) and VIP (- 54% ; p = 0.09) neurones, and a concomitant increase in ChAT neurones (+ 16% ; p< 0.001) compared with controls. In contrast, GORD serum did not modify the phenotype of myenteric neurones. Area under the curve of EFS induced relaxations (abolished by N-nitro-L-arginine methyl ester) was significantly decreased following incubation with serum from achalasia patients compared with controls (- 7.6 (2.6) v - 14.5 (5.0); p = 0.036). Conclusions: Serum from achalasia patients can induce phenotypic and functional changes which reproduce the characteristics of the disease. Further identification of putative seric factors and mechanisms involved could lead to the development of novel diagnostic and/or therapeutic strategies in achalasia. | Bruley Des Varannes S. Chevalier J. Pimont S. M. Neunlist 程妍(译) 陈云茹(校) | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，2，8： | 3 |
| 4 | Tenatoprazole,a novel proton pump inhibitor with a pro- longed plasma half-life: effects on intragastric pH andcomparison with esomeprazole in healthy volunteers 显示文摘 | Galmiche J P Bruley Des Varannes S Ducrotte P | 2004 | Aliment Pharma Ther2004，19，6： | 1 |
| 5 | Reflux related symptoms in patients with normal oesophageal exposure acid显示文摘 | Shi G Bruley des Varannes S Scarpignato C | 1995 | Gut1995，37，4： | 1 |
| 6 | Colonic bi- opsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms显示文摘 | Lebouvier T Neunlist M Bruley des Varannes S | 2010 | PLoS One2010，5，12： | 1 |
| 7 | Erythromycin enhances fasting and postp randial proximal gastric tone in humans显示文摘 | Bruley des Varannes S Parys V Ropert A | 1995 | Gastroenterology1995，109，1： | 1 |
| 8 | A comparative study of the early effects of tenatoprazole 40 mg and esomeprazole 40mg on intragastric pH in healthy volunteers显示文摘 | Galmiche JP Sacher-Huvelin S Bruley des Varannes S | | 0，，： | 1 |
| 9 | Two thirds of patients with gastroesophageal reflux have nocturnal symptoms= survey by 562 general practi tioners of 36663 patients显示文摘 | Bruley des Varannes S Errieau G Tessier C | 2007 | Presse Med2007，36，41： | 1 |
| 10 | Tenatoprazole,a novel proton pump inhibitor with a prolonged plasma half-life:effects on intragastric pH and comparison with esomeprazole in healthy volunteers显示文摘 | Galmiche JP Bruley Des Varannes S Ducrotté P | | 0，，： | 1 |
| 11 | Endogenous cholecystokinin in postprandial lower esophageal sphincter function and fundie tone in humans 显示文摘 | Zerbib F Bruley Des Varannes S | 1998 | Am J Physiol1998，275，61： | 1 |
| 12 | Respiratory manifestations of gastro- oesophageal reflux disease显示文摘 | GALMICHE J P ZERBIB F BRULEY DES VARANNES S | 2008 | Aliment Pharmacol Ther2008，27，： | 1 |
| 13 | Proximal gastric tone in gastro-oesophageal reflux disease 显示文摘 | Des Varannes SB Ropert A Lamouliatte H Quinton A Galmiche JP | 1999 | Eur J Gastroenterol Hepatol1999，11，5： | 1 |
| 14 | Serum from achalasia patients alters neurochemical coding in the myenteric plexus and nitric oxide mediated motor response in normal human fundus显示文摘 | Bruley des Varannes S Chevalier J pimont S | 2006 | Gut2006，55，3： | 1 |
| 15 | Endoscopy-negative reflux disease显示文摘 | Galmiche JP des Varannes SB | 2001 | Curr Gastroenterol Rep2001，3，3： | 1 |
| 16 | Simultaneous recordings of oesophageal acid exposure with conventional pH monitoring and a wireless system (Bravo) 显示文摘 | Des Varannes SB Mion F Ducrotte P | 2005 | Gut2005，54，12： | 1 |
| 17 | Cost and burden of gastroesophageal reflux disease a- mong patients with persistent symptoms despite proton pump inhibitor therapy: an observational study in France 显示文摘 | Varannes SB LOfman HG Karlsson M | 2013 | BMC Gastroenterology2013，13，1： | 1 |
| 18 | Colonic biopsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms显示文摘 | Lebouvier T Neunlist M Bruley des Varannes S | 2010 | PLoS One2010，5，12： | 1 |
| 19 | Normal values and day‐to‐day variability of 24‐h ambulatory oesophageal impedance‐pH monitoring in a Belgian–French cohort of healthy subjects显示文摘 | F.ZERBIB S.BRULEY DES VARANNES S.ROMAN P.POUDEROUX F.ARTIGUE U.CHAPUT F.MION F.CAILLOL E.VERIN G.BOMMELAER P.DUCROTTé J.‐P.GALMICHE D.SIFRIM | 2005 | Alimentary Pharmacology & Therapeutics2005，，10： | 1 |
| 20 | 显示文摘 | Lartigue S Bizais Y des Varannes SB | 1994 | Dig Dis Sci1994，39，： | 1 |
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