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| 1 | Otitis media with effusion in children: Pathophysiology, diagnosis, and treatment.A review显示文摘Otitis media with effusion(OME)is a frequent paediatric disorder.The condition is often asymptomatic,and so can easily be missed.However,OME can lead to hearing loss that impairs the child's language and behavioural development.The diagnosis is essentially clinical,and is based on otoscopy and(in some cases)tympanometry.Nasal endoscopy is only indicated in cases of unilateral OME or when obstructive adenoid hypertrophy is suspected.Otitis media with effusion is defined as the observation of middle-ear effusion at consultations three months apart.Hearing must be evaluated(using an age-appropriate audiometry technique)before and after treatment,so as not to miss another underlying cause of deafness(e.g.perception deafness).Craniofacial dysmorphism,respiratory allergy and gastro-oesophageal reflux all favour the development of OME.Although a certain number of medications(antibiotics,corticoids,antihistamines,mucokinetic agents,and nasal decongestants)can be used to treat OME,they are not reliably effective and rarely provide long-term relief.The benchmark treatment for OME is placement of tympanostomy tubes(TTs)and(in some cases)adjunct adenoidectomy.The TTs rapidly normalize hearing and effectively prevent the development of cholesteatoma in the middle ear.In contrast,TTs do not prevent progression towards tympanic atrophy or a retraction pocket.Adenoidectomy enhances the effectiveness of TTs.In children with adenoid hypertrophy,adenoidectomy is indicated before the age of 4 but can be performed later when OME is identified by nasal endoscopy.Children must be followed up until OME has disappeared completely,so that any complications are not missed. | Pauline Vanneste Cyril Page | 2019 | Journal of Otology2019，14，2： | 19 |
| 2 | Osmotic Stress Modulates the Balance between Exocytosis and Clathrin-Mediated Endocytosis in Arabidopsis thaliana显示文摘植物的无柄的生活方式创造需要处理经常不利的环境,在水,可获得性能在一个每日的基础上变化,质问细胞的生理学和正直。处于渗透的条件的变化破坏血浆膜的平衡:hypoosmotic 条件 increaseand hyperosmotic 环境减少房间卷。这里,我们证明短期的细胞外的渗透的处理被移动仔细在根分裂组织房间处于在 endocytosis 和 exocytosis 之间的平衡跟随。尖锐 hyperosmotic 处理(离子并且 nonionic ) 同时提高调停 clathrin 的 endocytosis attenuating exocytosis,而 hypoosmotic 处理有相反的效果。除了到血浆膜的 clathrin 招募,早 endocytic trafficking 的部件在 hyperosmotic 压力回答期间是必要的。因而,在 clathrin 或早 endocytic 机械的元素有缺点的幼苗的生长对 hyperosmotic 处理更敏感。我们也发现对在环境的渗透的地位的一个变化的 endocytotic 反应在植物荷尔蒙的大概进化的更最近的规章的效果上是主导的,例如植物生长素。这些结果暗示那渗透的不安影响在通过调停 clathrin 的 endocytosis 行动的 endocytosis 和 exocytosis 之间的平衡。我们建议血浆膜上的那紧张在房间表面决定膜的增加或移动,因此保存房间正直。 | Marta Zwiewka Tomasz Nodzynski Stephanie Robert Steffen Vanneste Jiri Friml | 2015 | Molecular Plant2015，8，8： | 5 |
| 3 | Role of perinatal long-chain omega-3 fatty acids in cortical circuit maturation:Mechanisms and implications for psychopathology显示文摘Accumulating translational evidence suggests that the long-chain omega-3 fatty acid docosahexaenoic acid(DHA) plays a role in the maturation and stability of cortical circuits that are impaired in different recurrent psychiatric disorders. Specifically, rodent and cell culture studies find that DHA preferentially accumulates in synaptic and growth cone membranes and promotes neurite outgrowth, dendritic spine stability, and synaptogenesis. Additional evidence suggests that DHA may play a role in microglia-mediated synaptic pruning, as well as myelin development and resilience. In nonhuman primates n-3 fatty acid insufficiency during perinatal development leads to widespread deficits in functional connectivity in adult frontal cortical networks compared to primates raised on DHA-fortified diet. Preterm delivery in non-human primates and humans is associated with early deficits in cortical DHA accrual. Human preterm birth is associated with longstanding deficits in myelin integrity and cortical circuit