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| 1 | Gastroenterologist perceptions of faecal microbiota transplantation显示文摘AIM: To explore gastroenterologist perceptions towards and experience with faecal microbiota transplantation(FMT).METHODS: A questionnaire survey consisting of 17 questions was created to assess gastroenterologists' attitude towards and experience with FMT. This was anonymously distributed in hard copy format amongst attendees at gastroenterology meetings in Australia between October 2013 and April 2014. Basic descriptive statistical analyses were performed.RESULTS: Fifty-two clinicians participated. Twenty one percent had previously referred patients for FMT,8% more than once. Ninety percent would refer patients with Clostridium difficile infection(CDI) for FMT if easily available,37% for ulcerative colitis,13% for Crohn's disease and 6% for irritable bowel syndrome. Six percent would not refer any indication,including recurrent CDI. Eighty-six percent would enroll patients in FMT clinical trials. Thirty-seven percent considered the optimal mode of FMT administration transcolonoscopic,17% nasoduodenal,13% enema and 8% oral capsule. The greatest concerns regarding FMT were: 42% lack of evidence,12% infection risk,10% non infectious adverse effects/lack of safety data,10% aesthetic,10% lack of efficacy,4% disease exacerbation,and 2% inappropriate use; 6% had no concerns. Seventy seven percent believed there is a lack of accessibility while 52% had an interest in learning how to provide FMT. Only 6% offered FMT at their institution.CONCLUSION: Despite general enthusiasm,most gastroenterologists have limited experience with,or access to,FMT. The greatest concerns were lack of supportive evidence and safety issues. However a significant proportion would refer indications other than CDI for FMT despite insufficient evidence. These data provide guidance on where education and training are required. | Sudarshan Paramsothy Alissa J Walsh Thomas Borody Douglas Samuel Johan van den Bogaerde Rupert WL Leong Susan Connor Watson Ng Hazel M Mitchell Nadeem O Kaakoush Michael A Kamm | 2015 | World Journal of Gastroenterology2015，21，38： | 5 |
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| 15 | Markers of ap- optosis in cardiovascular tissues: focus on Annexin V 显示文摘 | van Heerde WL Robert-Offerman S Dumont E Hofstra L Doeven- dans PA Smits JF Daemen M J Reutelingsperger CP | 2000 | Cardiovasc Res2000，45，3： | 1 |
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| 17 | Glia proin- flammatory cytokine upregulation as a therapeutic target for neurode- generative diseases: function-based and target-based discovery ap- proaches 显示文摘 | Van Eldik LJ Thompson WL Ralay Ranaivo H | 2007 | Int Rev Neurobiol2007，82，： | 1 |
| 18 | Enhanced smooth muscle cell coverage of microvessels exposed to increased hemodynamic stresses in vivo显示文摘 | Van Gieson EJ Murfee WL Skalak TC | 2003 | Circ Res2003，92，8： | 1 |
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