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| 1 | MicroRNA signatures in chemotherapy resistant esophageal cancer cell lines显示文摘AIM:To investigate expression of microRNA(miRNA)and potential targets in chemotherapy resistant esoph-ageal cancer cell lines.METHODS:An in-vitro model of acquired chemotherapy resistance in esophageal adeno-(EAC)and squamous cell carcinoma(ESCC)cells was used,and microRNA expression profiles for cisplatin or 5-fluorouracil(5-FU)resistant variants vs chemotherapy sensitive controls were compared using microarray and quantitative real-time polymerase chain reaction(PCR).The expression of chemotherapy-relevant genes potentially targeted by the dysregulated microRNAs in the chemotherapy resistant variants was also evaluated.RESULTS:Chemotherapy resistant sublines were found to have specific miRNA signatures,and these miRNA signatures were different for the cisplatin vs 5-FU resistant cells from the same tumor cell line,and also for EAC vs ESCC cells with resistance to the same specific chemotherapy agent.Amongst others,miR-27b-3p,miR-193b-3p,miR-192-5p,miR-378 a-3p,miR-125a-5p and miR-18a-3p were dysregulated,consistent with negative posttranscriptional control of KRAS,TYMS,ABCC3,CBL-B and ERBB2 expression via these miRNAs.CONCLUSION:The current study supports the hypothesis that microRNA expression has an impact on chemotherapy resistance in esophageal cancer. | Richard Hummel Corina Sie David I Watson Tingting Wang Alfiya Ansar Michael Z Michael Mark Van der Hoek Joerg Haier Damian J Hussey | 2014 | World Journal of Gastroenterology2014，20，40： | 8 |
| 2 | ESPEN Guidelines on Enteral Nutrition: Non-surgical oncology显示文摘 | J. Arends G. Bodoky F. Bozzetti K. Fearon M. Muscaritoli G. Selga M.A.E. van Bokhorst-de van der Schueren M. von Meyenfeldt G. Zürcher R. Fietkau E. Aulbert B. Frick M. Holm M. Kneba H.J. Mestrom A. Zander | 2006 | Clinical Nutrition2006，，2： | 6 |
| 3 | Detailed measurements of local heat transfer coefficient and adiabatic wall temperature beneath an array of impingement jets 显示文摘 | Van Treuren K Wang Z Ireland P et aI | 1995 | Journal of Turbomachinery1995，116，2： | 1 |
| 4 | Development of approaches to improve cell survival in myoblast transfer therapy显示文摘 | Balkir L van Deutekom JCT | 1998 | J Cell Biol1998，142，： | 1 |
| 5 | The cell cycle:a review of regulation, deregulation and therapeutic targets in cancer 显示文摘 | Vermeulen K Van Bockstaele D R Berneman Z N | 2003 | Cell Prolif2003，，16： | 1 |
| 6 | Roflumi last, an oral, oncedaily phosphodiesterase 4 inhibitor, attenu- ates allergen induced asthmatic reactions显示文摘 | Van Schalkwyk E Strydom K Williams Z | 2005 | J Allergy Clin Immunol2005，116，2： | 1 |
| 7 | Immunomodulation of activated hepatic stel ate cel s by mesenchymal stem cel s显示文摘 | Parekkadan B van Pol D Megeed Z | | 0，，02： | 1 |
| 8 | Using poultry littcr biocbars as rail amendments显示文摘 | Cban K Y Van Z L Meszaros I | 2008 | Australian Journal of Soil Rescarch2008，46，： | 1 |
| 9 | Implantable cardioverter deft- brillator therapy in adults with congenital heart disease :who is at risk of shocks?显示文摘 | Koyak Z de Groot JR Van Gelder 1C | 2012 | Circ Arrhythm Electrophysiol2012，5，1： | 1 |
| 10 | SIRT6 overexpression induces massive apoptosis in cancer cells but not in norm~ cells 显示文摘 | Van Meter M Mao Z Gorbunova V | 2011 | Cell Cycle2011，10，18： | 1 |
| 11 | T-helper 17 cell cytokines and interferon type I: partners in crime in systemic lupus erythematosus? 显示文摘 | Brkic Z Cometh OB van Helden-Meeuwsen CG | 2014 | Arthritis Res Ther2014，16，2： | 1 |
| 12 | Improving chlorine dioxide bleaching with aldehydes显示文摘 | Jiang Z H Lierop B Van Berry R | 2007 | JPPS2007，33，2： | 1 |
| 13 | Development of approa-ches to improve cell survival in myoblast transfer therapy显示文摘 | Qu z Balkir L van Deutekom JC | 1998 | J Cell Biol1998，142，5： | 1 |
| 14 | Industrial ecology framework for achieving cleaner production in the mining and minerals industry 显示文摘 | Arun J B Dirk J A van Z | 2006 | Journal of Cleaner Production2006，，34： | 1 |
| 15 | Pre-B-cell colony-enhancing factor regulates NAD+-dependent protein deacetylase activity and promotes vascular smooth muscle cell maturation显示文摘 | van der Veer E Nong Z O′Neil C | 2005 | Circ Res2005，97，1： | 1 |
| 16 | Increased Ca2+-sensitivity of the contractile apparatus in end-stage human heart failure results from altered phosphorylation of contractile proteins显示文摘 | van der Velden J Papp Z Zaremba R | 2003 | Cardiovasc Res2003，57，1： | 1 |
| 17 | Reduced accumulation of specific microRNAs in colorectal neoplasia显示文摘 | Michael M Z O' Connor S M van Holst Pellekaan N G | 2003 | Mol Cancer Res2003，1，12： | 1 |
| 18 | Savoy: Absorption of methionine and 2-hydroxy-4-methylthiobutoanic acid in conventional and germ-free chickens显示文摘 | Drew M D Van Kessel A G Maer z D D | 2003 | Poultry Science2003，82，7： | 1 |
| 19 | Farfield impact of water injection dredging in the Crouch River 显示文摘 | Winterwerp J C Wang Z B Kester J A Th M van | 2002 | Water & maritime engineering2002，，4： | 1 |
| 20 | Reduced accumulation of specific microRNAs in colorectal neoplasia显示文摘 | Michael M Z O'Connor S M van Hoist Pellekaan N G | 2003 | Mol Cancer Res2003，1，： | 1 |
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