connectivity and increased risk for attention deficit/hyperactivity disorder(ADHD), mood, and psychotic disorders. In general, ADHD and mood and psychotic disorders initially emerge during rapid periods of cortical circuit maturation and are characterized by DHA deficits, myelin pathology, and impaired cortical circuit connectivity. Together these associations suggest that early and uncorrected deficits in fetal brain DHA accrual may represent a modifiable risk factor for cortical circuit maturation deficits in psychiatric disorders, and could therefore have significant implications for informing early intervention and prevention strategies. | Robert K McNamara Jennifer J Vannest Christina J Valentine | 2015 | World Journal of Psychiatry2015，5，1： | 2 |
| 4 | Guiding adult Mammalian sensory axons during regeneration 显示文摘 | Webber CA Xu Y Vanneste KJ | 2008 | J Neuropathol Exp Neurol2008，67，3： | 1 |
| 5 | Maintenance optimization of a production system with buffer capacity 显示文摘 | Schouten F A V D Vanneste S G | 1995 | European Journal of Operational Research1995，82，2： | 1 |
| 6 | Transient alcohol craving suppression by rTMS of dorsal anterior cingulate: an fMRI and LORETA EEG study显示文摘 | De Ridder D Vanneste S Kovaes S | 2011 | Neurosci Lett2011，496，： | 1 |
| 7 | Submarine mass movements on glaciated and non-glaciated European continental margins: A review of triggering mechanisms and preconditions to failure显示文摘 | Leynaud D Mienert J Vanneste M | 2009 | Marine and Petroleum Geology2009，26，5： | 1 |
| 8 | Excitatory repetitive transcranial magnetic stimulation induces improvements in chronic poststroke aphasia显示文摘 | Szaflarski JP Vannest J Wu SW | 2011 | Med Sci Monit2011，17，3： | 1 |
| 9 | Exponentially small inertia gravity waves and the breakdown of quasigeostrophic balance显示文摘 | Vanneste J Yavneh I | 2004 | Journal of the Atmospheric Sciences2004，61，2： | 1 |
| 10 | Optimized simultaneous ASL and BOLD functional imaging of the whole brain显示文摘 | Schmithorst VJ Hernandez-Garcia L Vannest J | 2014 | J Magn Reson Imaging2014，39，： | 1 |
| 11 | Fever of unknown origin in the 1980s:an update of the diagnostic spectrum显示文摘 | Knockaert DC Vanneste LJ Vanneste SB | 1992 | Arch Intern Med1992，152，1： | 1 |
| 12 | Effects of cyclic lateral loads on piles in sand显示文摘 | Long J H Vanneste G | 1994 | ASCE J Geotech Eng ASCE1994，120，1： | 1 |
| 13 | Ocean warming and gas hydrate stability on the mid-norwegian margin at the Storegga Slide显示文摘 | Mienert J Vanneste M Bünz S | 2005 | Marine and Petroleum Geology2005，22，1： | 1 |
| 14 | Jejunal cholinergic, nitrergic, and soluble guanylate cyclase activity in postoperative ileus显示文摘 | Vanneste G van Nassauw L Kalfin R | 2008 | Surgery2008，144，3： | 1 |
| 15 | Transcutaneous electrical nerve stimulation (TENS) of upper cervical nerve (C2) for the treatment of somatic tinnitus 显示文摘 | Vanneste S Plazier M van de Heyning P | 2010 | Exp Brain Res2010，204，2： | 1 |
| 16 | Health effects of improved meal ambiance in a Dutch nursing home: a 1 - year intervention study 显示文摘 | Mathey M Vanneste V de Gr'aaf C | 2001 | Preventive Medicine2001，32，5： | 1 |
| 17 | Fever of unknown origin in the elderly patients显示文摘 | Knockaert DC Vanneste LJ Bobbaers HJ | 1993 | J Am Geriatr Soc1993，41，11： | 1 |
| 18 | Auxin-mediated cell cycle activation during early lateral root initiation显示文摘 | Himanen K Boucheron E Vanneste S | 2002 | The plant cell2002，14，： | 1 |
| 19 | Excitatory repetitive transcranial magnetic stimulation induces improvements in chronic post-stroke aphasia 显示文摘 | Szaflarski JP Vannest J Wu SW | 2011 | Med Sci Monit2011，17，3： | 1 |
| 20 | Performances des system, de vision nocturne passive utilisant des tubes intensificateurs d' images influence de la response spectrale de la photocathode显示文摘 | J C Richard D L Lamport E Roaux C Vanneste | 1977 | Acta Electronica1977，20，： | 1 |
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